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BioActivity Data for Targets
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BioActivity Outcomes:
Probe(2)
 
 
Active(987)
 
 
BioAssay Types:
Confirmatory(763)
 
 
Screening(131)
 
 
Literature(91)
 
 
Summary(2)
 
 
BioActivity Types:
Potency(760)
 
 
IC50(33)
 
 
Ki(31)
 
 
EC50(3)
 
 
Substance Types:
Chemical(989)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 989   Total Pages: 50   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID85267237]
[CID40225210]
qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Summary [AID2593, Type: summary]
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2
[SID89449177]
[CID9893924]
qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Summary [AID2593, Type: summary]
View
3
[SID160667755]
[CID57341115]
Ki 0.0004Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
4
[SID160705314]
[CID57341113]
Ki 0.0018Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
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5
[SID160694594]
[CID57341308]
Ki 0.003Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
6
[SID160667756]
[CID57341304]
Ki 0.004Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
7
[SID163317212]
[CID57522156]
IC50 0.0043Inhibition of lysosomal beta-glucosidase in human fibroblast using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 24 hrs before substrate addition measured after 2 hrs by fluorometry [AID699340, Type: Literature]
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8
[SID160699951]
[CID57341300]
Ki 0.0044Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
9
[SID160689138]
[CID57341302]
Ki 0.006Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
10
[SID160705315]
[CID57341312]
Ki 0.012Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
11
[SID85267413]
[CID447607]
Potency 0.0126qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified Non-mutant Glucocerebrosidase [AID2595, Type: confirmatory]
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12
[SID160678431]
[CID57341111]
Ki 0.018Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
13
[SID160667757]
[CID57341306]
Ki 0.019Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
14
[SID103746535]
[CID46866608]
IC50 0.019Inhibition of human recombinant beta-glucocerebrosidase assessed as p-nitrophenolate accumulation preincubated for 10 mins before p-nitrophenyl-beta-d-glucopyranoside addition measured after 10 mins by fluorescence spectrophotometry [AID474612, Type: Literature]
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15
[SID160688236]
[CID70689494]
Ki 0.026Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2 [AID652473, Type: Literature]
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16
[SID160699950]
[CID57341119]
Ki 0.029Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
17
[SID160673081]
[CID57341314]
Ki 0.03Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
18
[SID160688236]
[CID70689494]
IC50 0.056Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 7 [AID652471, Type: Literature]
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19
[SID85267413]
[CID447607]
Potency 0.0562qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified N370S Glucocerebrosidase [AID2597, Type: confirmatory]
View
20
[SID103485311]
[CID447607]
IC50 0.06Inhibition of human lysosomal beta-glucosidase [AID342801, Type: Literature]
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