Bookmark and Share
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan (CID 9826034) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(50)
 
 
Inactive(42)
 
 
Inconclusive(17)
 
 
Unspecified(22)
 
 
Top Targets:
7tm 4(13)
 
 
 
 
 
PIKKc TOR(4)
 
 
 
Pyr redox dim(4)
 
 
 
SIS(3)
 
 
Hexokinase 2(3)
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
 
Literature(64)
 
 
 
 
 
BioActivity Types:
Potency(68)
 
 
 
 
Ki(25)
 
 
Kd(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 124    Data Row: 131   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103583410]
Ki 3e-05Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells [AID148585, Type: Literature]
View
2
[SID103583410]
Kd 3.98e-05Antagonistic activity against human cloned kOpioid receptor kappa 1 using U69,593 in [35S]GTP-gamma-S, assay [AID148169, Type: Literature]
View
3
[SID103583410]
Ki 6e-05Mutant factor of the compound against mu-[K303E] with Opioid receptor kappa 1 for binding affinity [AID148599, Type: Literature]
View
4
[SID103583410]
Ki 9e-05Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expressed as binding affinity. [AID148588, Type: Literature]
View
5
[SID103583410]
Ki 9e-05Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 cells [AID152386, Type: Literature]
View
6
[SID103583410]
Ki 0.00014Binding affinity towards rat opioid receptor kappa 1 was determined using [3H]diprenorphine radioligand [AID148575, Type: Literature]
View
7
[SID103583410]
Ki 0.00015Displacement of [125I]-IBNtxA from KOR-1 expressed in CHO cells [AID603174, Type: Literature]
View
8
[SID103583410]
Ki 0.00018Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells [AID148586, Type: Literature]
View
9
[SID103583410]
Ki 0.00018Binding affinity on HEK293 cells transiently transfected with plasmids encoding the rat Opioid receptor kappa 1 [AID148568, Type: Literature]
View
10
[SID103583410]
Ki 0.00018Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brain [AID149260, Type: Literature]Kappa-type opioid receptor [gi:730228]
View
11
[SID103583410]
Ki 0.00019Displacement of [125I]-IBNalA from KOR-1 expressed in CHO cells [AID603175, Type: Literature]
View
12
[SID103583410]
Ki 0.00021Effect on binding to wild-type opioid receptor kappa 1 using [3H]diprenorphine in transiently expressed rat HEK293 cells [AID148590, Type: Literature]
View
13
[SID103583410]
Ki 0.0005Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 cells [AID152388, Type: Literature]
View
14
[SID103583410]
Ki 0.0011Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells [AID149086, Type: Literature]
View
15
[SID103583410]
Kd 0.00324Antagonistic activity against human cloned Opioid receptor mu 1 using DPDPE in [35S]GTP-gamma-S, assay [AID151116, Type: Literature]
View
16
[SID103583410]
Ki 0.0039Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells [AID148584, Type: Literature]
View
17
[SID103583410]
Ki 0.00393Effect on binding to kappa(Glu297Ala) opioid receptor, using [3H]diprenorphine in transiently expressed rat HEK293 cells [AID148589, Type: Literature]
View
18
[SID103583410]
Ki 0.00923Effect on binding affinity of mutational exchange of Lys303 in the Opioid receptor mu 1 in transiently expressed rat cos-7 cells activity expressed as binding affinity. [AID151766, Type: Literature]
View
19
[SID103583410]
Ki 0.0129Mutant factor of the compound against kappa[E297K] with Opioid receptor kappa 1 for binding affinity. [AID148598, Type: Literature]
View
20
[SID103583410]
Kd 0.01549Antagonistic activity against human cloned Opioid receptor delta 1 using DPDPE in [35S]GTP-gamma-S, assay [AID148383, Type: Literature]
View