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muscarinic acetylcholine receptor M3 [Homo sa.. [gi:4502819] - Target BioActivity Data
Also known as: muscarinic acetylcholine receptor M3 [Homo sapiens].
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BioActivity Outcomes:
Active(1196)
 
 
BioAssay Types:
Literature(1084)
 
 
Confirmatory(1)
 
 
BioActivity Types:
IC50(590)
 
 
Ki(442)
 
 
Kd(72)
 
 
EC50(35)
 
 
Substance Types:
Chemical(1196)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 95    Data Row: 1196   Total Pages: 24   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103564544]
[CID15057855]
Ki 9.8e-06Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells after 24 hrs by filter binding assay [AID627018, Type: Literature]
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2
[SID103604323]
[CID11504490]
Kd 1e-05Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR based single concentration kinetic assay [AID414359, Type: Literature]
View
3
[SID124962416]
[CID9874175]
Ki 1e-05Displacement of [3H]-N-methyl-scopolamine from human muscarinic M3 receptor after 6 hrs by cell based assay [AID578407, Type: Literature]
View
4
[SID160667544]
[CID11431874]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
5
[SID160667545]
[CID70681419]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
6
[SID160688684]
[CID11271303]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
7
[SID160688900]
[CID11191775]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
8
[SID160694182]
[CID70691874]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
9
[SID160694389]
[CID11431873]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
10
[SID160699512]
[CID11272761]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
11
[SID160699513]
[CID70693915]
Kd 1e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
12
[SID103680099]
[CID45266399]
Kd 1.26e-05Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362480, Type: Literature]
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13
[SID103693926]
[CID45273660]
Kd 2e-05Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetlcholine EC50 in presence and absence of compound by FLIPR assay [AID430439, Type: Literature]
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14
[SID103680181]
[CID25034183]
Kd 2.51e-05Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay [AID362480, Type: Literature]
View
15
[SID160667543]
[CID11442668]
Kd 2.51e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
16
[SID103632847]
[CID11533794]
Kd 2.51e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
View
17
[SID103613531]
[CID11528123]
Kd 3.16e-05Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR based single concentration kinetic assay [AID414359, Type: Literature]
View
18
[SID103632654]
[CID11519069]
Kd 3.16e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
View
19
[SID103604323]
[CID11504490]
Ki 3.16e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay [AID390994, Type: Literature]
View
20
[SID136939788]
[CID57400421]
IC50 3.16e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
21
[SID136944597]
[CID57403021]
IC50 3.16e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
22
[SID136921634]
[CID57390664]
IC50 3.16e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
23
[SID103564544]
[CID15057855]
Ki 3.4e-05Displacement of [3H]-N-methyl-scopolamine from human muscarinic M3 receptor after 6 hrs by cell based assay [AID578407, Type: Literature]
View
24
[SID103632846]
[CID42626089]
Kd 3.98e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
View
25
[SID103632914]
[CID42626093]
Kd 3.98e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
View
26
[SID103632776]
[CID11585116]
Kd 3.98e-05Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay [AID414945, Type: Literature]
View
27
[SID136941397]
[CID57401272]
IC50 3.98e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
28
[SID136939791]
[CID57400424]
IC50 3.98e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
29
[SID160688685]
[CID70689728]
Kd 3.98e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
30
[SID136924140]
[CID16065402]
Ki 4.9e-05Antagonist activity at human recombinant M3 receptor expressed in CHO-K1 cells assessed as inhibition of carbamoyl choline-induced calcium currents after 4 hrs by fluorimetry [AID627014, Type: Literature]
View
31
[SID103475844]
[CID10109130]
Ki 5e-05Binding affinity to human muscarinic M3 receptor [AID258308, Type: Literature]
View
32
[SID103564544]
[CID15057855]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
33
[SID103564544]
[CID15057855]
IC50 5.01e-05Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay [AID539979, Type: Literature]
View
34
[SID136925146]
[CID57392578]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
35
[SID136923587]
[CID57391774]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
36
[SID136929983]
[CID57395222]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
37
[SID160699727]
[CID11166540]
Kd 5.01e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
38
[SID136946243]
[CID57403966]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
39
[SID160678187]
[CID11190235]
Kd 5.01e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
40
[SID160678199]
[CID11442668]
Kd 5.01e-05Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control [AID658772, Type: Literature]
View
41
[SID136937966]
[CID57399404]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
42
[SID103688430]
[CID11519741]
IC50 5.01e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
43
[SID103564544]
[CID15057855]
Ki 5.1e-05Antagonist activity at human recombinant M3 receptor expressed in CHO-K1 cells assessed as inhibition of carbamoyl choline-induced calcium currents after 4 hrs by fluorimetry [AID627014, Type: Literature]
View
44
[SID103632654]
[CID11519069]
Ki 6e-05Displacement of [3H]N-methyl scopalamine from human cloned muscarinic M3 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay [AID414944, Type: Literature]
View
45
[SID103693926]
[CID45273660]
Ki 6e-05Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay [AID600365, Type: Literature]
View
46
[SID103693926]
[CID45273660]
Ki 6.31e-05Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M3 receptor expressed in CHO cell membrane [AID430441, Type: Literature]
View
47
[SID103685036]
[CID45269338]
Kd 6.31e-05Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetlcholine EC50 in presence and absence of compound by FLIPR assay [AID430439, Type: Literature]
View
48
[SID136941398]
[CID57401273]
IC50 6.31e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
49
[SID136931612]
[CID57396059]
IC50 6.31e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View
50
[SID136928158]
[CID57394170]
IC50 6.31e-05Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs [AID631741, Type: Literature]
View