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Mitogen-activated protein kinase kinase kinas.. [gi:6685617] - Target BioActivity Data
Also known as: Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5.
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BioActivity Outcomes:
Active(90)
 
 
BioAssay Types:
Literature(55)
 
 
Screening(35)
 
 
BioActivity Types:
IC50(49)
 
 
Kd(4)
 
 
Ki(2)
 
 
Substance Types:
Chemical(90)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 90   Total Pages: 2   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID124975778]
[CID24944925]
IC50 0.014Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
2
[SID163315227]
[CID59175651]
IC50 0.016Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
3
[SID163318751]
[CID59175417]
IC50 0.021Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
4
[SID163332581]
[CID59175292]
IC50 0.021Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
5
[SID163318750]
[CID59175229]
IC50 0.022Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
6
[SID163322186]
[CID59175598]
IC50 0.03Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
7
[SID163339408]
[CID24944928]
IC50 0.032Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
8
[SID163322185]
[CID59175648]
IC50 0.034Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
9
[SID164133368]
[CID71717270]
Kd 0.07Binding constant for ASK1 kinase domain [AID625028, Type: Literature]
View
10
[SID163328995]
[CID59175469]
IC50 0.07Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
11
[SID163328994]
[CID59175319]
IC50 0.082Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
12
[SID103243222]
[CID44299148]
Kd 0.11Binding constant for MAP3K5 kinase domain [AID435412, Type: Literature]
View
13
[SID103243222]
[CID44299148]
Kd 0.11Binding constant for ASK1 kinase domain [AID625028, Type: Literature]
View
14
[SID103243222]
[CID44299148]
Kd 0.12Average Binding Constant for MAP3K5 ; NA=Not Active at 10 uM [AID256579, Type: Literature]
View
15
[SID163318752]
[CID59175460]
IC50 0.129Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
16
[SID164130300]
[CID1589310]
IC50 0.2Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
17
[SID164135938]
[CID1351628]
IC50 0.2Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
18
[SID163318749]
[CID836391]
IC50 0.26Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
19
[SID164138747]
[CID1544033]
IC50 0.3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
20
[SID164133135]
[CID6064827]
IC50 0.3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
21
[SID164132803]
[CID6509439]
Ki 0.34Competitive inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by Lineweaver-Burk plot analysis [AID740394, Type: Literature]
View
22
[SID124975325]
[CID1589389]
IC50 0.35Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
23
[SID164141523]
[CID1351934]
IC50 0.35Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
24
[SID164141524]
[CID44786880]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
25
[SID164141567]
[CID5827971]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
26
[SID164147061]
[CID1589300]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
27
[SID164147110]
[CID44786881]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
28
[SID164147111]
[CID6516664]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
29
[SID164149947]
[CID5828227]
IC50 0.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
30
[SID131271791]
[CID5522952]
Ki 0.5Competitive inhibition of human ASK1 by Lineweaver-Burk plot analysis [AID593703, Type: Literature]
View
31
[SID164132803]
[CID6509439]
IC50 0.65Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
32
[SID164144361]
[CID1641056]
IC50 0.65Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
33
[SID164141566]
[CID23474918]
IC50 0.75Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
34
[SID164149945]
[CID1205717]
IC50 0.75Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
35
[SID164149946]
[CID44786879]
IC50 0.75Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
36
[SID164138789]
[CID71718392]
IC50 0.8Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
37
[SID163332580]
[CID59175418]
IC50 0.87Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
38
[SID164135889]
[CID1368457]
IC50 1Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
39
[SID164147109]
[CID5828229]
IC50 1Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
40
[SID164130242]
[CID1205453]
IC50 1.25Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
41
[SID164135939]
[CID16271725]
IC50 1.8Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
42
[SID164147114]
[CID6509437]
IC50 1.8Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
43
[SID164147112]
[CID1587088]
IC50 2Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
44
[SID164130302]
[CID71716557]
IC50 2.5Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
45
[SID164149983]
[CID5941094]
IC50 2.8Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
46
[SID164147113]
[CID7454869]
IC50 3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
47
[SID164130301]
[CID7454873]
IC50 3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
48
[SID131271791]
[CID5522952]
IC50 3Competitive inhibition of human ASK1 [AID593712, Type: Literature]
View
49
[SID164149982]
[CID44786797]
IC50 3.9Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
View
50
[SID131282302]
[CID793884]
IC50 4.7Competitive inhibition of human ASK1 [AID593712, Type: Literature]
View