Bookmark and Share
GW0742 (CID 9934458) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(46)
 
 
Inactive(141)
 
 
Inconclusive(83)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD PPAR(35)
 
 
 
 
 
NR LBD TR(11)
 
 
 
 
NR LBD VDR(11)
 
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(9)
 
 
 
BioAssay Types:
Confirmatory(199)
 
 
 
 
Literature(31)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(12)
 
 
 
BioActivity Types:
Potency(215)
 
 
 
 
EC50(11)
 
 
 
 
Kd(3)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 238    Data Row: 275   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103215363]
Kd 0.0004Binding affinity to human PPARdelta (unknown origin) by competitive TR-FRET assay [AID731520, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
2
[SID103215363]
EC50 0.001Maximum transcriptional activation of human PPAR delta receptor [AID156617, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
3
[SID103215363]
IC50 0.001Binding affinity for human PPAR delta receptor [AID156625, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
4
[SID144212728]
Ratio Potency (uM) 0.001qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
View
5
[SID103215363]
EC50 0.0029Displacement of pan-PPAR fluormone from PPARdelta LBD by TR-FRET based LanthaScreen assay [AID675855, Type: Literature]
View
6
[SID103215363]
EC50 0.03Activity against murine PPAR delta receptor [AID156784, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
7
[SID103215363]
EC50 0.3Agonist activity at human PPARdelta LBD by cell based luciferase reporter gene assay [AID569828, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
8
[SID103215363]
EC50 0.92Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay [AID675854, Type: Literature]
View
9
[SID103215363]
EC50 1.1Maximum transcriptional activation of human PPAR alpha receptor [AID156147, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
10
[SID144212728]
Ratio Potency (uM) 1.1391qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
11
[SID26753244]
Potency 1.9953qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
12
[SID103215363]
EC50 2Maximum transcriptional activation of human PPAR gamma receptor [AID156945, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
13
[SID26753243]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
14
[SID103215363]
EC50 8.8Activity against murine PPAR alpha receptor [AID156452, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
15
[SID26753243]
Potency 10qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
View
16
[SID144212728]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
View
17
[SID144212728]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
View
18
[SID29215130]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
19
[SID144212728]
Potency-Replicate_1 21.6899qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
20
[SID144212728]
Potency-Replicate_1 21.8724qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
View
21
[SID144212728]
Potency-Replicate_1 21.8724qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
View
22
[SID144212728]
Potency-Replicate_1 21.8724qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
View
23
[SID144212728]
Potency-Replicate_1 24.5412qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
View
24
[SID29215130]
Potency 25.1189qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay [AID602200, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
25
[SID29215130]
Potency 31.6228qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
View
26
[SID144212728]
Potency-Replicate_1 34.3762qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
27
[SID26753244]
Potency-Replicate_1 44.6684qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
View
28
[SID144212728]
Potency-Replicate_1 48.5577qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
View
29
[SID144212728]
Potency-Replicate_1 48.9662qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
View
30
[SID26753244]
Potency 50.1187qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
View
31
[SID144212728]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
32
[SID144212728]
Potency-Replicate_1 54.941qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
View
33
[SID144212728]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
34
[SID26753244]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
35
[SID144212728]
Potency-Replicate_1 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
View
36
[SID144212728]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
View
37
[SID103215363]
Antiatherogenic effect in HC/HF diet-fed apolipoprotein E-deficient C57BL/6J mouse assessed as increase in HDL-cholesterol at 2 mg/kg/day for 4 weeks [AID547907, Type: Literature]
View
38
[SID103215363]
Drug level in LDLR-deficient mouse serum at 60 mg/kg [AID547923, Type: Literature]
View
39
[SID103215363]
Transactivation of PPARdelta (unknown origin) expressed in HEK293 cells co-transfected with PDK4-PPRE by luciferase reporter gene assay [AID730945, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
40
[SID103215363]
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of TFAM gene expression after 4 days by real time PCR analysis [AID730941, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
41
[SID103215363]
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of NRF1 gene expression after 4 days by real time PCR analysis [AID730942, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
42
[SID103215363]
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of COX4-2 gene expression after 4 days by real time PCR analysis [AID730943, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
43
[SID103215363]
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of COX4-1 gene expression after 4 days by real time PCR analysis [AID730944, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
44
[SID103215363]
Agonist activity at mouse PPAR-alpha expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay [AID547902, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
45
[SID103215363]
Agonist activity at mouse PPAR-gammaexpressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay [AID547904, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
46
[SID85787647]
SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]myc proto-oncogene protein [Homo sapiens] [gi:71774083]
View
47
[SID103215363]
EC50 0.0058Agonist activity at mouse PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay [AID547903, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
48
[SID103215363]
EC50 10Activity against murine PPAR gamma receptor [AID157278, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
49
[SID103215363]
Toxicity in LDLR-deficient mouse assessed as increase in liver weight at 60 mg/kg [AID547924, Type: Literature]
View
50
[SID103215363]
Octanol-water partition coefficient, log P of the compound [AID675856, Type: Literature]
View