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BioActivity Data for Targets
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BioActivity Outcomes:
Probe(2)
 
 
Active(973)
 
 
BioAssay Types:
Confirmatory(763)
 
 
Screening(131)
 
 
Literature(63)
 
 
Summary(2)
 
 
BioActivity Types:
Potency(760)
 
 
IC50(33)
 
 
Ki(23)
 
 
EC50(3)
 
 
Substance Types:
Chemical(975)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 48    Data Row: 975   Total Pages: 20   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID85267237]
[CID40225210]
qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Summary [AID2593, Type: summary]
View
2
[SID89449177]
[CID9893924]
qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Summary [AID2593, Type: summary]
View
3
[SID160667755]
[CID57341115]
Ki 0.0004Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
4
[SID160705314]
[CID57341113]
Ki 0.0018Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
5
[SID160694594]
[CID57341308]
Ki 0.003Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
6
[SID160667756]
[CID57341304]
Ki 0.004Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
7
[SID163317212]
[CID57522156]
IC50 0.0043Inhibition of lysosomal beta-glucosidase in human fibroblast using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 24 hrs before substrate addition measured after 2 hrs by fluorometry [AID699340, Type: Literature]
View
8
[SID160699951]
[CID57341300]
Ki 0.0044Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
9
[SID160689138]
[CID57341302]
Ki 0.006Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
10
[SID160705315]
[CID57341312]
Ki 0.012Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
11
[SID85267413]
[CID447607]
Potency 0.0126qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified Non-mutant Glucocerebrosidase [AID2595, Type: confirmatory]
View
12
[SID160678431]
[CID57341111]
Ki 0.018Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
13
[SID160667757]
[CID57341306]
Ki 0.019Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662915, Type: Literature]
View
14
[SID103746535]
[CID46866608]
IC50 0.019Inhibition of human recombinant beta-glucocerebrosidase assessed as p-nitrophenolate accumulation preincubated for 10 mins before p-nitrophenyl-beta-d-glucopyranoside addition measured after 10 mins by fluorescence spectrophotometry [AID474612, Type: Literature]
View
15
[SID160688236]
[CID70689494]
Ki 0.026Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2 [AID652473, Type: other]
View
16
[SID160699950]
[CID57341119]
Ki 0.029Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
17
[SID160673081]
[CID57341314]
Ki 0.03Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
18
[SID160688236]
[CID70689494]
IC50 0.056Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 7 [AID652471, Type: other]
View
19
[SID85267413]
[CID447607]
Potency 0.0562qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified N370S Glucocerebrosidase [AID2597, Type: confirmatory]
View
20
[SID103485311]
[CID447607]
IC50 0.06Inhibition of human lysosomal beta-glucosidase [AID342801, Type: Literature]
View
21
[SID103485311]
[CID447607]
IC50 0.063Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry [AID613052, Type: Literature]
View
22
[SID85267413]
[CID447607]
Potency 0.0631qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in N370S Spleen Homogenate Using a Red Fluorescent Substrate [AID2613, Type: confirmatory]
View
23
[SID85267413]
[CID447607]
Potency 0.0708qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate [AID2592, Type: confirmatory]
View
24
[SID85267413]
[CID447607]
Potency 0.0716qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Hit Validation [AID2671, Type: confirmatory]
View
25
[SID85267413]
[CID447607]
Potency 0.0716qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]
View
26
[SID160699949]
[CID57341117]
Ki 0.076Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
27
[SID26753329]
[CID5067281]
Potency 0.0794qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified Non-mutant Glucocerebrosidase [AID2595, Type: confirmatory]
View
28
[SID160699082]
[CID70693697]
IC50 0.081Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 7 [AID652471, Type: other]
View
29
[SID85267413]
[CID447607]
Potency 0.0891qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
30
[SID160688236]
[CID70689494]
IC50 0.09Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 5.2 [AID652472, Type: other]
View
31
[SID85267280]
[CID4858520]
Potency 0.1413qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
32
[SID160699082]
[CID70693697]
Ki 0.17Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2 [AID652473, Type: other]
View
33
[SID160694593]
[CID57341109]
Ki 0.18Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
34
[SID160689139]
[CID57341310]
Ki 0.2Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
35
[SID85267291]
[CID17556704]
Potency 0.2239qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
36
[SID85267240]
[CID40225220]
Potency 0.2239qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
37
[SID4264637]
[CID2210290]
Potency 0.2239qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified Non-mutant Glucocerebrosidase [AID2595, Type: confirmatory]
View
38
[SID160689140]
[CID57341492]
Ki 0.25Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Line-Weaver Burk plot analysis at pH 5 [AID662914, Type: Literature]
View
39
[SID85267237]
[CID40225210]
Potency 0.2512qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
40
[SID49715093]
[CID16008216]
Potency 0.2512qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]
View
41
[SID85267234]
[CID26450846]
Potency 0.259qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]
View
42
[SID85267283]
[CID26440749]
Potency 0.259qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]
View
43
[SID124960951]
[CID40225210]
IC50 0.28Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by fluorimetric analysis [AID702063, Type: Literature]
View
44
[SID85267286]
[CID40225288]
Potency 0.2818qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate [AID2588, Type: confirmatory]
View
45
[SID85267237]
[CID40225210]
Potency 0.2818qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate [AID2592, Type: confirmatory]
View
46
[SID49647551]
[CID929654]
Potency 0.2818qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]
View
47
[SID85267381]
[CID44246432]
Potency 0.2906qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]
View
48
[SID85267396]
[CID44246446]
Potency 0.2906qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]
View
49
[SID103567492]
[CID501640]
IC50 0.3Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 7 [AID652471, Type: other]
View
50
[SID103567492]
[CID501640]
Ki 0.3Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2 [AID652473, Type: other]
View