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PADI4 (geneid:23569) - Gene BioActivity Data
Also known as: PAD, PAD4, PADI5, PDI4, PDI5.
BioActivity Outcomes:
Active(1754)
 
 
Inactive(327781)
 
 
Unspecified(45)
 
 
BioAssay Types:
Screening(329317)
 
 
 
Literature(75)
 
 
 
 
Confirmatory(24)
 
 
 
BioActivity Types:
IC50(29)
 
 
 
Ki(1)
 
 
Substance Types:
Chemical(329572)
 
 
 
 
RNAi(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 47    Data Row: 329580   Total Pages: 16479   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118043677]
[CID13891339]
Average IC50 [PAD4] 0.24Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_4, Type: confirmatory] [gi:216548487]
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2
[SID103245838]
[CID13891339]
IC50 0.24Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature] [gi:296439260]
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3
[SID118043681]
[CID51049631]
Average IC50 [PAD4] 0.56Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 21 against PAD1-4 [AID588486_4, Type: confirmatory] [gi:216548487]
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4
[SID118043663]
[CID21771691]
Average IC50 [PAD4] 0.64Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471_4, Type: confirmatory] [gi:216548487]
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5
[SID103245835]
[CID21771691]
IC50 0.64Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature] [gi:296439260]
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6
[SID117695964]
[CID13891338]
Average IC50 [PAD4] 0.88Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 1 against PAD1-4 [AID588438_4, Type: confirmatory] [gi:216548487]
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7
[SID118043674]
[CID253688]
Average IC50 [PAD4] 1Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472_4, Type: confirmatory] [gi:216548487]
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8
[SID103245979]
[CID253688]
IC50 1Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature] [gi:296439260]
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9
[SID103171673]
[CID5351165]
IC50 2.5Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature] [gi:296439260]
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10
[SID11532976]
[CID5323583]
Average IC50 2.5Fluorescence-based biochemical dose response assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID492970, Type: confirmatory] [gi:216548487]
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11
[SID163326132]
[CID24970878]
IC50 5.9Inhibition of PAD4 (unknown origin) [AID725673, Type: Literature] [gi:296439260]
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12
[SID103245835]
[CID21771691]
Ki 20.1Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069613, Type: Literature] [gi:296439260]
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13
[SID103245838]
[CID13891339]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of catalase [AID1069598, Type: Literature] [gi:296439260]
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14
[SID103245838]
[CID13891339]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of superoxide dismutase [AID1069600, Type: Literature] [gi:296439260]
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15
[SID103245838]
[CID13891339]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis [AID1069604, Type: Literature] [gi:296439260]
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16
[SID103245838]
[CID13891339]
Competitive inhibition of recombinant wild-type PAD4 (unknown origin) at 1 to 50 uM by fluorescence polarization-ABPP assay in presence of RFA [AID1069606, Type: Literature] [gi:296439260]
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17
[SID51087080]
[CID18578589]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening] [gi:216548487]
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18
[SID49668320]
[CID3501972]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening] [gi:216548487]
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19
[SID103171673]
[CID5351165]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of catalase [AID1069598, Type: Literature] [gi:296439260]
View
20
[SID103171673]
[CID5351165]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of superoxide dismutase [AID1069600, Type: Literature] [gi:296439260]
View