Proscillaridin (CID 9828429) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(71)
 
 
Inactive(336)
 
 
Inconclusive(11)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
Death TRAILR..(12)
 
 
 
 
7TM GPCR Srsx(6)
 
 
 
PP1c bdg(6)
 
 
 
Nuc rec co-ac..(4)
 
 
BioAssay Types:
Screening(314)
 
 
 
 
Confirmatory(105)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(78)
 
 
 
 
 
IC50(19)
 
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 416    Data Row: 429   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463137]
Potency 0.0073qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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2
[SID56463137]
Potency 0.0092qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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3
[SID56463137]
Potency 0.0146qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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4
[SID56463137]
CC50 0.05Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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5
[SID56463137]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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6
[SID56463137]
AbsAC35_uM 0.09Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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7
[SID56463137]
AC50 0.16Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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8
[SID56463137]
AC50 0.16Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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9
[SID56463137]
IC50 0.16Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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10
[SID56463137]
IC50 0.16Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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11
[SID56463137]
IC50 0.45Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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12
[SID56463137]
IC50 1.66Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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13
[SID56463137]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504539, Type: confirmatory]
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14
[SID56463137]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_CherryPick_Activity [AID504592, Type: confirmatory]
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15
[SID56463137]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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16
[SID56463137]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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17
[SID56463137]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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18
[SID56463137]
 Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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19
[SID56463137]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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20
[SID85787536]
 Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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21
[SID56463137]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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22
[SID56463137]
 uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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23
[SID56463137]
 HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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24
[SID56463137]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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25
[SID56463137]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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26
[SID56463137]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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27
[SID56463137]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]
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28
[SID56463137]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]
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29
[SID56463137]
 Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID652007, Type: screening]
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30
[SID56463137]
 Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID652008, Type: screening]
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31
[SID56463137]
 QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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32
[SID56463137]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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33
[SID56463137]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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34
[SID56463137]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]NCOA2 gene product [Homo sapiens] [gi:5729858]
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35
[SID56463137]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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36
[SID56463137]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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37
[SID56463137]
 Single concentration confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID651580, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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38
[SID56463137]
 Single concentration confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID651580, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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39
[SID56463137]
 uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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40
[SID56463137]
 uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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41
[SID56463137]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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42
[SID56463137]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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43
[SID56463137]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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44
[SID56463137]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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45
[SID56463137]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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46
[SID56463137]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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47
[SID56463137]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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48
[SID56463137]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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49
[SID56463137]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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50
[SID56463137]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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