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EPAS1 (geneid:2034) - Gene BioActivity Data
Also known as: ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73.
BioActivity Outcomes:
Active(3993)
 
 
Inactive(362849)
 
 
Inconclusive(2)
 
 
Unspecified(1114)
 
 
BioAssay Types:
Screening(365927)
 
 
 
Confirmatory(1932)
 
 
 
 
Literature(99)
 
 
 
 
 
BioActivity Types:
IC50(1932)
 
 
 
 
Kd(22)
 
 
 
EC50(22)
 
 
 
 
Substance Types:
Chemical(367951)
 
 
 
 
RNAi(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 367958   Total Pages: 7360   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164133446]
[CID70697712]
Kd 0.09Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
2
[SID164144653]
[CID71575455]
Kd 0.16Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
3
[SID164139102]
[CID2842377]
Kd 0.17Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
4
[SID164141863]
[CID71575558]
Kd 0.17Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
5
[SID110067538]
[CID50898044]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
6
[SID110067542]
[CID50898039]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
7
[SID103061877]
[CID666941]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
8
[SID103061905]
[CID1994282]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
9
[SID103061912]
[CID1943900]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
10
[SID103061963]
[CID2037423]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
11
[SID103061971]
[CID3159504]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
12
[SID103061973]
[CID666941]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
13
[SID110067516]
[CID50898046]
IC50_Mean_HIF2a (PANC cells) 0.19SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
14
[SID4254515]
[CID972733]
IC50_HIF-2a_PANC_Mean 0.19Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
15
[SID49675252]
[CID854968]
IC50_HIF-2a_PANC_Mean 0.247Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
16
[SID22411729]
[CID15945494]
IC50_HIF-2a_PANC_Mean 0.25Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
17
[SID49665726]
[CID2767825]
IC50_1_HIF-1a 0.274Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View
18
[SID49725274]
[CID1991339]
IC50_HIF-2a_PANC_Mean 0.3Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
19
[SID865680]
[CID666941]
IC50_HIF-2a_PANC_Mean 0.3Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
20
[SID17510599]
[CID9657888]
IC50_HIF-2a_PANC_Mean 0.3Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
21
[SID164144652]
[CID71575556]
Kd 0.37Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
22
[SID26660824]
[CID6902747]
IC50_HIF-2a_PANC_Mean 0.378Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
23
[SID24824544]
[CID2767852]
IC50_1_HIF-1a 0.397Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View
24
[SID164141869]
[CID46368536]
Kd 0.4Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
25
[SID22414953]
[CID4592654]
IC50_HIF-2a_PANC_Mean 0.417Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
26
[SID4249581]
[CID3243514]
IC50_HIF-2a_PANC_Mean 0.447Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
27
[SID22411729]
[CID15945494]
IC50_1_HIF-1a 0.486Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View
28
[SID164136222]
[CID71575229]
Kd 0.5Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
29
[SID858142]
[CID659499]
IC50_HIF-2a_PANC_Mean 0.506Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
30
[SID164127780]
[CID71575340]
Kd 0.54Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
31
[SID103061910]
[CID1994219]
IC50_Mean_HIF2a (PANC cells) 0.573SAR Analysis small molecule inhibitors of HIF-1a in a panel assay [AID652011, Type: confirmatory] [gi:40254439]
View
32
[SID164127781]
[CID2836651]
Kd 0.64Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
33
[SID103479428]
[CID9817550]
EC50 0.7Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay [AID707849, Type: Literature] [gi:32470617]
View
34
[SID85198232]
[CID24896921]
IC50_HIF-2a_PANC_Mean 0.7Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
35
[SID24792303]
[CID907197]
IC50_HIF-2a_PANC_Mean 0.708Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
36
[SID17416347]
[CID5710160]
IC50_HIF-2a_PANC_Mean 0.711Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
37
[SID164133445]
[CID71575557]
Kd 0.73Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
38
[SID14735515]
[CID9550743]
IC50_HIF-2a_PANC_Mean 0.787Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
39
[SID14722386]
[CID774798]
IC50_HIF-2a_PANC_Mean 0.796Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
40
[SID49829119]
[CID6351343]
IC50_1_HIF-1a 0.824Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View
41
[SID24797240]
[CID900837]
IC50_HIF-2a_PANC_Mean 0.92Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
42
[SID49735234]
[CID23605826]
IC50_HIF-2a_PANC_Mean 0.975Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
43
[SID17505190]
[CID9633427]
IC50_HIF-2a_PANC_Mean 1Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
44
[SID164136227]
[CID2836622]
Kd 1.1Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
45
[SID164147447]
[CID71575555]
Kd 1.1Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis [AID723542, Type: Literature] [gi:32470617]
View
46
[SID49829119]
[CID6351343]
IC50_HIF-2a_PANC_Mean 1.12Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
47
[SID24824544]
[CID2767852]
IC50_HIF-2a_PANC_Mean 1.14Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory] [gi:40254439]
View
48
[SID103616847]
[CID21589810]
EC50 1.2Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay [AID707849, Type: Literature] [gi:32470617]
View
49
[SID49647507]
[CID1757603]
IC50_1_HIF-1a 1.228Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View
50
[SID49735234]
[CID23605826]
IC50_1_HIF-1a 1.263Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory] [gi:40254439]
View