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BioActivity Data for Compound alvocidib (CID 9910986)

BioActivity Outcomes:
Active(40)
 
 
Inactive(49)
 
 
Inconclusive(39)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
 
NR LBD Fxr(4)
 
 
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(87)
 
 
 
 
Summary(26)
 
 
 
 
Screening(15)
 
 
 
BioAssay Categories:
Toxicity(6)
 
 
 
Cell-based(21)
 
 
 
BioActivity Types:
Potency(96)
 
 
 
 
IC50(8)
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 128    Data Row: 128   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170466414]
IC50 0.0212Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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2
[SID144206947]
Potency 0.0282qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID144206947]
Potency 0.0794qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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4
[SID170466414]
IC50 0.0807Increased chromatin condensation in HeLa cells-IC50 [AID1117350, Type: confirmatory]
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5
[SID144206947]
Potency 0.0944qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID144206947]
Potency-Replicate_1 0.1059qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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7
[SID144206947]
Potency-Replicate_1 0.1059qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID170466414]
IC50 0.1138VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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9
[SID144206947]
AR Potency (uM) 0.114358qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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10
[SID144206947]
Potency-Replicate_1 0.1496qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID144206947]
Potency-Replicate_1 0.1496qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID144206947]
Potency-Replicate_1 0.1496qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID170466414]
IC50 0.1905nuclear beta catenin stimulation in WNT3A conditioned C2C12 cells-IC50 [AID1117325, Type: confirmatory]
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14
[SID144206947]
Potency-Replicate_1 0.2113qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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15
[SID144206947]
Potency-Replicate_1 0.2113qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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16
[SID144206947]
Ratio Potency (uM) 0.221476qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID170466414]
Potency-Replicate_1 0.2371qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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18
[SID170466414]
Potency-Replicate_1 0.2985qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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19
[SID144206947]
Potency 0.3162qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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20
[SID170466414]
IC50 0.32837VEGF stimulated ADSC/ECFC co-culture nuclear area decrease (viability)-IC50 [AID1117324, Type: confirmatory]
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