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GRIN2B (geneid:2904) - Gene BioActivity Data
Also known as: GluN2B, MRD6, NMDAR2B, NR2B, hNR3.
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BioActivity Outcomes:
Active(202)
 
 
BioAssay Types:
Literature(195)
 
 
BioActivity Types:
Ki(93)
 
 
IC50(84)
 
 
Substance Types:
Chemical(202)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 23    Data Row: 202   Total Pages: 5   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103257627]
[CID10472142]
Ki 0.0004Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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2
[SID103257697]
[CID9865365]
Ki 0.00068Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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3
[SID103257661]
[CID10316274]
Ki 0.00082Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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4
[SID103258347]
[CID9840849]
Ki 0.00085Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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5
[SID103508892]
[CID9822219]
Ki 0.00099Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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6
[SID103258378]
[CID10337265]
Ki 0.0011Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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7
[SID103508892]
[CID9822219]
IC50 0.0014Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influx [AID606299, Type: Literature] [gi:14548162]
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8
[SID103257717]
[CID9883600]
Ki 0.0015Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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9
[SID103257717]
[CID9883600]
Ki 0.0015Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR1a/NR2b receptor expressed in mouse Ltk cells [AID526572, Type: Literature] [gi:14548162]
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10
[SID103550215]
[CID9927645]
Ki 0.002Binding affinity to NMDA NR2B receptor [AID307754, Type: Literature] [gi:14548162]
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11
[SID103550216]
[CID44441274]
Ki 0.0022Binding affinity to NMDA NR2B receptor [AID307754, Type: Literature] [gi:14548162]
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12
[SID103258521]
[CID9849584]
Ki 0.003Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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13
[SID103257657]
[CID9839919]
Ki 0.0032Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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14
[SID123091396]
[CID49832961]
Ki 0.0033Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
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15
[SID103506464]
[CID9881090]
Ki 0.0034Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
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16
[SID103550225]
[CID9862575]
Ki 0.0036Binding affinity to NMDA NR2B receptor [AID307754, Type: Literature] [gi:14548162]
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17
[SID103506465]
[CID16109419]
Ki 0.0037Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
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18
[SID103258346]
[CID10042818]
Ki 0.0042Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
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19
[SID123085516]
[CID46845430]
Ki 0.0054Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
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20
[SID103550225]
[CID9862575]
IC50 0.0059Antagonist activity at NMDA NR2B receptor assessed as calcium flux [AID307755, Type: Literature] [gi:14548162]
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21
[SID103506472]
[CID16109395]
Ki 0.0078Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
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22
[SID160677645]
[CID70685326]
IC50 0.00794Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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23
[SID160682960]
[CID1394668]
IC50 0.00794Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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24
[SID160693777]
[CID70691639]
IC50 0.00794Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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25
[SID103550206]
[CID22616316]
Ki 0.008Binding affinity to NMDA NR2B receptor [AID307754, Type: Literature] [gi:14548162]
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26
[SID123093750]
[CID49832961]
Ki 0.009Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
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27
[SID124960908]
[CID3689]
Ki 0.01Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
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28
[SID103506559]
[CID9797385]
Ki 0.0106Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
29
[SID103258378]
[CID10337265]
IC50 0.012Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influx [AID606299, Type: Literature] [gi:14548162]
View
30
[SID103550216]
[CID44441274]
IC50 0.012Antagonist activity at NMDA NR2B receptor assessed as calcium flux [AID307755, Type: Literature] [gi:14548162]
View
31
[SID160704503]
[CID70695844]
IC50 0.01259Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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32
[SID103201763]
[CID60703]
Ki 0.013Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
View
33
[SID103506570]
[CID9967123]
Ki 0.014Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
34
[SID123099027]
[CID49832807]
Ki 0.014Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
View
35
[SID103257811]
[CID11247204]
Ki 0.015Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
View
36
[SID103257806]
[CID9825245]
Ki 0.017Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
View
37
[SID103506587]
[CID16109391]
Ki 0.018Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
38
[SID103506593]
[CID10269028]
Ki 0.018Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
39
[SID123099027]
[CID49832807]
IC50 0.0185Antagonist activity at human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells assessed as inhibition of (S)-glutamate/glycine-stimulated excitotoxicity treated 30 mins before (S)-glutamate/glycine challenge measured after 4 hrs by LDH release assay [AID538753, Type: Literature] [gi:14548162]
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40
[SID123099028]
[CID49832956]
Ki 0.02Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
View
41
[SID103257812]
[CID9828572]
Ki 0.021Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells [AID146213, Type: Literature] [gi:14548162]
View
42
[SID103506571]
[CID9923385]
Ki 0.023Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
43
[SID103506586]
[CID16109390]
Ki 0.023Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
44
[SID160699153]
[CID70693725]
IC50 0.03162Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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45
[SID123093751]
[CID49832957]
Ki 0.036Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
View
46
[SID123084639]
[CID49832812]
Ki 0.037Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting [AID538755, Type: Literature] [gi:14548162]
View
47
[SID103506560]
[CID10268204]
Ki 0.037Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR2B expressed in Ltk- cells [AID277227, Type: Literature] [gi:14548162]
View
48
[SID103550215]
[CID9927645]
IC50 0.039Antagonist activity at NMDA NR2B receptor assessed as calcium flux [AID307755, Type: Literature] [gi:14548162]
View
49
[SID160693778]
[CID70691640]
IC50 0.03981Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
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50
[SID160704504]
[CID70695845]
IC50 0.03981Displacement of [3H]-Ro256981 from human NR2B receptor [AID654953, Type: Literature] [gi:14548162]
View