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CHRM5 (geneid:1133) - Gene BioActivity Data
Also known as: HM5.
BioActivity Outcomes:
Probe(3)
 
 
Active(4366)
 
 
Inactive(1088579)
 
 
Inconclusive(14)
 
 
Unspecified(1305)
 
 
BioAssay Types:
Screening(1092507)
 
 
 
Literature(737)
 
 
 
 
 
Confirmatory(77)
 
 
 
 
 
 
BioActivity Types:
IC50(935)
 
 
 
 
Ki(254)
 
 
 
 
EC50(142)
 
 
 
 
 
 
Potency(5)
 
 
Kd(2)
 
 
Substance Types:
Chemical(1094260)
 
 
 
 
 
 
RNAi(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 150    Data Row: 1094267   Total Pages: 21886   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID137294184]
[CID57525860]
Average_EC50_uM 0.55Discovery of Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor M5: CRC Assay [AID651878, Type: confirmatory] [gi:20373106]
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2
[SID137294184]
[CID57525860]
Average_EC50_uM_hM5 0.589Discovery of Selective Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor (M5) in CHO cells expressing human M5 receptor [AID651927, Type: confirmatory] [gi:20373106]
View
3
[SID137294184]
[CID57525860]
ML326 M5 PAM Competition in Radioligand Binding assays (Eurofins PanLabs) [AID651832, Type: other] [gi:20373106]
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4
[SID92845376]
[CID45281794]
Cmpd EC50 5.71e-12Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
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5
[SID92845379]
[CID45281797]
Cmpd EC50 6.06e-12Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
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6
[SID103564544]
[CID15057855]
Ki 2.66e-05Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627083, Type: Literature] [gi:543761]
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7
[SID85285486]
[CID42633508]
Cmpd EC50 3.68e-05Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
View
8
[SID103564544]
[CID15057855]
IC50 0.0001Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
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9
[SID103688430]
[CID11519741]
IC50 0.000158Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
View
10
[SID136934113]
[CID16065403]
Ki 0.000169Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627083, Type: Literature] [gi:543761]
View
11
[SID103771010]
[CID11693]
IC50 0.0002Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
View
12
[SID103509360]
[CID71183]
Ki 0.000209Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
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13
[SID103509360]
[CID71183]
Ki 0.000209Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
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14
[SID163312392]
[CID174174]
Ki 0.00021Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as increase in acetylcholine potency at 30 uM by calcium mobilization-based ACh concentration-response curve assay relative to control [AID371750, Type: Literature] [gi:543761]
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15
[SID103771007]
[CID49800046]
IC50 0.000446DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
16
[SID163312392]
[CID174174]
Ki 0.00054Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5 [AID142153, Type: Literature] [gi:543761]
View
17
[SID103276085]
[CID3014059]
IC50 0.00083Displacement of radiolabeled 4DAMP from human muscarinic M5 receptor [AID346433, Type: Literature] [gi:543761]
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18
[SID163312392]
[CID174174]
IC50 0.000922DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
19
[SID163312392]
[CID174174]
Ki 0.001Displacement of [3H]-4-DAMP from human muscarinic M5 receptor expressed in BHK-21 cells [AID511609, Type: Literature] [gi:543761]
View
20
[SID123090243]
[CID31098]
Ki 0.00104Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627083, Type: Literature] [gi:543761]
View
21
[SID104234160]
[CID187]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511603, Type: Literature] [gi:543761]
View
22
[SID104234160]
[CID187]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672153, Type: Literature] [gi:543761]
View
23
[SID103705599]
[CID44627857]
Ki 0.00155Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
24
[SID160679293]
[CID57326234]
Ki 0.0017Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
25
[SID160674005]
[CID70683998]
Ki 0.00182Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
26
[SID123083191]
[CID1201549]
IC50 0.00202DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
27
[SID103463555]
[CID443879]
Ki 0.0022Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells [AID320807, Type: Literature] [gi:543761]
View
28
[SID103435149]
[CID444031]
Ki 0.0023Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5 [AID142153, Type: Literature] [gi:543761]
View
29
[SID103318016]
[CID3042]
IC50 0.00238DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
30
[SID103680163]
[CID45259188]
Ki 0.00302Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells [AID408652, Type: Literature] [gi:543761]
View
31
[SID103376533]
[CID4634]
IC50 0.00322DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
32
[SID103705611]
[CID44627853]
Ki 0.00331Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
33
[SID103173872]
[CID2913]
IC50 0.00384DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
34
[SID160684654]
[CID42596928]
Ki 0.00437Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
35
[SID103189029]
[CID4927]
IC50 0.0046DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
36
[SID160695491]
[CID56965017]
Ki 0.00537Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
37
[SID103705585]
[CID44627740]
Ki 0.00708Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
38
[SID103188772]
[CID2160]
IC50 0.00802DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
39
[SID103605085]
[CID26987]
IC50 0.00837DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
40
[SID103169151]
[CID5452]
IC50 0.00925DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
41
[SID103345443]
[CID8816]
IC50 0.01DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
42
[SID103705598]
[CID44627745]
Ki 0.01148Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
43
[SID103555930]
[CID5572]
IC50 0.012DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
44
[SID103705673]
[CID44627859]
Ki 0.01202Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
45
[SID104244531]
[CID24967746]
EC50 0.01259Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay [AID502827, Type: Literature] [gi:543761]
View
46
[SID103165765]
[CID2818]
IC50 0.013DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other] [gi:543761]
View
47
[SID103376533]
[CID4634]
Ki 0.01413Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
48
[SID103705568]
[CID44627851]
Ki 0.01549Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
49
[SID103574119]
[CID44455198]
Ki 0.0175Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells [AID320807, Type: Literature] [gi:543761]
View
50
[SID103771052]
[CID5284456]
Ki 0.0176Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells [AID723848, Type: Literature] [gi:543761]
View