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CHRM1 (geneid:1128) - Gene BioActivity Data
Also known as: HM1, M1, M1R.
BioActivity Outcomes:
Active(7552)
 
 
Inactive(1072568)
 
 
Inconclusive(53)
 
 
Unspecified(2213)
 
 
BioAssay Types:
Screening(1078459)
 
 
 
 
Literature(2913)
 
 
 
 
 
Confirmatory(944)
 
 
 
 
BioActivity Types:
IC50(1468)
 
 
 
 
 
Ki(452)
 
 
 
 
 
EC50(359)
 
 
 
 
 
Kd(37)
 
 
 
Potency(9)
 
 
 
Substance Types:
Chemical(1082373)
 
 
 
 
 
RNAi(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 371    Data Row: 1082386   Total Pages: 54120   Display: Page     
Sort: [Click the result table header to sort]
#StructureSubstanceCompoundActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160703269]
[CID46174144]
Kd 3.98e-06Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430442, Type: Literature] [gi:113118]
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2
[SID103693926]
[CID45273660]
Kd 3.98e-06Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430442, Type: Literature] [gi:113118]
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3
[SID103564544]
[CID15057855]
Ki 1.3e-05Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627077, Type: Literature] [gi:113118]
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4
[SID103685036]
[CID45269338]
Kd 1.58e-05Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430442, Type: Literature] [gi:113118]
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5
[SID103564544]
[CID15057855]
IC50 3.16e-05Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
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6
[SID103693926]
[CID45273660]
Ki 5e-05Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assay [AID600363, Type: Literature] [gi:113118]
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7
[SID160703269]
[CID46174144]
Ki 5e-05Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assay [AID600363, Type: Literature] [gi:113118]
View
8
[SID103693926]
[CID45273660]
Ki 5.01e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cell membrane [AID430444, Type: Literature] [gi:113118]
View
9
[SID160703269]
[CID46174144]
Ki 5.01e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cell membrane [AID430444, Type: Literature] [gi:113118]
View
10
[SID103509360]
[CID71183]
Ki 9.55e-05Displacement of [3H]NMS from EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 22 hrs by liquid scintillation counting [AID714458, Type: Literature] [gi:113118]
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11
[SID103688430]
[CID11519741]
IC50 0.0001Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
View
12
[SID103685036]
[CID45269338]
Ki 0.0001Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cell membrane [AID430444, Type: Literature] [gi:113118]
View
13
[SID136934113]
[CID16065403]
Ki 0.000115Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627077, Type: Literature] [gi:113118]
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14
[SID103680092]
[CID45259193]
Kd 0.000126Antagonist activity at human muscarinic acetylcholine M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362476, Type: Literature] [gi:113118]
View
15
[SID103771010]
[CID11693]
IC50 0.000126Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539980, Type: Literature] [gi:113118]
View
16
[SID103688428]
[CID44233399]
IC50 0.00014Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
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17
[SID103688430]
[CID11519741]
IC50 0.00014Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
18
[SID103691893]
[CID10143955]
IC50 0.00015Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
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19
[SID103691873]
[CID44233402]
IC50 0.00016Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting [AID430616, Type: Literature] [gi:113118]
View
20
[SID103632654]
[CID11519069]
Ki 0.00016Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay [AID414942, Type: Literature] [gi:113118]
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