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signal transducer and activator of transcript.. [gi:21618340] - Target BioActivity Data
Also known as: signal transducer and activator of transcription 3 isoform 1 [Homo sapiens].
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BioActivity Outcomes:
Active(220)
 
 
BioAssay Types:
Literature(167)
 
 
Screening(37)
 
 
BioActivity Types:
IC50(59)
 
 
EC50(6)
 
 
Ki(5)
 
 
Substance Types:
Chemical(220)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 106    Data Row: 220   Total Pages: 5   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID104247312]
[CID16659841]
IC50 0.023Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting [AID553167, Type: Literature]
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2
[SID104247312]
[CID16659841]
IC50 0.08Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting [AID553300, Type: Literature]
View
3
[SID103535215]
[CID44432287]
IC50 0.108Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 mins [AID299414, Type: Literature]
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4
[SID103604242]
[CID24905708]
EC50 0.13Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis [AID339774, Type: Literature]
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5
[SID103632412]
[CID44582628]
IC50 0.15Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) by (EMSA) electrophoretic mobility shift assay [AID255033, Type: Literature]
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6
[SID103604166]
[CID24905707]
EC50 0.17Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis [AID339774, Type: Literature]
View
7
[SID103613656]
[CID25218827]
Ki 0.19Displacement of fluorescent tagged beta-(Ala)-beta-(Ala)-G-pYLPQTV from human recombinant STAT3 by fluorescence polarization assay [AID419007, Type: Literature]
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8
[SID103604243]
[CID24905706]
EC50 0.2Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis [AID339774, Type: Literature]
View
9
[SID103516894]
[CID4477]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: other]
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10
[SID103470993]
[CID44404162]
IC50 0.265Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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11
[SID103472101]
[CID44404807]
IC50 0.276Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
12
[SID103632412]
[CID44582628]
IC50 0.29Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
13
[SID103613654]
[CID25218825]
Ki 0.35Displacement of fluorescent tagged beta-(Ala)-beta-(Ala)-G-pYLPQTV from human recombinant STAT3 by fluorescence polarization assay [AID419007, Type: Literature]
View
14
[SID103471027]
[CID11721811]
IC50 0.409Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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15
[SID103470992]
[CID44404161]
IC50 0.484Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
16
[SID103472099]
[CID44404805]
IC50 0.497Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
17
[SID103471028]
[CID11578573]
IC50 0.596Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
18
[SID103472096]
[CID44404803]
IC50 0.6Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) by (EMSA) electrophoretic mobility shift assay [AID255033, Type: Literature]
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19
[SID103472113]
[CID44404818]
IC50 0.717Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
20
[SID103472096]
[CID44404803]
IC50 0.739Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
21
[SID103471030]
[CID11541933]
IC50 0.748Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
22
[SID103472100]
[CID44404806]
IC50 0.75Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
23
[SID103471029]
[CID11505920]
IC50 0.801Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
24
[SID103472098]
[CID44404804]
IC50 0.814Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
25
[SID103472097]
[CID24768129]
IC50 0.856Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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26
[SID103471026]
[CID11527533]
IC50 0.882Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
27
[SID103472112]
[CID44404817]
IC50 0.91Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
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28
[SID103472097]
[CID24768129]
IC50 1Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) by (EMSA) electrophoretic mobility shift assay [AID255033, Type: Literature]
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29
[SID103472110]
[CID44404815]
IC50 1.07Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
30
[SID103471036]
[CID11700543]
IC50 1.22Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
31
[SID103470995]
[CID44404164]
IC50 1.24Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
32
[SID103471024]
[CID11505560]
IC50 1.4Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
33
[SID103472109]
[CID44404814]
IC50 1.54Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
34
[SID164146570]
[CID71653594]
IC50 1.6Inhibition of STAT3 in IL-6-stimulated human HepG2 cells treated for 1 hr prior to IL-6 challenge measured after 5.5 hrs by luciferase reporter gene assay [AID736048, Type: Literature]
View
35
[SID103470994]
[CID44404163]
IC50 1.66Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
36
[SID103471025]
[CID11693012]
IC50 1.69Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
37
[SID103471011]
[CID11614102]
IC50 1.78Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
38
[SID103471031]
[CID11520319]
IC50 1.85Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
39
[SID103470991]
[CID44404160]
IC50 1.87Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
40
[SID103472111]
[CID44404816]
IC50 1.89Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
41
[SID103471034]
[CID11607224]
IC50 2.11Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
42
[SID103471015]
[CID11556346]
IC50 3.02Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
43
[SID103613655]
[CID25218826]
Ki 3.13Displacement of fluorescent tagged beta-(Ala)-beta-(Ala)-G-pYLPQTV from human recombinant STAT3 by fluorescence polarization assay [AID419007, Type: Literature]
View
44
[SID164143856]
[CID4655679]
IC50 3.567Inhibition of STAT3 in IL-6-stimulated human HepG2 cells treated for 1 hr prior to IL-6 challenge measured after 5.5 hrs by luciferase reporter gene assay [AID736048, Type: Literature]
View
45
[SID103471032]
[CID11686242]
IC50 4.22Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
46
[SID103604164]
[CID44568723]
EC50 4.6Inhibition of STAT3 Y705 phosphorylation in human U266 cells by western blot analysis [AID339774, Type: Literature]
View
47
[SID160672869]
[CID57384017]
IC50 6.3Inhibition of IFNgamma-induced STAT3 activation in human HeLa cells expressing p4xM67-tk-Luc treated 30 mins before TNFalpha challenge measured after 6 hrs [AID660829, Type: Literature]
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48
[SID103471035]
[CID11657710]
IC50 7Inhibitory concentration against signal transducer and activator of transcription 3 (stat3) using 5-carboxyfluoresceinyl-Ala-Tyr(PO3H2)-Leu-Pro-Gln-Thr-Val-NH2 by FP assay [AID255085, Type: Literature]
View
49
[SID103535349]
[CID23655830]
Ki 7.3Binding affinity to recombinant STAT3 by fluorescence polarization based binding assay [AID299450, Type: Literature]
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50
[SID103535210]
[CID44432281]
IC50 9Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 mins [AID299414, Type: Literature]
View