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4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid (CID 9866186) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(4)
 
 
Inconclusive(4)
 
 
Unspecified(73)
 
 
Top Targets:
NR LBD SHP(4)
 
 
 
PTPc(1)
 
 
BioAssay Types:
Literature(115)
 
 
 
 
 
BioActivity Types:
IC50(22)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 115    Data Row: 115   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103437115]
IC50 0.047Antiproliferative activity against mouse MMTV-Wnt-1 cells assessed as cell viability after 72 hrs by DAPI staining method [AID646009, Type: Literature]
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2
[SID103437115]
IC50 0.16Antiproliferative activity against human MOLT4 cells assessed as cell viability after 72 hrs by luciferase assay [AID646005, Type: Literature]
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3
[SID103437115]
IC50 0.17Antiproliferative activity against human OCI-AML2 cells assessed as cell viability after 72 hrs by luciferase assay [AID646004, Type: Literature]
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4
[SID103437115]
IC50 0.2Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50% [AID248352, Type: Literature]
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5
[SID103437115]
IC50 0.281Induction of apoptosis in mouse MMTV-Wnt-1 cells assessed as cell viability after 72 hrs by DAPI staining based cell counting [AID610164, Type: Literature]
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6
[SID103437115]
IC50 0.3Antiproliferative activity against HMVE cells [AID288576, Type: Literature]
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7
[SID103437115]
IC50 0.3Growth inhibition of primary HMVE cells after 72 hrs [AID288596, Type: Literature]
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8
[SID103437115]
IC50 0.3Inhibition of cell proliferation in retinoid-resistant KG1 cells after 48 hrs [AID288590, Type: Literature]
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9
[SID103437115]
IC50 0.4Growth inhibition of retinoid-resistant H292 cells after 72 hrs [AID288586, Type: Literature]
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10
[SID103437115]
IC50 0.4Antiproliferative activity against human H292 cells after 72 hrs by MTT assay [AID365048, Type: Literature]
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11
[SID103437115]
IC50 0.48Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay [AID365046, Type: Literature]
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12
[SID103437115]
IC50 0.5Growth inhibition of retinoid-resistant DU145 cells after 72 hrs [AID288588, Type: Literature]
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13
[SID103437115]
IC50 0.54Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by luciferase assay [AID646003, Type: Literature]
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14
[SID103437115]
IC50 0.58Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50% [AID248330, Type: Literature]
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15
[SID103437115]
IC50 0.73Concentration of compound required for inhibition of (IGROV-1/Pt1) human cisplatin resistant ovarian carcinoma cell growth by 50% [AID248756, Type: Literature]
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16
[SID103437115]
IC50 0.95Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay [AID365047, Type: Literature]
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17
[SID103437115]
IC50 1.4Antiproliferative activity against human KG1 AML cells after 48 hrs by MTT assay [AID365045, Type: Literature]
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18
[SID103437115]
IC50 1.8Growth inhibition of retinoid-resistant MDA-MB-231 cells after 72 hrs [AID288584, Type: Literature]
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19
[SID103437115]
IC50 2.1Inhibition of SHP2 overexpressed in human KG1 cells [AID364175, Type: Literature]Tyrosine-protein phosphatase non-receptor type 11 [gi:84028248]
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20
[SID103437115]
IC50 2.5Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP by liquid scintillation counting relative to 3-Cl-AHPC [AID364173, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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21
[SID103437115]
IC50 4.2Induction of apoptosis in human KG1 cells after 48 hrs by acridine orange staining [AID365043, Type: Literature]
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22
[SID103437115]
Antiproliferative activity against human PC3 cells at 4 uM after 48 hrs by MTT assay [AID420838, Type: Literature]
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23
[SID103437115]
Antiproliferative activity against human SKOV3 cells at 4 uM after 48 hrs by MTT assay [AID420839, Type: Literature]
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24
[SID103437115]
Antiproliferative activity against human A549 cells at 4 uM after 72 hrs by MTT assay [AID420840, Type: Literature]
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25
[SID103437115]
Antiproliferative activity against human MIAPaCa2 cells at 4 uM after 48 hrs by MTT assay [AID420841, Type: Literature]
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26
[SID103437115]
Antiproliferative activity against human BxPC3 cells at 4 uM after 48 hrs by MTT assay [AID420842, Type: Literature]
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27
[SID103437115]
Antiproliferative activity against human T47D cells at 4 uM after 48 hrs by MTT assay [AID420843, Type: Literature]
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28
[SID103437115]
Antiproliferative activity against human MDA-MB-468 cells at 4 uM after 48 hrs by MTT assay [AID420844, Type: Literature]
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29
[SID103437115]
Induction of apoptosis in human Jurkat T cells assessed as induction of DEVDase activity at 1 uM after 4 hrs by fluorescence assay [AID420845, Type: Literature]
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30
[SID103437115]
Induction of apoptosis in human A549 cells assessed as decrease in ATP level at 10 uM after 72 hrs by luminescence assay [AID610166, Type: Literature]
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31
[SID103437115]
Induction of apoptosis in human PC3 cells assessed as decrease in ATP level at 10 uM after 72 hrs by luminescence assay [AID610167, Type: Literature]
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32
[SID103437115]
Aqueous solubility of the compound in water at pH 5 by UV spectrophotometric analysis [AID610858, Type: Literature]
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33
[SID103437115]
Binding affinity to GST-tagged human recombinant SHP at 100 uM by NMR spectroscopy [AID646010, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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34
[SID103437115]
Inhibition of MDA-MB-468 cell proliferation at 0.5E-6M; Inhibitory activity [AID105061, Type: Literature]
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35
[SID103437115]
Displacement of [3H]9-cis-RA from Retinoic acid receptor alpha LBD [AID198193, Type: Literature]
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36
[SID103437115]
Displacement of [3H]9-cis-RA from Retinoic acid receptor RXR-alpha LBD [AID199651, Type: Literature]
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37
[SID103437115]
Growth inhibition of retinoid-resistant MDA-MB-231 cells at 1 uM relative to control [AID288585, Type: Literature]
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38
[SID103437115]
Growth inhibition of retinoid-resistant DU145 cells at 1 uM relative to control [AID288589, Type: Literature]
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39
[SID103437115]
Growth inhibition of retinoid-resistant H292 cells at 1 uM relative to control [AID288587, Type: Literature]
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40
[SID103437115]
Percent level of apoptosis induced by 72 hr of exposure with IC80 in (IGROV-1) human ovarian carcinoma cells [AID251334, Type: Literature]
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41
[SID103437115]
Induction of apoptosis in MDA-MB-231 cells at 1 uM after 96 hrs [AID288575, Type: Literature]
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42
[SID103437115]
Inhibition of HMVE cell proliferation at 0.5 uM relative to control [AID288577, Type: Literature]
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43
[SID103437115]
Induction of apoptosis in retinoid-resistant KG1 cells at 1 uM after 48 hrs [AID288582, Type: Literature]
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44
[SID103437115]
Growth inhibition of retinoid-resistant KG1 cells at 5 uM after 48 hrs [AID288583, Type: Literature]
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45
[SID103437115]
Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP at 50 uM by liquid scintillation counting relative to 3-Cl-AHPC [AID364174, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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46
[SID103437115]
Displacement of [5,5'-3H2]AHPN from recombinant human GST-SHP partner nuclear orphan receptor at 50 uM [AID288602, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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47
[SID103437115]
Inhibition of cell proliferation in retinoid-resistant KG1 cells at 1 uM after 48 hrs relative to control [AID288591, Type: Literature]
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48
[SID103437115]
Effect on tubule formation of HMVE cells in Matrigel assessed as tube length after 18 hrs [AID288601, Type: Literature]
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49
[SID103437115]
Induction of apoptosis in retinoid-resistant KG1 cells at 5 uM after 48 hrs [AID288603, Type: Literature]
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50
[SID103437115]
Induction of apoptosis in HMVE cells assessed as increase in oligonucleosome levels after 20 hrs by ELISA [AID288597, Type: Literature]
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