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mitogen-activated protein kinase 3 isoform 1.. [gi:91718899] - Target BioActivity Data
Also known as: mitogen-activated protein kinase 3 isoform 1 [Homo sapiens].
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BioActivity Outcomes:
Active(125)
 
 
BioAssay Types:
Literature(106)
 
 
Confirmatory(3)
 
 
BioActivity Types:
IC50(58)
 
 
Kd(4)
 
 
AC50(3)
 
 
Substance Types:
Chemical(125)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 44    Data Row: 125   Total Pages: 3   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103320641]
[CID10303277]
IC50 1e-05Inhibit ion of MAPK phosphorylation in LoVo cells [AID102178, Type: Literature]
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2
[SID103643051]
[CID44587047]
IC50 0.007Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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3
[SID103643282]
[CID11653652]
IC50 0.009Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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4
[SID103643283]
[CID11639637]
IC50 0.01Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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5
[SID103643052]
[CID44587048]
IC50 0.017Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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6
[SID103642964]
[CID44586991]
IC50 0.018Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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7
[SID103643343]
[CID44587235]
IC50 0.018Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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8
[SID103643280]
[CID11660270]
IC50 0.02Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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9
[SID103643224]
[CID11566757]
IC50 0.022Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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10
[SID103643223]
[CID44587190]
IC50 0.026Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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11
[SID103642962]
[CID11616462]
IC50 0.033Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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12
[SID103643050]
[CID11545261]
IC50 0.037Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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13
[SID103643341]
[CID11624965]
IC50 0.048Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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14
[SID103642961]
[CID11522118]
IC50 0.053Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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15
[SID103643474]
[CID11500476]
IC50 0.056Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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16
[SID103642965]
[CID11523321]
IC50 0.057Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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17
[SID103643222]
[CID11717001]
IC50 0.063Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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18
[SID103643226]
[CID11667128]
IC50 0.119Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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19
[SID103643281]
[CID44587211]
IC50 0.122Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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20
[SID103643342]
[CID44587234]
IC50 0.154Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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21
[SID103642963]
[CID11536794]
IC50 0.165Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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22
[SID103643225]
[CID44587191]
IC50 0.171Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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23
[SID103643049]
[CID44587046]
IC50 0.245Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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24
[SID103465817]
[CID44401410]
IC50 0.3Inhibitory concentration against Extracellular signal-regulated kinase 1 [AID240856, Type: Literature]
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25
[SID103643340]
[CID11610758]
IC50 0.332Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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26
[SID103203835]
[CID10324074]
IC50 0.38Inhibit ion of MAPK phosphorylation in LoVo cells [AID102178, Type: Literature]
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27
[SID103495052]
[CID16043304]
IC50 0.4Inhibition of ERK1 [AID269867, Type: Literature]
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28
[SID103583785]
[CID16038120]
Kd 0.43Binding constant for ERK1 kinase domain [AID624885, Type: Literature]
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29
[SID103643053]
[CID44587049]
IC50 0.569Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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30
[SID103643279]
[CID44587210]
IC50 0.607Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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31
[SID103465963]
[CID44401506]
IC50 0.75Inhibitory concentration against Extracellular signal-regulated kinase 1 [AID240856, Type: Literature]
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32
[SID103582308]
IC50 0.774DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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33
[SID103643471]
[CID44587295]
IC50 0.8Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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34
[SID103748183]
[CID46203864]
IC50 0.98Inhibition of human ERK1 [AID472891, Type: Literature]
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35
[SID103643418]
[CID44587274]
IC50 1Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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36
[SID164132841]
[CID5703619]
IC50 1.146Inhibition of ERK1 (unknown origin) after 10 mins by mobility shift assay [AID739292, Type: Literature]
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37
[SID124964703]
[CID10361267]
IC50 1.4Inhibition of human recombinant ERK1 expressed in E.coli after 30 mins [AID568306, Type: Literature]
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38
[SID103643472]
[CID44587296]
IC50 1.5Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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39
[SID103250959]
[CID3117]
IC50 1.51DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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40
[SID103643543]
[CID25093326]
IC50 1.9Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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41
[SID103643416]
[CID44587273]
IC50 2.4Inhibition of ERK1/2 phosphorylation in human MALME3M cells [AID362269, Type: Literature]
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42
[SID103171247]
[CID3598]
IC50 2.4844DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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43
[SID103291875]
[CID6238]
IC50 3.157DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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44
[SID103192479]
[CID448991]
IC50 3.333Inhibition of human Erk1 [AID415769, Type: Literature]
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45
[SID103600468]
[CID16129778]
IC50 4.052DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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46
[SID103183576]
[CID5717]
IC50 4.376DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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47
[SID160696671]
IC50 4.624DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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48
[SID103243222]
[CID44299148]
IC50 4.9Inhibition of ERK1 [AID269867, Type: Literature]
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49
[SID103377543]
[CID5624]
IC50 4.962DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
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50
[SID103293005]
[CID3728]
IC50 5.264DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]
View