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GW 4064 (CID 9893571) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(34)
 
 
Inconclusive(8)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD Fxr(41)
 
 
 
 
HELICc(3)
 
 
ABCC MRP doma..(2)
 
 
RIP(2)
 
 
Menin(2)
 
 
 
BioAssay Types:
Literature(61)
 
 
 
 
 
Confirmatory(41)
 
 
 
 
Screening(14)
 
 
 
BioActivity Types:
Potency(43)
 
 
 
 
EC50(26)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 113    Data Row: 117   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103317356]
EC50 0.015Agonist activity at FXR [AID694036, Type: Literature]
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2
[SID103317356]
EC50 0.015Ligand dependent recruitment of SRC1(676-700) peptide to human Farnesoid X-activated receptor by fluorescence resonance energy transfer assay [AID72529, Type: Literature]Bile acid receptor [gi:46577705]
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3
[SID103317356]
EC50 0.02Agonist activity at human GST-fused FXR LBD assessed as cofactor peptide interaction with receptor ligand binding domain by FRET assay [AID494859, Type: Literature]Bile acid receptor [gi:46577705]
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4
[SID103317356]
EC50 0.03Agonist activity at human full length FXR transfected in HEK293 cells coexpressing pTRexDest/pGL2promotor assessed as luciferase activity by direct reporter cellular assay [AID494863, Type: Literature]Bile acid receptor [gi:46577705]
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5
[SID103317356]
EC50 0.035Agonist activity at human GST-fused FXR LBD expressed in HEK293 cells coexpressing GAL4-DNA bindig domain and pFRluc by mammalian one-hybrid assay [AID494861, Type: Literature]Bile acid receptor [gi:46577705]
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6
[SID103317356]
EC50 0.037Effective concentration against Farnesoid X receptor (FXR) [AID72526, Type: Literature]Bile acid receptor [gi:46577705]
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7
[SID103317356]
EC50 0.045Agonist activity at human FXR assessed as recruitment of SRC1 peptide by TR-FRET assay [AID755462, Type: Literature]Bile acid receptor [gi:46577705]
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8
[SID103317356]
EC50 0.059Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assay [AID433264, Type: Literature]Bile acid receptor [gi:46577705]
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9
[SID103317356]
EC50 0.059Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assay [AID352768, Type: Literature]Bile acid receptor [gi:46577705]
View
10
[SID103317356]
EC50 0.059Agonist activity at human amino-terminal polyhistidine-tagged FXR alpha LBD (amino acids 237 to 472) assessed as cofactor peptide SRC-1 interaction with receptor ligand binding domain after 2 hrs by FRET assay [AID622453, Type: Literature]Bile acid receptor [gi:46577705]
View
11
[SID103317356]
EC50 0.059Agonist activity at human FXR LBD assessed as SRC1 peptide recruitment by FRET assay [AID577551, Type: Literature]Bile acid receptor [gi:46577705]
View
12
[SID103317356]
EC50 0.059Agonist activity at FXR assessed as receptor-SRC-1 peptide interaction by FRET assay [AID341960, Type: Literature]
View
13
[SID103317356]
IC50 0.064Displacement of radioligand from human FXR by scintillation proximity assay [AID352177, Type: Literature]Bile acid receptor [gi:46577705]
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14
[SID103317356]
EC50 0.065Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay [AID341962, Type: Literature]
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15
[SID103317356]
EC50 0.065Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression [AID577553, Type: Literature]Bile acid receptor [gi:46577705]
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16
[SID103317356]
EC50 0.065Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay [AID622454, Type: Literature]Bile acid receptor [gi:46577705]
View
17
[SID103317356]
EC50 0.065Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assay [AID352765, Type: Literature]Bile acid receptor [gi:46577705]
View
18
[SID103317356]
EC50 0.065Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cells [AID433266, Type: Literature]Bile acid receptor [gi:46577705]
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19
[SID103317356]
EC50 0.07Activation of human farnesoid X receptor [AID240068, Type: Literature]Bile acid receptor [gi:46577705]
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20
[SID103317356]
EC50 0.07Agonistic activity at FXR in HEK293 cells by GAL4 transactivation activity [AID294203, Type: Literature]Bile acid receptor [gi:46577705]
View