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PTGS1 (geneid:5742) - Gene BioActivity Data
Also known as: RP11-542K23.6, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS.
BioActivity Outcomes:
Active(588)
 
 
Inactive(53)
 
 
Inconclusive(41)
 
 
Unspecified(1730)
 
 
BioAssay Types:
Literature(1426)
 
 
 
 
 
BioActivity Types:
IC50(1765)
 
 
 
 
 
Ki(2)
 
 
Substance Types:
Chemical(2405)
 
 
 
 
 
RNAi(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 173    Data Row: 2412   Total Pages: 49   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136936278]
[CID44541795]
IC50 0.00123Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured after 15 mins by ELISA [AID642830, Type: Literature] [gi:317373262]
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2
[SID104248262]
[CID46926545]
IC50 0.002Inhibition of human COX1 [AID547805, Type: Literature] [gi:317373262]
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3
[SID103272743]
[CID667550]
IC50 0.00448DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
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4
[SID103163840]
[CID3715]
IC50 0.005Inhibition of COX1 assessed as TBX2 production in human whole blood [AID271283, Type: Literature] [gi:317373262]
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5
[SID103293849]
[CID60726]
IC50 0.00848DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
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6
[SID103199497]
[CID4306515]
IC50 0.0089Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassay [AID738676, Type: Literature] [gi:317373262]
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7
[SID103181246]
[CID44271350]
IC50 0.01Inhibition of human Prostaglandin G/H synthase 1 [AID161333, Type: Literature] [gi:317373262]
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8
[SID103191369]
[CID3033]
IC50 0.012Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2 [AID312490, Type: Literature] [gi:317373262]
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9
[SID103168363]
[CID3826]
IC50 0.013DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
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10
[SID103191369]
[CID3033]
IC50 0.013DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
11
[SID134452956]
[CID56642537]
IC50 0.014Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysis [AID620322, Type: Literature] [gi:317373262]
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12
[SID103179087]
[CID3825]
IC50 0.014DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
13
[SID103163840]
[CID3715]
IC50 0.015DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
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14
[SID103191369]
[CID3033]
IC50 0.015Inhibition of human cyclooxygenase 1 [AID340309, Type: Literature] [gi:317373262]
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15
[SID103163840]
[CID3715]
IC50 0.02Inhibition of COX1 (unknown origin)-mediated oxidation of N,N,N,Ntetramethyl-1,4-phenylenediamine using arachidonic acid as substrate by colorimetric assay [AID729252, Type: Literature] [gi:317373262]
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16
[SID103178857]
[CID3394]
IC50 0.021DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
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17
[SID103163840]
[CID3715]
IC50 0.0282Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISA [AID396714, Type: Literature] [gi:317373262]
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18
[SID103191369]
[CID3033]
IC50 0.03Inhibition of human COX1 expressed in sf9 cells [AID403703, Type: Literature] [gi:317373262]
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19
[SID103436777]
[CID9822795]
IC50 0.03Inhibitory concentration against prostaglandin G/H synthase [AID254735, Type: Literature] [gi:317373262]
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20
[SID103163840]
[CID3715]
IC50 0.0338Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by EIA [AID612633, Type: Literature] [gi:317373262]
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21
[SID103163840]
[CID3715]
IC50 0.036Inhibition of human platelet COX1 by EIA assay [AID286231, Type: Literature] [gi:317373262]
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22
[SID103163840]
[CID3715]
IC50 0.039Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1 [AID161343, Type: other] [gi:317373262]
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23
[SID103495548]
[CID10237369]
IC50 0.04Inhibition of COX1-mediated platelet aggregation [AID268670, Type: Literature] [gi:317373262]
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24
[SID134453120]
[CID56642290]
IC50 0.041Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysis [AID620322, Type: Literature] [gi:317373262]
View
25
[SID103273527]
[CID5509]
IC50 0.041DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
26
[SID134453758]
[CID53379501]
IC50 0.0424Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by EIA [AID612633, Type: Literature] [gi:317373262]
View
27
[SID103163840]
[CID3715]
IC50 0.044Inhibition of human platelet COX1 using arachidonic acid as substrate preincubated for 15 mins before arachidonic acid addition measured after 15 mins [AID702430, Type: Literature] [gi:317373262]
View
28
[SID103455284]
[CID10377376]
IC50 0.05In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assay [AID242102, Type: Literature] [gi:317373262]
View
29
[SID160671983]
[CID54683953]
IC50 0.055DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
30
[SID103749862]
[CID54704052]
IC50 0.055DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
31
[SID103223949]
[CID3177]
IC50 0.059Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1 [AID161343, Type: other] [gi:317373262]
View
32
[SID103175945]
[CID15153337]
IC50 0.06Inhibition of Prostaglandin G/H synthase 1 (COX-1). [AID161680, Type: Literature] [gi:317373262]
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33
[SID136935722]
[CID18542237]
IC50 0.0659Inhibition of COX-1-mediated TXB2 production in human platelets preincubated for 20 mins prior A23187 stimulation measured after 15 mins by RIA [AID648038, Type: Literature] [gi:317373262]
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34
[SID103163840]
[CID3715]
IC50 0.07Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysis [AID620322, Type: Literature] [gi:317373262]
View
35
[SID103181197]
[CID22911977]
IC50 0.08Inhibition of human Prostaglandin G/H synthase 1 [AID161333, Type: Literature] [gi:317373262]
View
36
[SID104236512]
[CID44475686]
IC50 0.08Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay [AID471116, Type: Literature] [gi:317373262]
View
37
[SID103454969]
[CID9991673]
IC50 0.09In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assay [AID242102, Type: Literature] [gi:317373262]
View
38
[SID103176066]
[CID10516483]
IC50 0.095Inhibition of Prostaglandin G/H synthase 1 (COX-1). [AID161680, Type: Literature] [gi:317373262]
View
39
[SID103459707]
[CID39912]
IC50 0.09865Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured after 15 mins by ELISA [AID642830, Type: Literature] [gi:317373262]
View
40
[SID103742445]
[CID44475842]
IC50 0.1Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay [AID471116, Type: Literature] [gi:317373262]
View
41
[SID103191746]
[CID10642557]
IC50 0.1In vitro potency against human Prostaglandin G/H synthase 1 (hCOX-1) in the human whole blood assay. [AID161336, Type: Literature] [gi:317373262]
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42
[SID103459707]
[CID39912]
IC50 0.105DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
43
[SID103191448]
[CID4044]
IC50 0.116DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other] [gi:317373262]
View
44
[SID103644017]
[CID11688434]
IC50 0.116Inhibition of COX-1 in human OVCAR3 cells using [14C] arachidonic acid as substrate preincubated for 30 mins before substrate addition measured after 30 mins [AID675699, Type: Literature] [gi:317373262]
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45
[SID123101062]
[CID52949921]
IC50 0.12Inhibition of human COX-1 [AID539960, Type: Literature] [gi:317373262]
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46
[SID103181124]
[CID22911835]
IC50 0.12Inhibition of human Prostaglandin G/H synthase 1 [AID161333, Type: Literature] [gi:317373262]
View
47
[SID103299681]
[CID18969715]
IC50 0.12Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1 [AID161343, Type: other] [gi:317373262]
View
48
[SID103297833]
[CID9851770]
IC50 0.14Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1 [AID161343, Type: other] [gi:317373262]
View
49
[SID103394219]
[CID9858164]
IC50 0.14Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 production [AID282431, Type: Literature] [gi:317373262]
View
50
[SID124963936]
[CID9909642]
IC50 0.14Inhibition of human COX1 [AID547805, Type: Literature] [gi:317373262]
View