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serine/threonine-protein kinase PLK1 [Homo sa.. [gi:21359873] - Target BioActivity Data
Also known as: serine/threonine-protein kinase PLK1 [Homo sapiens].
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BioActivity Outcomes:
Active(11091)
 
 
BioAssay Types:
Confirmatory(10304)
 
 
Screening(689)
 
 
Literature(96)
 
 
BioActivity Types:
Potency(10204)
 
 
IC50(128)
 
 
EC50(30)
 
 
Kd(15)
 
 
Ki(3)
 
 
Substance Types:
Chemical(11091)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 34    Data Row: 11091   Total Pages: 222   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID136925373]
[CID15983966]
Kd 9.4e-05Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
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2
[SID103624610]
[CID11364421]
Kd 0.00019Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
3
[SID103508344]
[CID11957417]
IC50 0.0008Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
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4
[SID103624610]
[CID11364421]
IC50 0.00083Competitive inhibition of human PLK1 in presence of ATP [AID718976, Type: Literature]
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5
[SID104249696]
[CID10461508]
IC50 0.00087Competitive inhibition of human PLK1 in presence of ATP [AID718976, Type: Literature]
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6
[SID103612637]
[CID25263118]
IC50 0.001Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
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7
[SID134453399]
[CID25263120]
IC50 0.001Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
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8
[SID123089933]
[CID16050925]
IC50 0.002Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
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9
[SID134437919]
[CID16051023]
IC50 0.002Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
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10
[SID103610848]
[CID9826308]
IC50 0.002Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
11
[SID103610915]
[CID25263092]
IC50 0.002Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
12
[SID103612791]
[CID25263119]
IC50 0.003Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
13
[SID136932653]
[CID25263125]
IC50 0.003Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
14
[SID136936063]
[CID16050921]
IC50 0.003Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
15
[SID136922934]
[CID57391401]
IC50 0.003Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
16
[SID136939238]
[CID25263126]
IC50 0.004Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
17
[SID136932652]
[CID25263121]
IC50 0.004Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
18
[SID134457209]
[CID25263124]
IC50 0.006Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
19
[SID134437918]
[CID25263123]
IC50 0.007Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
20
[SID103583785]
[CID16038120]
Kd 0.02Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
21
[SID47213165]
[CID6484787]
DR IC50 uM 0.022Concentration Response fluorescence polarization-based assay to test purchased Analogs of Selected Hits from the Polo box domain (PBD) of Plk1 Primary HTS. [AID1083, Type: confirmatory]
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22
[SID103612574]
[CID25263117]
IC50 0.03Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichoplusia ni cells by scintillation proximity assay [AID418643, Type: Literature]
View
23
[SID103629211]
[CID25182616]
Kd 0.047Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
24
[SID103625298]
[CID24971423]
IC50 0.051Inhibition of human Plk1 [AID387787, Type: Literature]
View
25
[SID103681971]
[CID11661872]
EC50 0.08Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrs [AID433285, Type: Literature]
View
26
[SID134437214]
[CID56659846]
Kd 0.093Binding affinity to human polo-box domain of PLK1 after 1 hr by fluorescence polarization-based assay [AID609606, Type: Literature]
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27
[SID103625297]
[CID24941248]
IC50 0.099Inhibition of human Plk1 [AID387787, Type: Literature]
View
28
[SID103625162]
[CID24971415]
IC50 0.121Inhibition of human Plk1 [AID387787, Type: Literature]
View
29
[SID134449640]
[CID25126798]
Kd 0.13Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
30
[SID51089839]
[CID74787]
Potency 0.1683qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
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31
[SID103243222]
[CID44299148]
Kd 0.19Binding constant for PLK1 kinase domain [AID435934, Type: Literature]
View
32
[SID103243222]
[CID44299148]
Kd 0.19Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
33
[SID103694271]
[CID11495629]
EC50 0.21Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrs [AID433285, Type: Literature]
View
34
[SID47213067]
[CID3164070]
DR IC50 uM 0.21Concentration Response fluorescence polarization-based assay to test purchased Analogs of Selected Hits from the Polo box domain (PBD) of Plk1 Primary HTS. [AID1083, Type: confirmatory]
View
35
[SID103625296]
[CID24971422]
IC50 0.214Inhibition of human Plk1 [AID387787, Type: Literature]
View
36
[SID164133368]
[CID71717270]
Kd 0.22Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
37
[SID17407044]
[CID5086667]
DR_IC50uM_Run1 0.22Fluorescence Polarization assay for Plk1: IC50 Dose Response Assay [AID785, Type: confirmatory]
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38
[SID57264557]
[CID1730]
Potency 0.2378qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
View
39
[SID134441146]
[CID56663316]
Kd 0.256Binding affinity to human polo-box domain of PLK1 after 1 hr by fluorescence polarization-based assay [AID609606, Type: Literature]
View
40
[SID47195529]
[CID816729]
Potency 0.2668qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
View
41
[SID24791575]
[CID1319707]
Potency 0.2668qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
View
42
[SID123089189]
[CID16722836]
Kd 0.28Binding constant for PLK1 kinase domain [AID624975, Type: Literature]
View
43
[SID47213026]
[CID6460976]
DR IC50 uM 0.282Concentration Response fluorescence polarization-based assay to test purchased Analogs of Selected Hits from the Polo box domain (PBD) of Plk1 Primary HTS. [AID1083, Type: confirmatory]
View
44
[SID47213156]
[CID322478]
DR IC50 uM 0.295Concentration Response fluorescence polarization-based assay to test purchased Analogs of Selected Hits from the Polo box domain (PBD) of Plk1 Primary HTS. [AID1083, Type: confirmatory]
View
45
[SID848038]
[CID650462]
Potency 0.2993qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
View
46
[SID17412566]
[CID1494229]
Potency 0.2993qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]
View
47
[SID103685379]
[CID45269486]
EC50 0.31Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrs [AID433285, Type: Literature]
View
48
[SID47213115]
[CID3164062]
DR IC50 uM 0.325Concentration Response fluorescence polarization-based assay to test purchased Analogs of Selected Hits from the Polo box domain (PBD) of Plk1 Primary HTS. [AID1083, Type: confirmatory]
View
49
[SID134460321]
[CID56680338]
Kd 0.326Binding affinity to human polo-box domain of PLK1 after 1 hr by fluorescence polarization-based assay [AID609606, Type: Literature]
View
50
[SID103625232]
[CID24971419]
IC50 0.33Inhibition of human Plk1 [AID387787, Type: Literature]
View