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CHRM1 (geneid:1128) - Gene BioActivity Data
Also known as: HM1, M1, M1R.
BioActivity Outcomes:
Active(7572)
 
 
Inactive(1072580)
 
 
Inconclusive(54)
 
 
Unspecified(2244)
 
 
BioAssay Types:
Screening(1078459)
 
 
 
 
Literature(2976)
 
 
 
 
 
Confirmatory(943)
 
 
 
 
BioActivity Types:
IC50(1465)
 
 
 
 
 
Ki(454)
 
 
 
 
 
EC50(365)
 
 
 
 
 
Kd(36)
 
 
 
Potency(9)
 
 
 
Substance Types:
Chemical(1082437)
 
 
 
 
 
RNAi(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 385    Data Row: 1082450   Total Pages: 54123   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160703269]
[CID46174144]
Kd 3.98e-06Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430442, Type: Literature] [gi:113118]
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2
[SID103564544]
[CID15057855]
Ki 1.3e-05Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627077, Type: Literature] [gi:113118]
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3
[SID194172374]
[CID44232952]
Kd 1.58e-05Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430442, Type: Literature] [gi:113118]
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4
[SID103564544]
[CID15057855]
IC50 3.16e-05Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
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5
[SID160703269]
[CID46174144]
Ki 5e-05Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assay [AID600363, Type: Literature] [gi:113118]
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6
[SID160703269]
[CID46174144]
Ki 5.01e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cell membrane [AID430444, Type: Literature] [gi:113118]
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7
[SID103509360]
[CID71183]
Ki 9.55e-05Displacement of [3H]NMS from EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 22 hrs by liquid scintillation counting [AID714458, Type: Literature] [gi:113118]
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8
[SID103688430]
[CID11519741]
IC50 0.0001Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
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9
[SID194172374]
[CID44232952]
Ki 0.0001Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cell membrane [AID430444, Type: Literature] [gi:113118]
View
10
[SID136934113]
[CID16065403]
Ki 0.000115Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627077, Type: Literature] [gi:113118]
View
11
[SID103680092]
[CID45259193]
Kd 0.000126Antagonist activity at human muscarinic acetylcholine M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362476, Type: Literature] [gi:113118]
View
12
[SID103771010]
[CID11693]
IC50 0.000126Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
View
13
[SID103688428]
[CID44233399]
IC50 0.00014Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
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14
[SID103688430]
[CID11519741]
IC50 0.00014Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
15
[SID103691893]
[CID10143955]
IC50 0.00015Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
16
[SID103691873]
[CID44233402]
IC50 0.00016Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
17
[SID103632654]
[CID11519069]
Ki 0.00016Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay [AID414942, Type: Literature] [gi:113118]
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18
[SID103509360]
[CID71183]
Ki 0.00017Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 [AID714454, Type: Literature] [gi:113118]
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19
[SID103693696]
[CID44232931]
IC50 0.00019Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
20
[SID103604323]
[CID11504490]
Kd 0.0002Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay [AID414362, Type: Literature] [gi:113118]
View