CHEMBL1627233 (CID 9982767) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Unspecified(3)
 
 
Top Targets:
p450(5)
 
 
 
NR LBD VDR(1)
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
IC50(5)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124969420]
IC50 0.0074Inhibition of human CYP24A1 expressed in chinese hamster V79 cells [AID492341, Type: Literature]1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [gi:19862747]
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2
[SID160686733]
IC50 0.0074Inhibition of human CYP24 hydroxylase expressed in V79 cells [AID282480, Type: Literature]1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [gi:19862747]
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3
[SID160686733]
IC50 0.554Inhibition of human CYP27B hydroxylase expressed in SW900 cells [AID282482, Type: Literature]25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [gi:3182968]
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4
[SID160686733]
ED50 1Effect on VDR-mediated transcriptional activity in CV1 cells transfected with human recombinant VDR [AID282483, Type: Literature]Vitamin D3 receptor [gi:137617]
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5
[SID160686733]
ED50 1Effect on VDR-mediated transcriptional activity in CV1 cells transfected with human recombinant VDR [AID282483, Type: Literature]Vitamin D3 receptor [gi:137617]
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6
[SID160686733]
ED50 1Effect on VDR-mediated transcriptional activity in CV1 cells transfected with human recombinant VDR [AID282483, Type: Literature]Vitamin D3 receptor [gi:137617]
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7
[SID160686733]
ED50 1Effect on VDR-mediated transcriptional activity in CV1 cells transfected with human recombinant VDR [AID282483, Type: Literature]Vitamin D3 receptor [gi:137617]
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8
[SID160686733]
IC50 1Inhibition of human CYP27A1 hydroxylase expressed in V79 cells [AID282481, Type: Literature]Sterol 26-hydroxylase, mitochondrial [gi:399288]
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9
[SID124969420]
IC50 1Inhibition of human CYP27A1 hydroxylase expressed in V79 cells [AID282481, Type: Literature]Sterol 26-hydroxylase, mitochondrial [gi:399288]
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