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Tumor necrosis factor; Cachectin; TNF-alpha;.. [gi:135934] - Target BioActivity Data
Also known as: Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form.
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BioActivity Outcomes:
Active(33)
 
 
BioAssay Types:
Literature(17)
 
 
BioActivity Types:
Kd(11)
 
 
IC50(6)
 
 
Substance Types:
Chemical(33)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 33   Total Pages: 1   
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103452885]
[CID44395506]
IC50 0.0104Inhibitory concentration against TNF-alpha releasein LPS treated whole blood [AID247750, Type: Literature]
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2
[SID103272899]
[CID9886977]
IC50 0.048Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs [AID210150, Type: Literature]
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3
[SID103273474]
[CID9907830]
IC50 0.269Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs [AID210150, Type: Literature]
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4
[SID103272825]
[CID11783486]
IC50 0.928Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs [AID210150, Type: Literature]
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5
[SID103185380]
[CID119031]
IC50 1.001Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs [AID210150, Type: Literature]
View
6
[SID103273528]
[CID11824148]
IC50 1.606Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs [AID210150, Type: Literature]
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7
[SID103562257]
[CID5327044]
Kd 5.36Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solvent [AID733376, Type: other]
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8
[SID103562257]
[CID5327044]
Kd 5.36Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assay [AID733384, Type: other]
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9
[SID103562257]
[CID5327044]
Kd 5.7Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solvent [AID733383, Type: other]
View
10
[SID103562257]
[CID5327044]
Kd 5.75Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solvent [AID733381, Type: other]
View
11
[SID103562257]
[CID5327044]
Kd 6.18Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solvent [AID733374, Type: other]
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12
[SID103562257]
[CID5327044]
Kd 7.34Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solvent [AID733382, Type: other]
View
13
[SID103562257]
[CID5327044]
Kd 7.51Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solvent [AID733380, Type: other]
View
14
[SID103562257]
[CID5327044]
Kd 8.3Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solvent [AID733375, Type: other]
View
15
[SID103562257]
[CID5327044]
Kd 8.44Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solvent [AID733379, Type: other]
View
16
[SID103562257]
[CID5327044]
Kd 9.77Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solvent [AID732924, Type: other]
View
17
[SID103562257]
[CID5327044]
Kd 11.81Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solvent [AID732923, Type: other]
View
18
[SID103771203]
TNF-alpha inhibitor [AID742688, Type: other]
View
19
[SID103771314]
TNF-alpha inhibitor [AID742688, Type: other]
View
20
[SID103771449]
TNF-alpha inhibitor [AID742688, Type: other]
View
21
[SID103771529]
TNF-alpha inhibitor [AID742688, Type: other]
View
22
[SID103771531]
TNF-alpha inhibitor [AID742688, Type: other]
View
23
[SID164129805]
[CID71716471]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
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24
[SID164129806]
[CID71716472]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
25
[SID164132642]
[CID71717076]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
26
[SID164132643]
[CID71717077]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
27
[SID164132646]
[CID71717080]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
28
[SID164138300]
[CID71718304]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
29
[SID164138348]
[CID71718314]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
30
[SID164143904]
[CID71719520]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
31
[SID164143905]
[CID71719521]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
32
[SID164149572]
[CID71720770]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View
33
[SID164149574]
[CID71720772]
Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay [AID736485, Type: Literature]
View