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signal transducer and activator of transcript.. [gi:21618340] - Target BioActivity Data
Also known as: signal transducer and activator of transcription 3 isoform 1 [Homo sapiens].
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BioActivity Outcomes:
Active(309)
 
 
BioAssay Types:
Literature(256)
 
 
Screening(37)
 
 
Confirmatory(1)
 
 
BioActivity Types:
IC50(133)
 
 
Ki(8)
 
 
EC50(6)
 
 
Substance Types:
Chemical(309)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 120    Data Row: 309   Total Pages: 16   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID104247312]
[CID16659841]
IC50 0.023Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting [AID553167, Type: Literature]
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2
[SID104247312]
[CID16659841]
IC50 0.08Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting [AID553300, Type: Literature]
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3
[SID103535215]
[CID44432287]
IC50 0.108Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 mins [AID299414, Type: Literature]
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4
[SID103604242]
[CID24905708]
EC50 0.13Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis [AID339774, Type: Literature]
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5
[SID103632412]
[CID44582628]
IC50 0.15Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) by (EMSA) electrophoretic mobility shift assay [AID255033, Type: Literature]
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6
[SID103604166]
[CID24905707]
EC50 0.17Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis [AID339774, Type: Literature]
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7
[SID103613656]
[CID25218827]
Ki 0.19Displacement of fluorescent tagged beta-(Ala)-beta-(Ala)-G-pYLPQTV from human recombinant STAT3 by fluorescence polarization assay [AID419007, Type: Literature]
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8
[SID103604243]
[CID24905706]
EC50 0.2Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis [AID339774, Type: Literature]
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9
[SID103516894]
[CID4477]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: confirmatory]
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10
[SID103470993]
[CID44404162]
IC50 0.265Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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11
[SID103472101]
[CID44404807]
IC50 0.276Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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12
[SID103632412]
[CID44582628]
IC50 0.29Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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13
[SID174510323]
[CID73352819]
IC50 0.3Binding affinity to His-tagged STAT3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as inhibition of protein dimerization by fluorescence polarization assay [AID763571, Type: Literature]
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14
[SID103613654]
[CID25218825]
Ki 0.35Displacement of fluorescent tagged beta-(Ala)-beta-(Ala)-G-pYLPQTV from human recombinant STAT3 by fluorescence polarization assay [AID419007, Type: Literature]
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15
[SID103471027]
[CID11721811]
IC50 0.409Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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16
[SID103470992]
[CID44404161]
IC50 0.484Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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17
[SID103472099]
[CID44404805]
IC50 0.497Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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18
[SID103471028]
[CID11578573]
IC50 0.596Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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19
[SID103472096]
[CID44404803]
IC50 0.6Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) by (EMSA) electrophoretic mobility shift assay [AID255033, Type: Literature]
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20
[SID103472113]
[CID44404818]
IC50 0.717Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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