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BioActivity Data for Compound phenylacetic acid (CID 999)

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BioActivity Outcomes:
Inactive(297)
 
 
Inconclusive(6)
 
 
Unspecified(13)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
NR LBD ER(14)
 
 
NR LBD AR(14)
 
 
NR LBD VDR(9)
 
 
NR LBD GR(8)
 
 
BioAssay Types:
Confirmatory(238)
 
 
 
Summary(48)
 
 
 
Literature(14)
 
 
 
Screening(7)
 
 
BioActivity Types:
Potency(207)
 
 
 
AC50(3)
 
 
IC50(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 224    Data Row: 316   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103280956]
IC50 96Inhibition of aldose reductase [AID309933, Type: Literature]
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2
[SID103280956]
IC50 500Antagonist activity at human T1R2/T1R3 receptor expressed in HEK293E cells assessed as inhibition of sucralose-induced intracellular calcium mobilization [AID439612, Type: Literature]
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3
[SID103280956]
Kd 50000Binding affinity against Lck SH2 domain [AID99714, Type: Literature]
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4
[SID103280956]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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5
[SID103280956]
Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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6
[SID103280956]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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7
[SID103280956]
Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3]H-hypoxanthine incorporation assay [AID477925, Type: Literature]
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8
[SID103280956]
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay [AID477926, Type: Literature]
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9
[SID103280956]
Partition coefficient, log P of the compound [AID310931, Type: Literature]
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10
[SID103280956]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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11
[SID103280956]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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12
[SID103280956]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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13
[SID103280956]
Activity at human recombinant PON1 assessed as hydrolysis of lactone ring at 1 mM by Ellman's method [AID342465, Type: Literature]Serum paraoxonase/arylesterase 1 [gi:308153572]
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14
[SID170465102]
Ac50 1.12202qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen 2, green channel [AID1117310, Type: confirmatory]
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15
[SID170465102]
Ac50 2.23872qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen2, ratio channel [AID1117312, Type: confirmatory]
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16
[SID170465102]
Ac50 7.94328qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen 2, blue channel [AID1117314, Type: confirmatory]
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17
[SID170465102]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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18
[SID170465102]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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19
[SID170465102]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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20
[SID170465102]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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