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NR3C1 (geneid:2908) - Gene BioActivity Data
Also known as: GCCR, GCR, GR, GRL.
BioActivity Outcomes:
Active(3965)
 
 
Inactive(52530)
 
 
Inconclusive(14026)
 
 
Unspecified(2781)
 
 
BioAssay Types:
Confirmatory(46385)
 
 
 
 
Summary(20992)
 
 
 
 
Literature(4927)
 
 
 
 
 
Screening(14)
 
 
 
BioActivity Types:
Potency(37204)
 
 
 
 
IC50(2455)
 
 
 
 
 
EC50(814)
 
 
 
 
 
Ki(540)
 
 
 
 
Substance Types:
Chemical(73294)
 
 
 
 
 
RNAi(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 491    Data Row: 73302   Total Pages: 1467   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103539175]
[CID444036]
IC50 7.5e-05Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesis [AID629915, Type: Literature] [gi:121069]
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2
[SID124966655]
[CID53321912]
IC50 7.94e-05Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature] [gi:121069]
View
3
[SID103282420]
[CID44317747]
Ki 0.0001Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature] [gi:121069]
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4
[SID103281800]
[CID9820558]
Ki 0.0001Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature] [gi:121069]
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5
[SID104234229]
[CID5743]
ED50 0.0001Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay [AID330359, Type: Literature] [gi:121069]
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6
[SID123086577]
[CID55245]
Ki 0.0001Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
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7
[SID103281800]
[CID9820558]
Ki 0.0001Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature] [gi:121069]
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8
[SID103282420]
[CID44317747]
Ki 0.0001Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature] [gi:121069]
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9
[SID103507979]
[CID44420057]
IC50 0.0001Binding affinity to human GR [AID276767, Type: Literature] [gi:121069]
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10
[SID103527549]
[CID17758234]
EC50 0.0001Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
11
[SID103454385]
[CID44396329]
Ki 0.00011Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
12
[SID124958765]
[CID53317966]
IC50 0.000126Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature] [gi:121069]
View
13
[SID103454185]
[CID44396253]
Ki 0.00016Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
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14
[SID103281799]
[CID9819614]
Ki 0.00017Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74224, Type: Literature] [gi:121069]
View
15
[SID103281799]
[CID9819614]
Ki 0.00017Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature] [gi:121069]
View
16
[SID160676237]
[CID70685018]
Ki 0.00017Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
17
[SID103454186]
[CID44396254]
Ki 0.00018Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
18
[SID103527549]
[CID17758234]
IC50 0.0002Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production [AID297839, Type: Literature] [gi:121069]
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19
[SID103527538]
[CID11213029]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
20
[SID103527538]
[CID11213029]
IC50 0.0002Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production [AID297839, Type: Literature] [gi:121069]
View
21
[SID103527539]
[CID11155441]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
22
[SID103527539]
[CID11155441]
IC50 0.0002Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production [AID297839, Type: Literature] [gi:121069]
View
23
[SID103527542]
[CID17758132]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
24
[SID104234229]
[CID5743]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
25
[SID103681669]
[CID45267615]
IC50 0.0002Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
26
[SID124956937]
[CID53317043]
IC50 0.0002Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature] [gi:121069]
View
27
[SID124970675]
[CID11631740]
IC50 0.0002Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay [AID552806, Type: Literature] [gi:121069]
View
28
[SID160708406]
[CID70697572]
Ki 0.00021Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
29
[SID103454384]
[CID44396328]
Ki 0.00022Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
30
[SID103454183]
[CID44396251]
Ki 0.00022Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
31
[SID123086577]
[CID55245]
Ki 0.00024Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature] [gi:121069]
View
32
[SID123086577]
[CID55245]
Ki 0.00024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature] [gi:121069]
View
33
[SID144204256]
[CID441336]
Ratio Potency (uM) 0.000246798qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary] [gi:311348376]
View
34
[SID124967514]
[CID53322313]
IC50 0.000251Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature] [gi:121069]
View
35
[SID103685059]
[CID45269348]
IC50 0.000251Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
36
[SID103685074]
[CID45269354]
IC50 0.000251Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
37
[SID103454243]
[CID44396283]
Ki 0.00027Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
38
[SID103454334]
[CID44396317]
Ki 0.00027Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
39
[SID103527537]
[CID17758014]
EC50 0.0003Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature] [gi:121069]
View
40
[SID103527545]
[CID11453933]
IC50 0.0003Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production [AID297839, Type: Literature] [gi:121069]
View
41
[SID103573417]
[CID44454724]
Ki 0.0003Displacement of [3H]dexamethasone from human recombinant GR [AID318132, Type: Literature] [gi:121069]
View
42
[SID103454244]
[CID44396284]
Ki 0.0003Inhibition of human glucocorticoid receptor [AID238476, Type: Literature] [gi:121069]
View
43
[SID103690334]
[CID24937934]
IC50 0.000316Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
44
[SID103692140]
[CID44517735]
IC50 0.000316Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
45
[SID103693942]
[CID45273670]
IC50 0.000316Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature] [gi:121069]
View
46
[SID124966655]
[CID53321912]
IC50 0.000316Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity [AID568218, Type: Literature] [gi:121069]
View
47
[SID124970196]
[CID53323670]
IC50 0.000316Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature] [gi:121069]
View
48
[SID160672878]
[CID70683527]
IC50 0.00032Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-induced IL8 production [AID659496, Type: Literature] [gi:121069]
View
49
[SID144204249]
[CID54580]
Ratio Potency (uM) 0.00036225qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary] [gi:311348376]
View
50
[SID134442014]
[CID56664884]
EC50 0.00038Agonist activity at GR in human SW1353 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity [AID622345, Type: Literature] [gi:121069]
View