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BioActivity Data for Compound phenylpyruvic acid (CID 997)

BioActivity Outcomes:
Active(4)
 
 
Inactive(75)
 
 
Inconclusive(8)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
MFS(4)
 
 
 
NR LBD Fxr(4)
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
 
Summary(24)
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(80)
 
 
 
 
Ki(3)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 92    Data Row: 92   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144211679]
Potency-Replicate_1 10.9622qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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2
[SID144211679]
Potency-Replicate_1 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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3
[SID144211679]
Ratio Potency (uM) 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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4
[SID103762574]
Ki 28.8403Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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5
[SID103762574]
IC50 75.8578Inhibition of glycolic acid oxidase (unknown origin) assessed as enzyme-mediated reduction of NaDCIP by sodium glycolate after 1 to 3 mins by spectrophotometer analysis [AID1130306, Type: Literature]
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6
[SID103762574]
Ki 79Inhibition of mouse Oat1 expressed in Xenopus oocytes [AID598880, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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7
[SID103762574]
Ki 79.4328Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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8
[SID103762574]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681140, Type: Literature]Monocarboxylate transporter 4 [gi:6225705]
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9
[SID103762574]
Ratio of pKi for mouse Oat1 expressed in Xenopus oocytes to pKi for mouse Oat6 expressed in Xenopus oocytes [AID360151, Type: Literature]
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10
[SID144211679]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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11
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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12
[SID144211679]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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13
[SID144211679]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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14
[SID144211679]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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15
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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17
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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18
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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19
[SID144211679]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
20
[SID144211679]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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