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Interleukin-8; IL-8; C-X-C motif chemokine 8;.. [gi:124359] - Target BioActivity Data
Also known as: Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor; MDNCF-a; GCP/IL-8 protein IV; IL8/NAP1 form I; Interleukin-8; (Ala-IL-8)77; GCP/IL-8 protein II; IL-8(1-77); IL8/NAP1 form II; MDNCF-b; IL-8(5-77); IL-8(6-77); (Ser-IL-8)72; GCP/IL-8 protein I; IL8/NAP1 form III; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF-c; Neutrophil-activating factor; NAF; IL-8(7-77); GCP/IL-8 protein V; IL8/NAP1 form IV; IL-8(8-77); GCP/IL-8 protein VI; IL8/NAP1 form V; IL-8(9-77); GCP/IL-8 protein III; IL8/NAP1 form VI.
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BioActivity Outcomes:
Active(228)
 
 
BioAssay Types:
Confirmatory(209)
 
 
Literature(19)
 
 
BioActivity Types:
IC50(187)
 
 
Potency(41)
 
 
Substance Types:
Chemical(228)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 228   Total Pages: 5   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103191369]
[CID3033]
IC50 0.008Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
2
[SID103568331]
[CID18546352]
IC50 0.009Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
3
[SID103686313]
[CID45269905]
IC50 0.01Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
4
[SID103684529]
[CID45269050]
IC50 0.012Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
5
[SID103686293]
[CID45269894]
IC50 0.013Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
6
[SID103198657]
[CID13409348]
IC50 0.013Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
7
[SID103460096]
[CID180540]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
8
[SID103688107]
[CID45270722]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
9
[SID103277835]
[CID14076674]
IC50 0.025Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
10
[SID103691580]
[CID45272452]
IC50 0.025Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
11
[SID17389096]
[CID6167]
Potency 0.0473qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]
View
12
[SID103459872]
[CID114864]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
13
[SID103163840]
[CID3715]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
14
[SID103686292]
[CID45269893]
IC50 0.05Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
15
[SID17389095]
[CID6167]
Potency 0.0531qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]
View
16
[SID103273527]
[CID5509]
IC50 0.09Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
17
[SID144089017]
[CID4714904]
IC50_CF-PAF_Mean 0.228SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_8, Type: confirmatory]
View
18
[SID121286198]
[CID51361444]
IC50_Mean 0.293Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
19
[SID99358358]
[CID303610]
IC50_Mean 0.338Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
20
[SID103277555]
[CID13752584]
IC50 0.4Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
21
[SID17388687]
[CID638015]
Potency 0.4216qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]
View
22
[SID17389450]
[CID6436079]
Potency 0.4216qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]
View
23
[SID103198639]
[CID15581854]
IC50 0.5Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
24
[SID103689766]
[CID14762946]
IC50 0.5Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
25
[SID144089019]
[CID3231682]
IC50_CF-PAF_Mean 0.522SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_8, Type: confirmatory]
View
26
[SID85248360]
[CID1088438]
IC50 0.5507SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]
View
27
[SID85176678]
[CID1088438]
IC50 0.596SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]
View
28
[SID103684514]
[CID45269044]
IC50 0.6Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
29
[SID24805492]
[CID5759184]
IC50_Mean 0.607Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
30
[SID85176678]
[CID1088438]
IC50_Mean 0.62SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]
View
31
[SID16953363]
[CID2064400]
IC50_Mean 0.628Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
32
[SID103686294]
[CID45269895]
IC50 0.65Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]
View
33
[SID49648026]
[CID930668]
IC50_Mean 0.684Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
34
[SID17414313]
[CID5737667]
IC50_Mean 0.685Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
35
[SID17412817]
[CID2864614]
IC50_Mean 0.697Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
36
[SID85248360]
[CID1088438]
IC50_Mean 0.81SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]
View
37
[SID121286187]
[CID51361435]
IC50_Mean 0.817Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
38
[SID24826667]
[CID2402478]
IC50_Mean 0.967Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
39
[SID26669546]
[CID3790826]
IC50_Mean 0.969Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
40
[SID49648026]
[CID930668]
IC50_Mean 0.987Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
41
[SID49669711]
[CID2872306]
IC50_Mean 1.01Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
42
[SID92764052]
[CID299926]
IC50_Mean 1.04Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
43
[SID22405172]
[CID4369759]
IC50_Mean 1.07Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
44
[SID17434078]
[CID1312703]
IC50_Mean 1.11Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
45
[SID99358358]
[CID303610]
IC50_Mean 1.12Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
46
[SID49669711]
[CID2872306]
IC50_Mean 1.12Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
47
[SID24817011]
[CID1487004]
IC50_Mean 1.19Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
48
[SID24817011]
[CID1487004]
IC50_Mean 1.25Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]
View
49
[SID24805492]
[CID5759184]
IC50_Mean 1.25Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]
View
50
[SID87544808]
[CID909915]
IC50 1.31SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]
View