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ESR1 (geneid:2099) - Gene BioActivity Data
Also known as: RP1-130E4.1, ER, ESR, ESRA, ESTRR, Era, NR3A1.
BioActivity Outcomes:
Active(9503)
 
 
Inactive(234095)
 
 
Inconclusive(12662)
 
 
Unspecified(4647)
 
 
BioAssay Types:
Screening(172232)
 
 
 
 
Confirmatory(50401)
 
 
 
 
 
Summary(31458)
 
 
 
 
Literature(6648)
 
 
 
 
 
BioActivity Types:
Potency(79118)
 
 
 
 
IC50(3147)
 
 
 
 
 
EC50(631)
 
 
 
 
 
Ki(231)
 
 
 
 
Kd(19)
 
 
Substance Types:
Chemical(260895)
 
 
 
 
 
RNAi(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 855    Data Row: 260907   Total Pages: 13046   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124958427]
[CID9996764]
EC50 4e-06Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells [AID103553, Type: Literature] [gi:544257]
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2
[SID103189263]
[CID5757]
EC50 4e-06Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707063, Type: Literature] [gi:544257]
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3
[SID103189263]
[CID5757]
ED50 4.56e-06Functional ERalpha receptor activity in transcriptional activation assay in MCF-7 cells [AID70194, Type: Literature] [gi:544257]
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4
[SID103189263]
[CID5757]
EC50 7e-06Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alpha [AID70188, Type: Literature] [gi:544257]
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5
[SID103164490]
[CID448537]
EC50 7e-06In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pM [AID102438, Type: Literature] [gi:544257]
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6
[SID103189263]
[CID5757]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature] [gi:544257]
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7
[SID103189263]
[CID5757]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature] [gi:544257]
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8
[SID103189263]
[CID5757]
EC50 1e-05Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporter [AID257302, Type: Literature] [gi:544257]
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9
[SID103259865]
[CID155435]
Ki 1.5e-05Apparent binding affinity against estradiol-stimulated T-47D cell proliferation [AID210119, Type: Literature] [gi:544257]
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10
[SID103260302]
[CID9873952]
Ki 1.6e-05Apparent binding affinity against estradiol-stimulated T-47D cell proliferation [AID210119, Type: Literature] [gi:544257]
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11
[SID103189263]
[CID5757]
EC50 1.9e-05Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30 mins at RT [AID254648, Type: Literature] [gi:544257]
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12
[SID103260302]
[CID9873952]
Ki 2.3e-05Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiol [AID90961, Type: Literature] [gi:544257]
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13
[SID103726448]
[CID21628493]
EC50 2.8e-05Estrogenic activity at ERalpha in human Ishikawa cells assessed as stimulation of alkaline phosphatase activity after 4 days by microplate scanning spectrophotometry [AID459056, Type: Literature] [gi:544257]
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14
[SID103259913]
[CID9804157]
Ki 2.8e-05Apparent binding affinity against estradiol-stimulated T-47D cell proliferation [AID210119, Type: Literature] [gi:544257]
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15
[SID103170049]
[CID5035]
Ki 3e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature] [gi:544257]
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16
[SID103189263]
[CID5757]
EC50 3.01e-05Induction of pS2 Gene expression in human MCF-7 cells [AID103551, Type: Literature] [gi:544257]
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17
[SID103169566]
[CID449459]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature] [gi:544257]
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18
[SID103259865]
[CID155435]
Ki 4.2e-05Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature] [gi:544257]
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19
[SID103259865]
[CID155435]
Ki 4.7e-05Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature] [gi:544257]
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20
[SID103189263]
[CID5757]
EC50 4.7e-05Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolism of p-nitrophenol phosphatase after 72 hrs [AID333509, Type: Literature] [gi:544257]
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