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mitogen-activated protein kinase 1 [Homo sapi.. [gi:66932916] - Target BioActivity Data
Also known as: mitogen-activated protein kinase 1 [Homo sapiens].
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BioActivity Outcomes:
Active(1562)
 
 
BioAssay Types:
Confirmatory(1355)
 
 
Literature(193)
 
 
BioActivity Types:
Potency(1332)
 
 
IC50(75)
 
 
Ki(51)
 
 
Kd(9)
 
 
Substance Types:
Chemical(1562)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 77    Data Row: 1562   Total Pages: 79   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103320641]
[CID10303277]
IC50 1e-05Inhibit ion of MAPK phosphorylation in LoVo cells [AID102178, Type: Literature]
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2
[SID174523273]
[CID71555244]
IC50 0.000205Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assay [AID760524, Type: Literature]
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3
[SID174518062]
[CID71555167]
IC50 0.000286Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assay [AID760524, Type: Literature]
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4
[SID14729642]
[CID9550014]
Potency 0.0004qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]
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5
[SID174518061]
[CID71555247]
IC50 0.000851Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assay [AID760524, Type: Literature]
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6
[SID103509149]
[CID16115004]
Ki 0.002Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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7
[SID123092436]
[CID44259]
IC50 0.0025Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
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8
[SID103509144]
[CID23647177]
Ki 0.006Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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9
[SID103396349]
[CID3036831]
IC50 0.006Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
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10
[SID103450226]
[CID3035462]
IC50 0.006In vitro inhibitory concentration against human mitogen-activated protein kinase-1 (MEK-1) by using [gamma-33P]-ATP] as radioligand [AID242417, Type: Literature]
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11
[SID103509143]
[CID23647176]
Ki 0.007Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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12
[SID103450226]
[CID3035462]
IC50 0.009Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1 [AID126782, Type: Literature]
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13
[SID103509114]
[CID23647171]
Ki 0.014Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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14
[SID103509139]
[CID23647175]
Ki 0.022Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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15
[SID103509131]
[CID23647174]
Ki 0.024Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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16
[SID103509172]
[CID23647165]
Ki 0.035Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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17
[SID11114011]
[CID2051]
Potency 0.0398Confirmation Concentration-Response Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1725, Type: confirmatory]
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18
[SID103509113]
[CID23647158]
Ki 0.04Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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19
[SID103509120]
[CID23647172]
Ki 0.044Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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20
[SID103509109]
[CID23647170]
Ki 0.063Inhibition of ERK2 by spectrophotometric coupled-enzyme assay [AID280275, Type: Literature]
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