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TRPM2 (geneid:7226) - Gene BioActivity Data
Also known as: EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7.
BioActivity Outcomes:
Active(8)
 
 
Inactive(28)
 
 
Unspecified(12)
 
 
BioAssay Types:
Literature(36)
 
 
 
 
Screening(10)
 
 
BioActivity Types:
IC50(12)
 
 
 
EC50(1)
 
 
Substance Types:
Chemical(37)
 
 
 
 
RNAi(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 21    Data Row: 48   Total Pages: 3   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103424618]
[CID1598]
IC50 1Inhibition of human TRPM2 expressed in HEK293 cells [AID1065919, Type: Literature] [gi:160381681]
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2
[SID103430866]
[CID5353376]
IC50 1.7Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of H2O2-induced intracellular calcium level by patch clamp technique [AID1065920, Type: Literature] [gi:160381681]
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3
[SID103244070]
IC50 2.6Inhibition of TRPM2 (unknown origin) expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp technique [AID1065918, Type: Literature] [gi:160381681]
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4
[SID103176241]
[CID2812]
IC50 3Inhibition of TRPM2 (unknown origin) [AID1065914, Type: Literature] [gi:160381681]
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5
[SID103212333]
[CID3198]
IC50 3Inhibition of TRPM2 (unknown origin) [AID1065914, Type: Literature] [gi:160381681]
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6
[SID194139495]
[CID76310334]
Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at 100 uM at +15 mV by whole-cell patch-clamp electrophysiology [AID1065916, Type: Literature] [gi:160381681]
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7
[SID194146366]
[CID76314003]
Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in fMLP-induced chemotaxis at 100 uM preincubated for 15 mins followed by fMLP-challenge by microscopic analysis [AID1065910, Type: Literature] [gi:160381681]
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8
[SID194160206]
[CID76321280]
Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at 900 uM at +15 mV by whole-cell patch-clamp electrophysiology [AID1065915, Type: Literature] [gi:160381681]
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9
[SID103201463]
[CID6083]
IC50 70Inhibition of TRPM2 (unknown origin) [AID1065914, Type: Literature] [gi:160381681]
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10
[SID103191339]
[CID3371]
IC50 70Inhibition of human recombinant TRPM2 [AID1065922, Type: Literature] [gi:160381681]
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11
[SID103191721]
[CID85472]
IC50 76Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp electrophysiology [AID1065921, Type: Literature] [gi:160381681]
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12
[SID103476697]
[CID636430]
IC50 100Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by whole-cell patch-clamp electrophysiology [AID1065917, Type: Literature] [gi:160381681]
View
13
[SID194151507]
[CID33576]
EC50 100Activation of TRPM2 (unknown origin) [AID1065923, Type: Literature] [gi:160381681]
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14
[SID103191448]
[CID4044]
IC50 124Inhibition of human recombinant TRPM2 [AID1065922, Type: Literature] [gi:160381681]
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15
[SID103253261]
[CID4488]
IC50 149Inhibition of human recombinant TRPM2 [AID1065922, Type: Literature] [gi:160381681]
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16
[SID194173961]
[CID76328457]
IC50 900Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as partial inhibition of ADPR-induced maximum outward potassium current at +15 mV by whole-cell patch-clamp electrophysiology [AID1065913, Type: Literature] [gi:160381681]
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17
[SID194146366]
[CID76314003]
Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in A5 peptide-induced intracellular calcium accumulation at 100 uM preincubated for 15 mins followed by A5 peptide-challenge by fluorescence microscopic analysis relative to control [AID1065911, Type: Literature] [gi:160381681]
View
18
[SID194146366]
[CID76314003]
Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in fMLP-induced intracellular calcium accumulation at 100 uM preincubated for 15 mins followed by fMLP-challenge by fluorescence microscopic analysis relative to control [AID1065912, Type: Literature] [gi:160381681]
View
19
[SID85101237]
siRNA Circadian Assay [AID1904, Type: other] [geneid:7226]
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20
[SID85108460]
siRNA Circadian Assay [AID1904, Type: other] [geneid:7226]
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