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Prostaglandin G/H synthase 1; Cyclooxygenase-.. [gi:317373262] - Target BioActivity Data
Also known as: Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1.
BioActivity Outcomes:
Active(768)
 
 
Inactive(90)
 
 
Inconclusive(45)
 
 
Unspecified(1833)
 
 
BioAssay Types:
Literature(1719)
 
 
 
 
 
Confirmatory(916)
 
 
 
 
 
BioActivity Types:
IC50(1839)
 
 
 
 
 
Kd(6)
 
 
Ki(5)
 
 
 
Substance Types:
Chemical(2736)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 226    Data Row: 2736   Total Pages: 137   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID136936278]
[CID44541795]
IC50 0.00123Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured after 15 mins by ELISA [AID642830, Type: Literature]
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2
[SID104248262]
[CID46926545]
IC50 0.002Inhibition of human COX1 [AID547805, Type: Literature]
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3
[SID103278341]
[CID5018304]
IC50 0.003Inhibition of COX-1 (unknown origin) [AID1083357, Type: confirmatory]
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4
[SID103272743]
[CID667550]
IC50 0.00448DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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5
[SID103163840]
[CID3715]
IC50 0.005Inhibition of COX1 assessed as TBX2 production in human whole blood [AID271283, Type: Literature]
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6
[SID103293849]
[CID60726]
IC50 0.00848DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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7
[SID103199497]
[CID4306515]
IC50 0.0089Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassay [AID738676, Type: Literature]
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8
[SID103181246]
[CID44271350]
IC50 0.01Inhibition of human Prostaglandin G/H synthase 1 [AID161333, Type: Literature]
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9
[SID103191369]
[CID3033]
IC50 0.012Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2 [AID312490, Type: Literature]
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10
[SID103168363]
[CID3826]
IC50 0.013DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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11
[SID103191369]
[CID3033]
IC50 0.013DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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12
[SID134452956]
[CID56642537]
IC50 0.014Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysis [AID620322, Type: Literature]
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13
[SID103179087]
[CID3825]
IC50 0.014DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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14
[SID103163840]
[CID3715]
IC50 0.015DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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15
[SID103191369]
[CID3033]
IC50 0.015Inhibition of human cyclooxygenase 1 [AID340309, Type: Literature]
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16
[SID194183088]
[CID71388947]
Kd 0.0156Binding affinity to COX1 (unknown origin) [AID1086517, Type: confirmatory]
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17
[SID103163840]
[CID3715]
IC50 0.02Inhibition of COX1 (unknown origin)-mediated oxidation of N,N,N,Ntetramethyl-1,4-phenylenediamine using arachidonic acid as substrate by colorimetric assay [AID729252, Type: Literature]
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18
[SID103178857]
[CID3394]
IC50 0.021DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]
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19
[SID103163840]
[CID3715]
IC50 0.0282Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISA [AID396714, Type: Literature]
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20
[SID103191369]
[CID3033]
IC50 0.03Inhibition of human COX1 expressed in sf9 cells [AID403703, Type: Literature]
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