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metallo-beta-lactamase IMP-1 [Pseudomonas aer.. [gi:27368096] - Target BioActivity Data
Also known as: metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa].
BioActivity Outcomes:
Probe(3)
 
 
Active(1473)
 
 
Inactive(291260)
 
 
BioAssay Types:
Screening(292355)
 
 
 
Confirmatory(348)
 
 
 
 
BioActivity Types:
IC50(347)
 
 
 
 
Ki(1)
 
 
Substance Types:
Chemical(292736)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 292736   Total Pages: 14637   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID125264855]
[CID53362017]
MIC [4 fold reduction] 0.781Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
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2
[SID134220672]
[CID53362017]
Ki 0.93Late stage assay provider results from the probe development efforts to identify nonselective inhibitors of VIM-2 metallo-beta-lactamase: Absorbance-based biochemical assays to determine the ability of probe candidates and selected analogs to inhibit IMP-1 [AID624084, Type: confirmatory]
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3
[SID125264855]
[CID53362017]
IC50 3.018Late stage assay provider results from the probe development efforts to identify nonselective inhibitors of VIM-2 metallo-beta-lactamase: Absorbance-based biochemical assays to determine the ability of probe candidates and selected analogs to inhibit IMP-1 [AID624085, Type: confirmatory]
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4
[SID49679995]
[CID2818392]
IC50 0.39877Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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5
[SID131269027]
[CID54579797]
MIC [4 fold reduction] 0.781Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
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6
[SID126723253]
[CID53495082]
MIC [4 fold reduction] 0.781Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
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7
[SID26659839]
[CID776411]
IC50 1.024Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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8
[SID92192482]
[CID45105306]
IC50 1.327Late stage results from the probe development effort to identify common IMP-1 and VIM-2 inhibitors: Epi-absorbance-based biochemical dose response assay for inhibitors of IMP-1metallo-beta-lactamase [AID2768, Type: confirmatory]
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9
[SID92192480]
[CID10448266]
IC50 1.507Late stage results from the probe development effort to identify common IMP-1 and VIM-2 inhibitors: Epi-absorbance-based biochemical dose response assay for inhibitors of IMP-1metallo-beta-lactamase [AID2768, Type: confirmatory]
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10
[SID125311278]
[CID53384679]
MIC [4 fold reduction] 1.563Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
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11
[SID848038]
[CID650462]
IC50 1.622Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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12
[SID92192478]
[CID45105304]
IC50 1.806Late stage results from the probe development effort to identify common IMP-1 and VIM-2 inhibitors: Epi-absorbance-based biochemical dose response assay for inhibitors of IMP-1metallo-beta-lactamase [AID2768, Type: confirmatory]
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13
[SID7971429]
[CID1789058]
IC50 2.115Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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14
[SID92192479]
[CID45105307]
IC50 2.33Late stage results from the probe development effort to identify common IMP-1 and VIM-2 inhibitors: Epi-absorbance-based biochemical dose response assay for inhibitors of IMP-1metallo-beta-lactamase [AID2768, Type: confirmatory]
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15
[SID22409753]
[CID3517787]
IC50 2.51Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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16
[SID22405113]
[CID3614365]
IC50 2.777Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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17
[SID126723255]
[CID53495083]
MIC [4 fold reduction] 3.125Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
View
18
[SID124767346]
[CID53308605]
MIC [4 fold reduction] 3.125Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective):IMP-1-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624097, Type: other]
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19
[SID7977150]
[CID94381]
IC50 3.241Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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20
[SID22405114]
[CID5199378]
IC50 3.319Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]
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