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Phenylalanine (CID 994) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(138)
 
 
Inconclusive(8)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
NR LBD PPAR(2)
 
 
BioAssay Types:
Confirmatory(107)
 
 
 
Literature(25)
 
 
 
Summary(15)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(61)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 170    Data Row: 172   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416422]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID103194122]
Km 740.5TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681145, Type: other]SLC16A10 protein [gi:121945115]
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3
[SID103194122]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681174, Type: other]Monocarboxylate transporter 8 [gi:81871342]
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4
[SID103194122]
Solubility assay expressed as [HbSdrug/HbS control] at 10 mM concentration [AID21129, Type: Literature]
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5
[SID103194122]
Solubility assay expressed as [HbSdrug/HbS control] at 20 mM concentration [AID21130, Type: Literature]
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6
[SID103194122]
Solubility assay expressed as [HbSdrug/HbS control] at 40 mM concentration [AID21131, Type: Literature]
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7
[SID103194122]
Solubility assay expressed as [HbSdrug/HbS control] at 5 mM concentration [AID21132, Type: Literature]
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8
[SID103194122]
Solubility of Deoxyhemoglobin S (dHbS) concentration after addition dithionite as control [AID21143, Type: Literature]
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9
[SID103194122]
Solubility of Haemoglobin S (HbS) concentration after addition of acid and dithionite [AID21145, Type: Literature]
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10
[SID103194122]
Solubility ratio ([HbS+drug (10 mM)]/[HbS-drug]) [AID22012, Type: Literature]
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11
[SID103194122]
Solubility ratio ([HbS+drug (20 mM)]/[HbS-drug] [AID22013, Type: Literature]
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12
[SID103194122]
Solubility ratio ([HbS+drug (40 mM)]/[HbS-drug]) [AID22148, Type: Literature]
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13
[SID103194122]
Solubility ratio ([HbS+drug (5 mM)]/[HbS-drug]) [AID22149, Type: Literature]
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14
[SID103194122]
Maximal activatory effect against human carbonic anhydrase II (hCA II) [AID47718, Type: Literature]
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15
[SID103194122]
Maximal activatory effect against human carbonic anhydrase I (hCA I) [AID50341, Type: Literature]
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16
[SID103194122]
Evaluated for antisickling activity, and initial HbS concentration was reported, values from different experiments (no. of runs=2) [AID85631, Type: Literature]
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17
[SID103194122]
Control value of dHbS(no. of runs=2) [AID85636, Type: Literature]
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18
[SID103194122]
Antigelling activity expressed as ratio of soluble sickle hemoglobin (HbS) of compound (g/dL) and that of control at 10 mM concentration. [AID91208, Type: Literature]
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19
[SID103194122]
Antigelling activity expressed as ratio of soluble sickle hemoglobin (HbS) of compound (g/dL) and that of control at 20 mM concentration. [AID91210, Type: Literature]
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20
[SID103194122]
Antigelling activity expressed as ratio of soluble sickle hemoglobin (HbS) of compound (g/dL) and that of control at 40 mM concentration [AID91211, Type: Literature]
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21
[SID103194122]
Antigelling activity expressed as ratio of soluble sickle hemoglobin (HbS) of compound (g/dL) and that of control at 5 mM concentration [AID91213, Type: Literature]
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22
[SID103194122]
Compound was evaluated for antisickling activity , and ratio was calculated as solubility HbS compound (g/dL) / solubility HbS control(g/dL) at a concentration of 40 mM (for 173 assays) [AID231855, Type: Literature]
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23
[SID103194122]
Evaluated for antisickling activity, and ratio was calculated as solubility HbS (g/dL) / solubility HbS control(g/dL) at a concentration of 10 mM [AID231856, Type: Literature]
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24
[SID103194122]
Evaluated for antisickling activity, and ratio was calculated as solubility HbS (g/dL) / solubility HbS control(g/dL) at a concentration of 20 mM [AID231857, Type: Literature]
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25
[SID103194122]
Evaluated for antisickling activity, and ratio was calculated as solubility HbS (g/dL) / solubility HbS control(g/dL) at a concentration of 5 mM [AID231858, Type: Literature]
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26
[SID103194122]
Evaluated for antisickling activity, and ratio was calculated as solubility HbS compound (g/dL) / solubility HbS control(g/dL) at a concentration of 40 mM [AID231859, Type: Literature]
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27
[SID144203562]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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28
[SID144203562]
Potency-Replicate_1 29.8493qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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29
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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30
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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31
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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32
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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33
[SID144203562]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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34
[SID144203562]
ATAD5 Potency (uM) qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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35
[SID144203562]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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36
[SID144203562]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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37
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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38
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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39
[SID144203562]
ER Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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40
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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41
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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42
[SID144203562]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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43
[SID144203562]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
44
[SID144203562]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
45
[SID144203562]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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46
[SID144203562]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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47
[SID144203562]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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48
[SID144203562]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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49
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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50
[SID144203562]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View