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mitogen-activated protein kinase 1 [Homo sapi.. [gi:66932916] - Target BioActivity Data
Also known as: mitogen-activated protein kinase 1 [Homo sapiens].
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BioActivity Outcomes:
Active(1521)
 
 
BioAssay Types:
Confirmatory(1332)
 
 
Literature(150)
 
 
BioActivity Types:
Potency(1332)
 
 
IC50(68)
 
 
Ki(39)
 
 
Kd(8)
 
 
Substance Types:
Chemical(1521)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 66    Data Row: 1521   Total Pages: 31   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103320641]
[CID10303277]
IC50 1e-05Inhibit ion of MAPK phosphorylation in LoVo cells [AID102178, Type: Literature]
View
2
[SID14729642]
[CID9550014]
Potency 0.0004qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
View
3
[SID103509149]
[CID16115004]
Ki 0.002Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
4
[SID103243222]
[CID44299148]
IC50 0.0025Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
View
5
[SID103396349]
[CID3036831]
IC50 0.006Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
View
6
[SID103450226]
[CID3035462]
IC50 0.006In vitro inhibitory concentration against human mitogen-activated protein kinase-1 (MEK-1) by using [gamma-33P]-ATP] as radioligand [AID242417, Type: Literature]
View
7
[SID103509144]
[CID23647177]
Ki 0.006Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
8
[SID103509143]
[CID23647176]
Ki 0.007Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
9
[SID103450226]
[CID3035462]
IC50 0.009Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
View
10
[SID103509114]
[CID23647171]
Ki 0.014Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
11
[SID103509139]
[CID23647175]
Ki 0.022Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
12
[SID103509131]
[CID23647174]
Ki 0.024Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
13
[SID103509172]
[CID23647165]
Ki 0.035Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
14
[SID11114011]
[CID2051]
Potency 0.0398Confirmation Concentration-Response Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1725, Type: confirmatory]
View
15
[SID103509113]
[CID23647158]
Ki 0.04Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
16
[SID103509120]
[CID23647172]
Ki 0.044Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
17
[SID103509109]
[CID23647170]
Ki 0.063Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
18
[SID103509202]
[CID23647154]
Ki 0.086Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
19
[SID103351586]
[CID9882612]
IC50 0.089In vitro inhibitory concentration against human mitogen-activated protein kinase-1 (MEK-1) by using [gamma-33P]-ATP] as radioligand [AID242417, Type: Literature]
View
20
[SID103509142]
[CID23647163]
Ki 0.1Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
21
[SID11114011]
[CID2051]
Potency 0.1qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
View
22
[SID11113872]
[CID4705]
Potency 0.1qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
View
23
[SID103509150]
[CID23647178]
Ki 0.15Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
24
[SID103509106]
[CID23647156]
Ki 0.16Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
25
[SID103509136]
[CID23647162]
Ki 0.17Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
26
[SID103600468]
[CID16129778]
IC50 0.185DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
27
[SID103171247]
[CID3598]
IC50 0.196DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
28
[SID11113946]
[CID5354033]
Potency 0.1995qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]
View
29
[SID50104794]
[CID2051]
Potency 0.1995Confirmation Concentration-Response Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1725, Type: confirmatory]
View
30
[SID103509155]
[CID23647149]
Ki 0.2Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
31
[SID136941380]
IC50 0.216DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
32
[SID103533832]
[CID16739279]
Ki 0.22Inhibition of ERK [AID294348, Type: Literature]
View
33
[SID103509098]
[CID23647155]
Ki 0.23Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
34
[SID103509123]
[CID23647173]
Ki 0.24Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
35
[SID50104794]
[CID2051]
Potency 0.2512qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
View
36
[SID103491101]
[CID11314340]
Ki 0.26Inhibition of ERK2 [AID266597, Type: Literature]
View
37
[SID103480444]
[CID11361885]
IC50 0.28Inhibitory activity against p42MAPK [AID259499, Type: Literature]
View
38
[SID11114148]
[CID6604888]
Potency 0.2818Confirmation Concentration-Response Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID1724, Type: confirmatory]
View
39
[SID103293005]
[CID3728]
IC50 0.294DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
40
[SID103583785]
[CID16038120]
Kd 0.3Binding constant for ERK2 kinase domain [AID624713, Type: Literature]
View
41
[SID26719789]
[CID3035187]
Potency 0.3162qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
View
42
[SID26753180]
[CID9549284]
Potency 0.3162qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]
View
43
[SID136935046]
IC50 0.3208DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
44
[SID103509129]
[CID23647161]
Ki 0.33Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View
45
[SID103243222]
[CID44299148]
IC50 0.37Inhibition of ERK2 using 10 uM ATP [AID262365, Type: Literature]
View
46
[SID103243222]
[CID44299148]
IC50 0.37Inhibition of ERK2 at 10 uM ATP [AID262976, Type: Literature]
View
47
[SID103203835]
[CID10324074]
IC50 0.38Inhibit ion of MAPK phosphorylation in LoVo cells [AID102178, Type: Literature]
View
48
[SID103480368]
[CID11407074]
IC50 0.38Inhibitory activity against p42MAPK [AID259499, Type: Literature]
View
49
[SID103206701]
[CID2406]
IC50 0.385DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]
View
50
[SID103509162]
[CID23647151]
Ki 0.43Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
View