Bookmark and Share
CHRM5 (geneid:1133) - Gene BioActivity Data
Also known as: HM5.
BioActivity Outcomes:
Probe(4)
 
 
Active(4415)
 
 
Inactive(1088650)
 
 
Inconclusive(22)
 
 
Unspecified(1384)
 
 
BioAssay Types:
Screening(1092574)
 
 
 
Confirmatory(986)
 
 
 
 
 
 
Literature(887)
 
 
 
 
 
BioActivity Types:
IC50(965)
 
 
 
 
 
Ki(304)
 
 
 
 
 
EC50(153)
 
 
 
 
 
 
Potency(5)
 
 
Kd(2)
 
 
Substance Types:
Chemical(1094463)
 
 
 
 
 
 
RNAi(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 178    Data Row: 1094475   Total Pages: 54724   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164186823]
[CID42519285]
Average_IC50_uM 0.44Discovery of Novel Antagonists of Muscarinic Receptor M5: CRC Assay [AID743110, Type: confirmatory] [gi:20373106]
View
2
[SID137294184]
[CID57525860]
Average_EC50_uM 0.55Discovery of Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor M5: CRC Assay [AID651878, Type: confirmatory] [gi:20373106]
View
3
[SID137294184]
[CID57525860]
Average_EC50_uM_hM5 0.589Discovery of Selective Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor (M5) in CHO cells expressing human M5 receptor [AID651927, Type: confirmatory] [gi:20373106]
View
4
[SID137294184]
[CID57525860]
ML326 M5 PAM Competition in Radioligand Binding assays (Eurofins PanLabs) [AID651832, Type: other] [gi:20373106]
View
5
[SID92845376]
[CID45281794]
Cmpd EC50 5.71e-12Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
View
6
[SID92845379]
[CID45281797]
Cmpd EC50 6.06e-12Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
View
7
[SID103564544]
[CID15057855]
Ki 2.66e-05Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627083, Type: Literature] [gi:543761]
View
8
[SID85285486]
[CID42633508]
Cmpd EC50 3.68e-05Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay [AID2186, Type: confirmatory] [gi:20373106]
View
9
[SID103564544]
[CID15057855]
IC50 0.0001Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
View
10
[SID163312392]
[CID174174]
Ki 0.00014Antagonist activity at muscarinic M5 receptor (unknown origin) by PDSP assay [AID757595, Type: Literature] [gi:543761]
View
11
[SID174510050]
[CID154417]
Ki 0.00014Antagonist activity at muscarinic M5 receptor (unknown origin) by PDSP assay [AID757595, Type: Literature] [gi:543761]
View
12
[SID103688430]
[CID11519741]
IC50 0.000158Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
View
13
[SID136934113]
[CID16065403]
Ki 0.000169Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627083, Type: Literature] [gi:543761]
View
14
[SID103771010]
[CID11693]
IC50 0.0002Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539983, Type: Literature] [gi:543761]
View
15
[SID103509360]
[CID71183]
Ki 0.000209Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting [AID445081, Type: Literature] [gi:543761]
View
16
[SID103509360]
[CID71183]
Ki 0.000209Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting [AID668959, Type: Literature] [gi:543761]
View
17
[SID163312392]
[CID174174]
Ki 0.00021Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as increase in acetylcholine potency at 30 uM by calcium mobilization-based ACh concentration-response curve assay relative to control [AID371750, Type: Literature] [gi:543761]
View
18
[SID174510050]
[CID154417]
Ki 0.000339Displacement of [3H]QNB from muscarinic M5 receptor (unknown origin) [AID1063771, Type: Literature] [gi:543761]
View
19
[SID103771007]
[CID49800046]
IC50 0.000446DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: confirmatory] [gi:543761]
View
20
[SID103276085]
[CID3014059]
IC50 0.00045Binding affinity to human muscarinic M5 receptor by radioligand displacement assay [AID751874, Type: Literature] [gi:543761]
View