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dihydrofolate (CID 98792) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inconclusive(2)
 
 
Unspecified(14)
 
 
Top Targets:
DHFR(14)
 
 
 
BioAssay Types:
Literature(28)
 
 
 
 
BioActivity Types:
Kd(10)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 28   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103232782]
Kd 0.21Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57251, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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2
[SID103232782]
Kd 0.22Thermodynamic dissociation constant of compound for wild type Escherichia coli dihydrofolate reductase [AID57269, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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3
[SID103232782]
Kd 0.24Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 8.5 [AID57253, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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4
[SID103232782]
Kd 0.243Thermodynamic dissociation constant of compound for mutant T46A Escherichia coli dihydrofolate reductase [AID57266, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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5
[SID103232782]
Kd 2Thermodynamic dissociation constant of compound for mutant T46N Escherichia coli dihydrofolate reductase [AID57267, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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6
[SID103232782]
Kd 2.4Thermodynamic dissociation constant of compound for mutant T46S Escherichia coli dihydrofolate reductase [AID57268, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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7
[SID103232782]
Kd 2.6Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57256, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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8
[SID103232782]
Kd 2.9Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 8.5 [AID57258, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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9
[SID103232782]
Ki 3.1Inhibition of Escherichia coli K-12 recombinant His-tagged folylpoly-gamma-glutamate synthetase expressed in Escherichia coli BL21 LC-MS/MS method [AID500671, Type: Literature]
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10
[SID103232782]
Kd 6.2Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 8.5 [AID57264, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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11
[SID103232782]
Kd 6.6Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57262, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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12
[SID103232782]
Inhibition of Escherichia coli K-12 recombinant His-tagged folylpoly-gamma-glutamate synthetase expressed in Escherichia coli BL21 at 200 uM LC-MS/MS method [AID500670, Type: Literature]
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13
[SID103232782]
Inhibitory activity against HIV-1 integrase at 1 mM [AID91439, Type: Literature]Integrase [gi:82312013]
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14
[SID103232782]
Inhibitory activity against HIV-1 integrase at 200 uM [AID91440, Type: Literature]Integrase [gi:82312013]
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15
[SID103232782]
Dissociation rate constant of compound for mutant T46A Escherichia coli dihydrofolate reductase [AID57085, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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16
[SID103232782]
Dissociation rate constant of compound for mutant T46N Escherichia coli dihydrofolate reductase [AID57086, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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17
[SID103232782]
Dissociation rate constant of compound for mutant T46S Escherichia coli dihydrofolate reductase [AID57087, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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18
[SID103232782]
Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate reductase [AID57088, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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19
[SID103232782]
Dissociation constant towards DHFR mutant F31W [AID89920, Type: Literature]
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20
[SID103232782]
Dissociation constant towards human DHFR mutant hF31S [AID89922, Type: Literature]
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