Phenol (CID 996) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(40)
 
 
Inactive(247)
 
 
Inconclusive(16)
 
 
Unspecified(240)
 
 
Top Targets:
alpha CA I II..(17)
 
 
 
NR LBD PPAR(15)
 
 
 
7TM GPCR Srsx(12)
 
 
 
7TM GPCR Srx(12)
 
 
NR LBD TR(12)
 
 
BioAssay Types:
Confirmatory(200)
 
 
 
 
Literature(144)
 
 
 
 
 
Screening(31)
 
 
BioActivity Types:
Potency(164)
 
 
 
 
IC50(124)
 
 
 
 
Ki(50)
 
 
 
Kd(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 465    Data Row: 543   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176204]
Ki 2.7Inhibition of human carbonic anhydrase 3 after 15 mins by stopped flow CO2 hydration method [AID501905, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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2
[SID103176204]
Ki 2.7Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method [AID496915, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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3
[SID103176204]
Ki 2.7Inhibition of human CA3 by stopped-flow CO2 hydration assay [AID462272, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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4
[SID103176204]
Kd 3.8Agonist activity at GABAA assessed as enhancement of channel current [AID447577, Type: Literature]
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5
[SID103176204]
Ki 5.5Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method [AID496914, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID103176204]
Ki 5.5Inhibition of human CA2 by stopped-flow CO2 hydration assay [AID462271, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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7
[SID103176204]
Ki 5.5Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568363, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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8
[SID103176204]
Ki 5.5Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method [AID501904, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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9
[SID103176204]
Ki 5.5Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay [AID588187, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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10
[SID103176204]
Ki 8.8Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method [AID502077, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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11
[SID103176204]
Ki 8.8Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568364, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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12
[SID103176204]
Ki 8.8Inhibition of human CA9 by stopped-flow CO2 hydration assay [AID462278, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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13
[SID103176204]
Ki 8.8Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method [AID496921, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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14
[SID103176204]
Ki 9.2Inhibition of human CA12 by stopped-flow CO2 hydration assay [AID462279, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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15
[SID103176204]
Ki 9.2Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method [AID501912, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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16
[SID103176204]
Ki 9.2Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method [AID496922, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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17
[SID103176204]
Ki 9.2Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568365, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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18
[SID103176204]
Ki 9.5Inhibition of human carbonic anhydrase 4 after 15 mins by stopped flow CO2 hydration method [AID501906, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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19
[SID103176204]
Ki 9.5Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method [AID496916, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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20
[SID103176204]
Ki 9.5Inhibition of human CA4 by stopped-flow CO2 hydration assay [AID462273, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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21
[SID103176204]
Ki 10.1Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay [AID588186, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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22
[SID103176204]
Ki 10.2Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method [AID501903, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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23
[SID103176204]
Ki 10.2Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568362, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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24
[SID103176204]
Ki 10.2Inhibition of human CA1 by stopped-flow CO2 hydration assay [AID462270, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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25
[SID103176204]
Ki 10.2Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method [AID496913, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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26
[SID103176204]
Ki 10.5Inhibition of mouse carbonic anhydrase 15 after 15 mins by stopped flow CO2 hydration method [AID501915, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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27
[SID103176204]
Ki 10.5Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method [AID496925, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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28
[SID103176204]
Ki 10.5Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay [AID331293, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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29
[SID103176204]
Ki 11.5Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method [AID496924, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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30
[SID103176204]
Ki 11.5Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method [AID501914, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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31
[SID103176204]
Ki 11.5Inhibition of human CA14 by stopped-flow CO2 hydration assay [AID462281, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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32
[SID103176204]
Ki 13.7Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay [AID607497, Type: Literature]Carbonic anhydrase [gi:123910379]
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33
[SID103176204]
IC50 16.045Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay [AID303044, Type: Literature]
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34
[SID103176204]
IC50 16.535Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay [AID303043, Type: Literature]
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35
[SID103176204]
Ki 17.3Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID588184, Type: Literature]Hypothetical protein NCE103 [gi:74656605]
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36
[SID103176204]
Km 19Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) [AID39219, Type: Literature]
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37
[SID103176204]
Ki 25.9Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID588185, Type: Literature]
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38
[SID26753013]
Potency 1000qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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39
[SID26753013]
Potency 1000qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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40
[SID26753013]
Potency 1000qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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41
[SID26753013]
Potency 1000qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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42
[SID48415088]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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43
[SID46392435]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, T4 Lysozyme Mutant L99aM102Q BOUND BY PHENOL [gi:21466086]
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44
[SID103176204]
Ki 64Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID588183, Type: Literature]Beta-carbonic anhydrase 1 [gi:54042506]
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45
[SID103176204]
Ki 79Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID588182, Type: Literature]PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) (Sulfate tr [gi:81671928]
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46
[SID103176204]
Kd 90.9Dissociation constant against T4 lysozyme mutant L99A/M102Q [AID238123, Type: Literature]Lysozyme [gi:126605]
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47
[SID103176204]
IC50 100Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay [AID636075, Type: Literature]
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48
[SID103176204]
Ki 208Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method [AID496919, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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49
[SID103176204]
Ki 208Inhibition of human CA6 by stopped-flow CO2 hydration assay [AID462276, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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50
[SID103176204]
Ki 208Inhibition of human carbonic anhydrase 6 after 15 mins by stopped flow CO2 hydration method [AID501909, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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