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N-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin (CID 9822159) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Unspecified(13)
 
 
Top Targets:
Glucosylceram..(4)
 
 
GH31 MGAM SI..(2)
 
 
DUF608(2)
 
 
GH31(1)
 
 
Glyco hydro 3..(1)
 
 
BioAssay Types:
Literature(47)
 
 
 
BioActivity Types:
IC50(30)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 57    Data Row: 57   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103698575]
IC50 0.0003Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cells [AID700851, Type: Literature]
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2
[SID103698575]
IC50 0.001Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis [AID652573, Type: other]Non-lysosomal glucosylceramidase [gi:143018392]
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3
[SID103698575]
IC50 0.001Inhibition of human GBA2 [AID437994, Type: Literature]Non-lysosomal glucosylceramidase [gi:143018392]
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4
[SID103698575]
IC50 0.001Inhibition of GBA2 by HPLC [AID466671, Type: Literature]
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5
[SID103698575]
IC50 0.001Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay [AID553254, Type: other]
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6
[SID103698575]
IC50 0.002Inhibition of non-lysosomal glucosylceramidase [AID700852, Type: Literature]
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7
[SID103698575]
IC50 0.09Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis [AID699203, Type: Literature]
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8
[SID103698575]
IC50 0.09Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction [AID626355, Type: Literature]
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9
[SID103698575]
IC50 0.13Inhibition of rice alpha glucosidase [AID437996, Type: Literature]
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10
[SID103698575]
IC50 0.15Inhibition of GCS by cell-based assay [AID466666, Type: Literature]
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11
[SID103698575]
IC50 0.2Inhibition of human GBA1 [AID437993, Type: Literature]
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12
[SID103698575]
IC50 0.2Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay [AID553253, Type: other]
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13
[SID103698575]
IC50 0.2Inhibition of recombinant glucosylceramidase 1 using 4-methylumbelliferyl-B-glucoside as substrate by fluorimetric analysis [AID652572, Type: other]
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14
[SID103698575]
IC50 0.2Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence scanner [AID652571, Type: other]Ceramide glucosyltransferase [gi:38257364]
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15
[SID103698575]
IC50 0.2Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay [AID553252, Type: other]Ceramide glucosyltransferase [gi:38257364]
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16
[SID103698575]
IC50 0.2Inhibition of GBA1 by HPLC [AID466670, Type: Literature]
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17
[SID103698575]
IC50 0.4Inhibition of human lysosomal alpha glucosidase [AID437995, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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18
[SID103698575]
IC50 0.4Inhibition of lysosomal alpha-glucosidase by HPLC [AID466672, Type: Literature]
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19
[SID103698575]
IC50 0.5Inhibition of sucrase by HPLC [AID466667, Type: Literature]
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20
[SID103698575]
IC50 0.5Inhibition of sucrase in mouse intestinal input by glucose release assay [AID553255, Type: other]Sucrase-isomaltase, intestinal [Cricetulus griseus] [gi:344247361]
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21
[SID103698575]
IC50 0.9Inhibition of Bacillus stearothermophilus alpha glucosidase [AID437998, Type: Literature]
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22
[SID103698575]
IC50 1Inhibition of Saccharomyces cerevisiae alpha glucosidase [AID437997, Type: Literature]
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23
[SID103698575]
IC50 4Inhibition of maltase by HPLC [AID466668, Type: Literature]
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24
[SID103698575]
IC50 4Inhibition of maltase in mouse intestinal input by glucose release assay [AID553257, Type: other]Lysosomal alpha-glucosidase [gi:51338793]
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25
[SID103698575]
IC50 10Inhibition of glycogen glycogen de-branching enzyme by HPLC [AID466673, Type: Literature]
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26
[SID103698575]
IC50 16.5Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assay [AID699202, Type: Literature]Ceramide glucosyltransferase [gi:2498228]
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27
[SID103698575]
IC50 16.5Inhibition of GCS activity in human A549 cells assessed as amount of GM1 on the cell membrane after 72 hrs by FL-CTB-based fluorescent microscopy [AID626356, Type: Literature]Ceramide glucosyltransferase [gi:2498228]
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28
[SID103698575]
IC50 35Inhibition of lactase in mouse intestinal input by glucose release assay [AID553256, Type: other]Beta-galactosidase [gi:114944]
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29
[SID103698575]
IC50 35Inhibition of lactase by HPLC [AID466669, Type: Literature]
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30
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in liver glycosphingolipids at 100 mg/kg/day for 4 weeks [AID466864, Type: Literature]
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31
[SID103698575]
Antidiabetic activity in ZDF rat assessed as reduction in plasma glycosphingolipids at 20 to 100 mg/kg/day for 4 weeks [AID466865, Type: Literature]
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32
[SID103698575]
Antidiabetic activity in ZDF rat assessed as reduction in liver glycosphingolipids at 20 to 100 mg/kg/day for 4 weeks [AID466866, Type: Literature]
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33
[SID103698575]
Antidiabetic activity in ZDF rat assessed as improvement in blood glucose concentration at 20 to 100 mg/kg/day for 4 weeks [AID466867, Type: Literature]
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34
[SID103698575]
Antidiabetic activity in ZDF rat assessed as improvement in HbA1c levels at 20 to 100 mg/kg/day for 4 weeks [AID466868, Type: Literature]
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35
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in plasma glycosphingolipids at 100 mg/kg/day for 4 weeks [AID466674, Type: Literature]
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36
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in blood glucose at 100 mg/kg/day for 4 weeks [AID466852, Type: Literature]
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37
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in blood insulin at 100 mg/kg/day for 4 weeks [AID466853, Type: Literature]
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38
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as increase in glucose tolerance at 100 mg/kg/day for 4 weeks by OGTT [AID466854, Type: Literature]
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39
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as insulin resistance at 100 mg/kg/day for 4 weeks by HOMA-IR analysis [AID466855, Type: Literature]
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40
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in HbA1c at 100 mg/kg/day for 4 weeks [AID466856, Type: Literature]
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41
[SID103698575]
Inhibition of GCS in C57/B6 mouse assessed as decrease in liver GM3 level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis [AID699186, Type: Literature]
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42
[SID103698575]
Inhibition of GCS in C57/B6 mouse assessed as decrease in liver lactosylceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis [AID699187, Type: Literature]
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43
[SID103698575]
Inhibition of GCS in C57/B6 mouse assessed as decrease in liver glucosylceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis [AID699188, Type: Literature]
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44
[SID103698575]
Inhibition of GCS in C57/B6 mouse assessed as decrease in liver ceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis [AID699189, Type: Literature]
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45
[SID103698575]
IC50 100Inhibition of sweet almond beta glucosidase [AID437999, Type: Literature]
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46
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as blood glucose AUC at 100 mg/kg/day, po treated for 4 weeks followed by 1 g/kg sucrose treatment after last dose measured after 1 hr after sucrose challenge (Rvb=1325+/-210 mM.min) [AID466869, Type: Literature]
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47
[SID103698575]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as blood glucose AUC at 100 mg/kg/day, po treated for 6 weeks administered 1 g/kg sucrose treatment at end of week 4 followed by 0.5 g/kg glucose treatment at end of week 6 measured after 1 hr after glucose challenge (Rvb=1560+/-245 mM.min) [AID466870, Type: Literature]
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48
[SID103698575]
Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide synthase in mouse RAW cells [AID553258, Type: other]
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49
[SID103698575]
Cmax in ZDE/Crl-leprfa rat at 3 mg/kg, iv [AID466857, Type: Literature]
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50
[SID103698575]
Dose normalized Cmax in ZDE/Crl-leprfa rat at 3 mg/kg, iv [AID466858, Type: Literature]
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