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muscarinic acetylcholine receptor M3 [Homo sa.. [gi:4502819] - Target BioActivity Data
Also known as: muscarinic acetylcholine receptor M3 [Homo sapiens].
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BioActivity Outcomes:
Active(1276)
 
 
BioAssay Types:
Literature(1189)
 
 
Confirmatory(76)
 
 
BioActivity Types:
IC50(599)
 
 
Ki(485)
 
 
Kd(74)
 
 
EC50(35)
 
 
Substance Types:
Chemical(1276)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 108    Data Row: 1276   Total Pages: 64   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103564544]
[CID15057855]
Ki 9.8e-06Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627018, Type: Literature]
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2
[SID103604323]
[CID11504490]
Kd 1e-05Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR based single concentration kinetic assay [AID414359, Type: Literature]
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3
[SID160667544]
[CID11431874]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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4
[SID160667545]
[CID70681419]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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5
[SID160688684]
[CID11271303]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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6
[SID160688900]
[CID11191775]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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7
[SID160694182]
[CID70691874]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
8
[SID160694389]
[CID11431873]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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9
[SID160699512]
[CID11272761]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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10
[SID160699513]
[CID70693915]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
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11
[SID124962416]
[CID9874175]
Ki 1e-05Displacement of [3H]-N-methyl-scopolamine from human muscarinic M3 receptor after 6 hrs by cell based assay [AID578407, Type: Literature]
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12
[SID103564544]
[CID15057855]
Ki 1e-05Antagonist activity at human M3 receptor expressed in CHO cells assessed as inhibition of carbachol-induced response after 30 mins by AP-1-driven luciferase reporter gene assay [AID1056124, Type: Literature]
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13
[SID103680099]
[CID45266399]
Kd 1.26e-05Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362480, Type: Literature]
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14
[SID103564544]
[CID15057855]
Ki 1.58e-05Binding affinity to wild type human M3 receptor expressed in HEK293T cells up to 24 hrs by radioligand displacement assay [AID1056123, Type: Literature]
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15
[SID103693926]
[CID45273660]
Kd 2e-05Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430439, Type: Literature]
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16
[SID160703269]
[CID46174144]
Kd 2e-05Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay [AID430439, Type: Literature]
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17
[SID103680181]
[CID25034183]
Kd 2.51e-05Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362480, Type: Literature]
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18
[SID160667543]
[CID11442668]
Kd 2.51e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
19
[SID103632847]
[CID11533794]
Kd 2.51e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
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20
[SID103604323]
[CID11504490]
Ki 3.16e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay [AID390994, Type: Literature]
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