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Cyproterone Acetate (CID 9880) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(92)
 
 
Inactive(1214)
 
 
Inconclusive(216)
 
 
Unspecified(158)
 
 
Top Targets:
7TM GPCR Srx(53)
 
 
 
 
 
7TM GPCR Srsx(47)
 
 
 
 
NR LBD PPAR(34)
 
 
 
NR LBD AR(28)
 
 
 
 
 
NR LBD ER(28)
 
 
 
 
 
BioAssay Types:
Confirmatory(667)
 
 
 
 
 
Screening(648)
 
 
 
Literature(122)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(652)
 
 
 
 
 
IC50(152)
 
 
 
 
Ki(5)
 
 
EC50(4)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 940    Data Row: 1680   Total Pages: 34   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103382993]
Ki 0.00076Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand. [AID32025, Type: Literature]
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2
[SID103382993]
Ki 0.0013Adenosine A1 receptor binding was measured in adenosine deaminase (ADA) pretreated rat cortical membranes using [3H]cyclohexyladenosine in the presence of 2-chloroadenosine [AID31717, Type: Literature]
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3
[SID103382993]
IC50 0.005Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes without GTP [AID31540, Type: Literature]Adenosine receptor A1 [gi:2827766]
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4
[SID103382993]
Ki 0.014Binding affinity for human androgen receptor in transiently-transfected COS-1 cells. [AID39147, Type: Literature]
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5
[SID103382993]
IC50 0.023Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells. [AID38975, Type: Literature]
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6
[SID103382993]
IC50 0.037DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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7
[SID103382993]
IC50 0.047DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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8
[SID103382993]
IC50 0.125Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes with GTP [AID31541, Type: Literature]Adenosine receptor A1 [gi:2827766]
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9
[SID103382993]
IC50 0.225DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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10
[SID103382993]
Ki 0.336Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand. [AID33574, Type: Literature]
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11
[SID103382993]
IC50 0.63096Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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12
[SID103382993]
Ki 0.636Binding to Adenosine A2 receptor was measured in ADA-pretreated rat striatal membranes using [3H]-CGS- 21680 [AID33592, Type: Literature]
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13
[SID144208884]
Potency-Replicate_1 0.9679qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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14
[SID144213258]
Ratio Potency (uM) 1.05507qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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15
[SID144213258]
Ratio Potency (uM) 1.27825qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144204615]
Potency-Replicate_1 1.5089qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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17
[SID144204615]
Ratio Potency (uM) 1.5089qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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18
[SID144208884]
Ratio Potency (uM) 1.54788qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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19
[SID144208884]
Potency-Replicate_1 1.7367qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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20
[SID144213258]
Potency-Replicate_1 2.169qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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21
[SID103382993]
IC50 2.183DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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22
[SID26752883]
Potency 3.1623qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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23
[SID144204615]
Potency-Replicate_1 3.7578qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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24
[SID144208884]
Potency-Replicate_1 4.8508qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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25
[SID144204615]
Potency 5.0119qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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26
[SID144208884]
Potency-Replicate_1 7.6881qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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27
[SID103382993]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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28
[SID26752883]
Potency 8.4921Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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29
[SID103382993]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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30
[SID103382993]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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31
[SID26752883]
Potency 10.691Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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32
[SID144204615]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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33
[SID144208884]
Potency-Replicate_1 12.1847qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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34
[SID103382993]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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35
[SID103382993]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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36
[SID103382993]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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37
[SID46500455]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID144213258]
Potency-Replicate_1 15.3553qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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39
[SID90340797]
Potency 16.3535qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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40
[SID103382993]
IC50 18Inhibition of [3H]-R-1881 binding to rat ventral prostrate cytosolic androgen receptor [AID55258, Type: Literature]Androgen receptor [gi:113832]
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41
[SID144213258]
Potency-Replicate_1 19.3312qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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42
[SID144208884]
Potency-Replicate_1 19.4866qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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43
[SID90340797]
Potency 20.5962qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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44
[SID49737417]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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45
[SID144204615]
Potency-Replicate_1 21.1317qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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46
[SID144213258]
Potency-Replicate_1 21.6899qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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47
[SID144204615]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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48
[SID144208884]
Ratio Potency (uM) 24.3118qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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49
[SID144208884]
Potency-Replicate_1 24.3118qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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50
[SID144213258]
Potency-Replicate_1 24.5442qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743217, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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