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Amyloid beta A4 protein; ABPP; APPI; APP; Alz.. [gi:112927] - Target BioActivity Data
Also known as: Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); C31.
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BioActivity Outcomes:
Active(220)
 
 
BioAssay Types:
Literature(218)
 
 
Confirmatory(2)
 
 
BioActivity Types:
IC50(107)
 
 
Ki(69)
 
 
EC50(33)
 
 
Potency(2)
 
 
Substance Types:
Chemical(220)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 38    Data Row: 220   Total Pages: 5   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103500757]
[CID16087306]
Ki 7e-05Displacement of [125I]IMSB from beta amyloid protein 40 [AID272869, Type: Literature]
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2
[SID103244775]
[CID6913223]
Ki 0.00014Inhibition constant for aggregates of amyloid beta compared to [125I]IMSB [AID38550, Type: Literature]
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3
[SID103244775]
[CID6913223]
Ki 0.00016Displacement of [125I]IMSB from beta amyloid protein 40 [AID272869, Type: Literature]
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4
[SID103244757]
[CID10745352]
Ki 0.00017Inhibition constant for aggregates of amyloid beta compared to [125I]IMSB [AID38550, Type: Literature]
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5
[SID103340697]
[CID5281767]
Ki 0.000208Displacement of [125I]IMSB from beta amyloid protein 40 [AID272869, Type: Literature]
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6
[SID103540126]
[CID11354073]
IC50 0.0003Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
7
[SID103486262]
[CID11550464]
Ki 0.0007Displacement of [125I]IMPY from beta amyloid in human corpse AD brain [AID264125, Type: Literature]
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8
[SID103244759]
[CID10547782]
Ki 0.0009Inhibition constant for amyloid beta compared to [125I]TZDM [AID38549, Type: Literature]
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9
[SID103470080]
[CID10013901]
Ki 0.0012Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
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10
[SID103486261]
[CID11708629]
Ki 0.0013Displacement of [125I]IMPY from beta amyloid in human corpse AD brain [AID264125, Type: Literature]
View
11
[SID103244758]
[CID10762840]
Ki 0.0016Inhibition constant for amyloid beta compared to [125I]TZDM [AID38549, Type: Literature]
View
12
[SID103244760]
[CID10496851]
Ki 0.0019Inhibition constant for amyloid beta compared to [125I]TZDM [AID38549, Type: Literature]
View
13
[SID103486329]
[CID11579589]
Ki 0.0023Displacement of [125I]IMPY from beta amyloid in human corpse AD brain [AID264125, Type: Literature]
View
14
[SID103540105]
[CID11851431]
IC50 0.0024Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
15
[SID103540128]
[CID44435363]
IC50 0.0025Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
16
[SID103540127]
[CID44435362]
IC50 0.0028Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
17
[SID103486264]
[CID11543378]
Ki 0.0028Displacement of [125I]IMPY from beta amyloid in human corpse AD brain [AID264125, Type: Literature]
View
18
[SID103303707]
[CID10171487]
Ki 0.0028Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
View
19
[SID103540153]
[CID44435378]
IC50 0.0032Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
20
[SID103540129]
[CID44435364]
IC50 0.0035Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
21
[SID103540130]
[CID44435365]
IC50 0.0035Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
22
[SID103540160]
[CID44435384]
IC50 0.0035Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
23
[SID103482452]
[CID11623805]
Ki 0.0039Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
24
[SID103481966]
[CID14905189]
Ki 0.004Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
25
[SID103303707]
[CID10171487]
Ki 0.0043Binding affinity to beta amyloid in human corpse AD brain [AID264144, Type: Literature]
View
26
[SID103540153]
[CID44435378]
IC50 0.0043Inhibition of gamma-secretase assessed as reduction of cell A-beta-40 level [AID301169, Type: Literature]
View
27
[SID103282436]
[CID10133297]
Ki 0.005Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
View
28
[SID103244757]
[CID10745352]
Ki 0.0051Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uL [AID264494, Type: Literature]
View
29
[SID103477977]
[CID11621627]
IC50 0.0052Inhibition of soluble APPbeta N-terminal fragment secretion in cultured HEK293T cells [AID259620, Type: Literature]
View
30
[SID103244773]
[CID10844298]
Ki 0.0054Inhibition constant for amyloid beta compared to [125I]TZDM [AID38549, Type: Literature]
View
31
[SID103482239]
[CID44408839]
Ki 0.0056Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
32
[SID103470080]
[CID10013901]
Ki 0.006Binding affinity to beta amyloid in human corpse AD brain [AID264144, Type: Literature]
View
33
[SID103481967]
[CID44408738]
Ki 0.0061Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
34
[SID103481968]
[CID21788024]
Ki 0.0061Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
35
[SID103540159]
[CID24180452]
IC50 0.0069Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
36
[SID103540166]
[CID44435390]
IC50 0.0069Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
37
[SID103482250]
[CID44408847]
Ki 0.0075Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
38
[SID103487348]
[CID11608986]
Ki 0.0075Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
View
39
[SID103540160]
[CID44435384]
IC50 0.0077Inhibition of gamma-secretase assessed as reduction of cell A-beta-40 level [AID301169, Type: Literature]
View
40
[SID103488750]
[CID44411898]
Ki 0.0078Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue [AID265144, Type: Literature]
View
41
[SID103540159]
[CID24180452]
IC50 0.0083Inhibition of gamma-secretase assessed as reduction of cell A-beta-40 level [AID301169, Type: Literature]
View
42
[SID103540155]
[CID44435380]
IC50 0.009Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
43
[SID103487339]
[CID11587026]
Ki 0.009Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
View
44
[SID103487347]
[CID11507217]
Ki 0.009Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL [AID264495, Type: Literature]
View
45
[SID103500747]
[CID16087293]
Ki 0.00937Displacement of [125I]IMSB from beta amyloid protein 40 [AID272869, Type: Literature]
View
46
[SID103540164]
[CID44435388]
IC50 0.0096Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
47
[SID103482240]
[CID44408840]
Ki 0.0096Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates [AID261997, Type: Literature]
View
48
[SID103540156]
[CID44435381]
IC50 0.01Inhibition of gamma-secretase assessed as reduction of cell A-beta-40 level [AID301169, Type: Literature]
View
49
[SID103540161]
[CID44435385]
IC50 0.01Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 level [AID301167, Type: Literature]
View
50
[SID103282436]
[CID10133297]
Ki 0.0103Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue [AID265144, Type: Literature]
View