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BioActivity Data for Compound Chir 99021 (CID 9956119)

BioActivity Outcomes:
Active(224)
 
 
Inactive(423)
 
 
Inconclusive(5)
 
 
Unspecified(579)
 
 
Top Targets:
STKc GSK3(6)
 
 
 
PKc like(3)
 
 
STKc JNK(3)
 
 
STKc ERK1 2 l..(2)
 
 
CYCLIN(2)
 
 
BioAssay Types:
Confirmatory(694)
 
 
 
 
 
Literature(217)
 
 
 
 
 
BioAssay Categories:
In vitro(672)
 
 
 
Biochemical(393)
 
 
 
 
Toxicity(1)
 
 
ADME(9)
 
 
 
Cell-based(678)
 
 
 
BioActivity Types:
IC50(673)
 
 
 
Potency(25)
 
 
 
 
AC50(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 792    Data Row: 1231   Total Pages: 62   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134216516]
AC50_uM 2.97e-06PathHunter bCatenin (U2-OS) Measured in Cell-Based System Using Plate Reader - 2133-06_Inhibitor_Dose_DryPowder_Activity [AID624088, Type: confirmatory]
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2
[SID134216516]
AC50_uM 0.002TCF/LEF Reporter Assay Measured in Cell-Based System Using Plate Reader - 2133-01_Inhibitor_Dose_DryPowder_Activity [AID624086, Type: confirmatory]
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3
[SID103566476]
IC50 0.007Inhibition of GSK3-beta [AID512484, Type: Literature]
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4
[SID103566476]
IC50 0.01Inhibition of GSK3alpha [AID512483, Type: Literature]
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5
[SID103566476]
IC50 0.03Inhibition of human recombinant GSK3-beta after 1 hr by KinaseGlo luciferase assay [AID641179, Type: Literature]Glycogen synthase kinase-3 beta [gi:20455502]
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6
[SID103566476]
IC50 0.03Inhibition of GSK3-beta [AID641178, Type: Literature]
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7
[SID103566476]
IC50 0.21416SANGER: Inhibition of human SW982 cell growth in a cell viability assay. [AID741919, Type: confirmatory]
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8
[SID103566476]
IC50 0.30672SANGER: Inhibition of human GCT cell growth in a cell viability assay. [AID742176, Type: confirmatory]
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9
[SID103566476]
IC50 0.58499SANGER: Inhibition of human 769-P cell growth in a cell viability assay. [AID741936, Type: confirmatory]
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10
[SID103566476]
IC50 0.58832SANGER: Inhibition of human LOXIMVI cell growth in a cell viability assay. [AID742321, Type: confirmatory]
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11
[SID137275880]
Potency 0.8333Immunotoxin (HA22) sensitization/mitigation study - treatment arm [AID1159512, Type: confirmatory]
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12
[SID103566476]
IC50 0.8462SANGER: Inhibition of human D-336MG cell growth in a cell viability assay. [AID742104, Type: confirmatory]
View
13
[SID134216516]
AC50_uM 0.86Human p-Tau and Total Tau ELISA Measured in Cell-Based System Using Plate Reader - 2133-07_Inhibitor_Dose_DryPowder_Activity [AID624057, Type: confirmatory]
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14
[SID103566476]
IC50 0.92131SANGER: Inhibition of human S-117 cell growth in a cell viability assay. [AID741841, Type: confirmatory]
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15
[SID137275880]
Potency 0.935Immunotoxin (HA22) sensitization/mitigation study [AID1159510, Type: confirmatory]
View
16
[SID103566476]
IC50 0.94852SANGER: Inhibition of human D-247MG cell growth in a cell viability assay. [AID742101, Type: confirmatory]
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17
[SID103566476]
IC50 1.07912SANGER: Inhibition of human TYK-nu cell growth in a cell viability assay. [AID742028, Type: confirmatory]
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18
[SID103566476]
IC50 1.30469SANGER: Inhibition of human A498 cell growth in a cell viability assay. [AID741953, Type: confirmatory]
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19
[SID103566476]
EC50 1.5Inhibition of GSK3-beta in human HepG2 cells assessed as incorporation of [3H]glucose into glycogen after 3 hrs by liquid scintillation counting [AID641180, Type: Literature]Glycogen synthase kinase-3 beta [gi:20455502]
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20
[SID103566476]
IC50 1.66898SANGER: Inhibition of human BCPAP cell growth in a cell viability assay. [AID741974, Type: confirmatory]
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