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Metabotropic glutamate receptor 5; mGluR5 [gi:1170947] - Target BioActivity Data
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BioActivity Outcomes:
Active(892)
 
 
BioAssay Types:
Literature(890)
 
 
BioActivity Types:
IC50(362)
 
 
Ki(279)
 
 
EC50(243)
 
 
Kd(5)
 
 
Substance Types:
Chemical(892)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 84    Data Row: 892   Total Pages: 18   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103520919]
[CID16737207]
IC50 3.6e-05Displacement of [3H]MPEP from mGluR5 in rat brain membrane [AID291620, Type: Literature]
View
2
[SID103520919]
[CID16737207]
Ki 3.6e-05Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
3
[SID103520920]
[CID16737208]
IC50 6e-05Displacement of [3H]MPEP from mGluR5 in rat brain membrane [AID291620, Type: Literature]
View
4
[SID103614357]
[CID44574111]
Ki 8e-05Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
5
[SID131284870]
[CID53249063]
Ki 0.000106Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
6
[SID131276868]
[CID53249062]
Ki 0.000127Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
7
[SID131280906]
[CID46208249]
Ki 0.0002Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
8
[SID103256385]
[CID3025961]
IC50 0.0002Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay [AID299817, Type: Literature]
View
9
[SID103520925]
[CID16736578]
IC50 0.00023Displacement of [3H]MPEP from mGluR5 in rat brain membrane [AID291620, Type: Literature]
View
10
[SID103478374]
[CID11535913]
Ki 0.00025Displacement of [3H]MPEP from mGluR5 in rat brain membranes [AID259885, Type: Literature]
View
11
[SID124968322]
[CID51050145]
Ki 0.00025Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
12
[SID124960417]
[CID51039242]
Ki 0.00027Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
13
[SID124968324]
[CID51050257]
Ki 0.00028Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
14
[SID131286927]
[CID53249064]
Ki 0.0003Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
15
[SID131278895]
[CID53249061]
IC50 0.00032Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
16
[SID131280842]
[CID54584297]
Ki 0.00036Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
17
[SID103614357]
[CID44574111]
Ki 0.00036Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
18
[SID131278896]
[CID54583366]
IC50 0.00039Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
19
[SID124971325]
[CID51039243]
Ki 0.0004Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
20
[SID103447884]
[CID11378977]
IC50 0.000415Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate challenge by calcium fluorescence assay [AID375051, Type: Literature]
View
21
[SID103520921]
[CID16736577]
IC50 0.00048Displacement of [3H]MPEP from mGluR5 in rat brain membrane [AID291620, Type: Literature]
View
22
[SID103520923]
[CID16737209]
IC50 0.00052Displacement of [3H]MPEP from mGluR5 in rat brain membrane [AID291620, Type: Literature]
View
23
[SID103750886]
[CID46237677]
Kd 0.0006Binding affinity to mGluR5 ligand binding site 1 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma counting [AID479139, Type: Literature]
View
24
[SID131286927]
[CID53249064]
IC50 0.00061Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
25
[SID131282902]
[CID54585280]
IC50 0.00063Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
26
[SID131280907]
[CID54584312]
IC50 0.00066Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
27
[SID131280906]
[CID46208249]
IC50 0.00066Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
28
[SID131284869]
[CID54586229]
IC50 0.00066Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
29
[SID131284872]
[CID46208250]
Ki 0.00067Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting [AID683163, Type: Literature]
View
30
[SID131282901]
[CID54585279]
Ki 0.00069Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
31
[SID131276871]
[CID54582380]
IC50 0.00071Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
32
[SID103477959]
[CID11608287]
Ki 0.00071Displacement of [3H]MPEP from mGluR5 in rat brain membranes [AID259885, Type: Literature]
View
33
[SID103539389]
[CID44435034]
IC50 0.00072Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology [AID301047, Type: Literature]
View
34
[SID131286855]
[CID54587232]
IC50 0.00073Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
35
[SID103535798]
[CID23661671]
IC50 0.0008Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay [AID299817, Type: Literature]
View
36
[SID103614357]
[CID44574111]
IC50 0.000813Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate challenge by calcium fluorescence assay [AID375051, Type: Literature]
View
37
[SID124966087]
[CID51050144]
Ki 0.0009Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
38
[SID131286855]
[CID54587232]
Ki 0.00093Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
39
[SID124960418]
[CID51050150]
Ki 0.00095Displacement of [3H]MPEP from mGluR5 in rat brain [AID570310, Type: Literature]
View
40
[SID131276872]
[CID54582381]
IC50 0.00102Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
41
[SID131282904]
[CID54585282]
IC50 0.00103Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
42
[SID103447884]
[CID11378977]
Ki 0.00104Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting [AID683163, Type: Literature]
View
43
[SID131284871]
[CID54586230]
IC50 0.00105Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
44
[SID131284870]
[CID53249063]
IC50 0.00106Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
45
[SID131282900]
[CID44157258]
Ki 0.00106Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting [AID601416, Type: Literature]
View
46
[SID131282900]
[CID44157258]
IC50 0.00111Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
47
[SID103539388]
[CID24180510]
IC50 0.0012Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology [AID301047, Type: Literature]
View
48
[SID103448906]
[CID44392990]
IC50 0.00121Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate challenge by calcium fluorescence assay [AID375051, Type: Literature]
View
49
[SID131282903]
[CID54585281]
IC50 0.00122Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View
50
[SID131276870]
[CID54582379]
IC50 0.00122Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization [AID601415, Type: Literature]
View