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BioActivity Data for Gene VDR (Gene ID:7421)

Also known as: NR1I1, PPP1R163.
BioActivity Outcomes:
Active(6047)
 
 
Inactive(420270)
 
 
Inconclusive(21894)
 
 
Unspecified(544)
 
 
BioAssay Types:
Confirmatory(428843)
 
 
 
 
Summary(18610)
 
 
 
 
Literature(1226)
 
 
 
 
 
Screening(47)
 
 
 
BioAssay Categories:
Biochemical(690)
 
 
 
 
 
Cell-based(759)
 
 
 
 
 
Toxicity(3)
 
 
ADME(28)
 
 
 
In vitro(112)
 
 
 
 
 
BioActivity Types:
Potency(438148)
 
 
 
 
IC50(364)
 
 
 
 
 
EC50(147)
 
 
 
 
 
Ki(12)
 
 
Kd(3)
 
 
Substance Types:
Chemical(448740)
 
 
 
 
 
RNAi(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 219    Data Row: 448755   Total Pages: 22438   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103508828]
[CID44420575]
EC50 2e-06Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assay [AID280115, Type: Literature] [gi:137617]
View
2
[SID103508814]
[CID44420574]
EC50 3e-06Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assay [AID280115, Type: Literature] [gi:137617]
View
3
[SID103221863]
[CID5280453]
EC50 1e-05Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activation measured 24 hrs post infection by luciferase reporter gene assay [AID622098, Type: Literature] [gi:137617]
View
4
[SID174512904]
[CID71764798]
EC50 1e-05Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay [AID760217, Type: Literature] [gi:137617]
View
5
[SID103221863]
[CID5280453]
EC50 1.06e-05Effect on VDR transcriptional activity in human osteosarcoma cells [AID321740, Type: Literature] [gi:137617]
View
6
[SID103221863]
[CID5280453]
EC50 2.6e-05Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay [AID760217, Type: Literature] [gi:137617]
View
7
[SID160701469]
[CID57522254]
IC50 2.9e-05Displacement of [3H]1alpha,25-dihydroxyvitamin D3 from human recombinant GST-tagged vitamin D3 receptor LBD expressed in Escherichia coli BL21 after 16 hrs [AID673011, Type: Literature] [gi:137617]
View
8
[SID103702411]
[CID45484851]
ED50 3e-05Agonist activity at human VDR expressed in human HOS cells co-transfected with RXR gene assessed as osteocalcin promoter gene transactivation after 24 hrs by luciferase assay [AID447020, Type: Literature] [gi:137617]
View
9
[SID103575226]
[CID24936209]
EC50 3.96e-05Effect on VDR transcriptional activity in human osteosarcoma cells [AID321740, Type: Literature] [gi:137617]
View
10
[SID103575226]
[CID24936209]
EC50 4e-05Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activation measured 24 hrs post infection by luciferase reporter gene assay [AID622098, Type: Literature] [gi:137617]
View
11
[SID174497335]
[CID71764801]
EC50 4.4e-05Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay [AID760217, Type: Literature] [gi:137617]
View
12
[SID134451656]
[CID56603803]
EC50 6e-05Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activation measured 24 hrs post infection by luciferase reporter gene assay [AID622098, Type: Literature] [gi:137617]
View
13
[SID103517327]
[CID44423319]
EC50 7e-05Inhibition of human VDR induced-transcriptional transactivation of luciferase reporter gene in COS7 cells after 24 hrs [AID287170, Type: Literature] [gi:137617]
View
14
[SID242637109]
[CID71484079]
EC50 7e-05Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by luciferase reporter assay [AID1142108, Type: Literature] [gi:137617]
View
15
[SID103221863]
[CID5280453]
IC50 8e-05Displacement of [3H]-1-alpha,25-dihydroxyvitamin D3 from N-terminal GST-tagged human recombinant VDR LBD expressed in Escherichia coli Rosetta2 (DE3) after 16 hrs [AID1140744, Type: Literature] [gi:137617]
View
16
[SID174524899]
[CID73357083]
EC50 0.0001Agonist activity at VDR ligand binding domain (unknown origin) by reporter gene assay [AID775185, Type: Literature] [gi:137617]
View
17
[SID242637403]
[CID90656370]
IC50 0.00012Displacement of [3H]-1-alpha,25-dihydroxyvitamin D3 from N-terminal GST-tagged human recombinant VDR LBD expressed in Escherichia coli Rosetta2 (DE3) after 16 hrs [AID1140744, Type: Literature] [gi:137617]
View
18
[SID103702429]
[CID44555479]
ED50 0.00012Agonist activity at human VDR expressed in human HOS cells co-transfected with RXR gene assessed as osteocalcin promoter gene transactivation after 24 hrs by luciferase assay [AID447020, Type: Literature] [gi:137617]
View
19
[SID174492258]
[CID71764800]
EC50 0.00015Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assay [AID760217, Type: Literature] [gi:137617]
View
20
[SID103508829]
[CID44420576]
EC50 0.0002Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assay [AID280115, Type: Literature] [gi:137617]
View