N-desmethyl loperamide (CID 9805944) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Unspecified(33)
 
 
Top Targets:
7TM GPCR Srx(8)
 
 
ERG2 Sigma1R(2)
 
 
 
SLC6sbd SERT(2)
 
 
 
7TM GPCR Srsx(1)
 
 
7TM GPCR Srv(1)
 
 
BioAssay Types:
Literature(45)
 
 
 
BioActivity Types:
Ki(12)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 45   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103606134]
Ki 0.0006Displacement of [3H]DAMGO from mu opioid receptor [AID391603, Type: Literature]
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2
[SID103606134]
Ki 0.0008Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cells [AID391604, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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3
[SID103606134]
Ki 0.0008Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cells [AID391604, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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4
[SID103606134]
Ki 0.001Displacement of [125I]HEAT from adrenergic alpha2A receptor [AID391596, Type: Literature]
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5
[SID103606134]
Ki 0.0011Displacement of [3H]N-methylspiperone from dopamine D4 receptor [AID391599, Type: Literature]
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6
[SID103606134]
Ki 0.0017Displacement of [3H]tiotidine from human histamine H2 receptor [AID391601, Type: Literature]Histamine H2 receptor [gi:123120]
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7
[SID103606134]
Ki 0.0017Displacement of [3H]tiotidine from human histamine H2 receptor [AID391601, Type: Literature]Histamine H2 receptor [gi:123120]
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8
[SID103606134]
Ki 0.0017Displacement of [3H]tiotidine from human histamine H2 receptor [AID391601, Type: Literature]Histamine H2 receptor [gi:123120]
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9
[SID103606134]
Ki 0.0019Displacement of [3H]DTG from rat sigma 2 receptor in rat PC12 cells [AID391605, Type: Literature]
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10
[SID103606134]
Ki 0.0024Displacement of [125I]HEAT from adrenergic Alpha-2C receptor [AID391597, Type: Literature]
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11
[SID103606134]
Ki 0.0042Displacement of [3H]pyrilamine from human histamine H1 receptor [AID391600, Type: Literature]Histamine H1 receptor [gi:547645]
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12
[SID103606134]
Ki 0.0042Displacement of [3H]pyrilamine from human histamine H1 receptor [AID391600, Type: Literature]Histamine H1 receptor [gi:547645]
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13
[SID103606134]
Ki 0.0062Displacement of [3H]citalopram from human SERT [AID391606, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103606134]
Ki 0.0062Displacement of [3H]citalopram from human SERT [AID391606, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103606134]
Ki 0.0062Displacement of [3H]citalopram from human SERT [AID391606, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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16
[SID103606134]
Ki 0.007Displacement of [125I]HEAT from adrenergic alpha2B receptor [AID391598, Type: Literature]
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17
[SID103606134]
Ki 0.0093Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor [AID391602, Type: Literature]Histamine H3 receptor [gi:17367264]
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18
[SID103606134]
Ki 0.0093Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor [AID391602, Type: Literature]Histamine H3 receptor [gi:17367264]
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19
[SID103606134]
Ki 0.0099Displacement of [125I]HEAT from adrenergic alpha1A receptor [AID391595, Type: Literature]
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20
[SID103606134]
 Dissociation constant, pKa of the compound [AID391287, Type: Literature]
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21
[SID103606134]
 Displacement of [3H]pyrilamine from human histamine H1 receptor at 10 uM [AID391313, Type: Literature]Histamine H1 receptor [gi:547645]
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22
[SID103606134]
 Displacement of [3H]pyrilamine from human histamine H1 receptor at 10 uM [AID391313, Type: Literature]Histamine H1 receptor [gi:547645]
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23
[SID103606134]
 Displacement of [3H]tiotidine from human histamine H2 receptor at 10 uM [AID391314, Type: Literature]Histamine H2 receptor [gi:123120]
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24
[SID103606134]
 Displacement of [3H]tiotidine from human histamine H2 receptor at 10 uM [AID391314, Type: Literature]Histamine H2 receptor [gi:123120]
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25
[SID103606134]
 Displacement of [3H]tiotidine from human histamine H2 receptor at 10 uM [AID391314, Type: Literature]Histamine H2 receptor [gi:123120]
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26
[SID103606134]
 Displacement of [3H]iodopindolol from adrenergic beta-1 receptor at 10 uM [AID391295, Type: Literature]
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27
[SID103606134]
 Displacement of [3H]iodopindolol from adrenergic beta2 receptor at 10 uM [AID391296, Type: Literature]
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28
[SID103606134]
 Displacement of [125I]HEAT from adrenergic alpha1A receptor at 10 uM [AID391308, Type: Literature]
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29
[SID103606134]
 Displacement of [125I]HEAT from adrenergic alpha2A receptor at 10 uM [AID391309, Type: Literature]
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30
[SID103606134]
 Displacement of [125I]HEAT from adrenergic alpha2B receptor at 10 uM [AID391310, Type: Literature]
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31
[SID103606134]
 Displacement of [125I]HEAT from adrenergic Alpha-2C receptor at 10 uM [AID391311, Type: Literature]
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32
[SID103606134]
 Displacement of [3H]N-methylspiperone from dopamine D4 receptor at 10 uM [AID391312, Type: Literature]
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33
[SID103606134]
 Displacement of [3H]DAMGO from mu opioid receptor at 10 uM [AID391316, Type: Literature]
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34
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M1 receptor at 10 uM [AID391300, Type: Literature]Muscarinic acetylcholine receptor M [gi:113118]
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35
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M1 receptor at 10 uM [AID391300, Type: Literature]Muscarinic acetylcholine receptor M [gi:113118]
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36
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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37
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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38
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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39
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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40
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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41
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M2 receptor at 10 uM [AID391301, Type: Literature]Muscarinic acetylcholine receptor M [gi:113122]
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42
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM [AID391302, Type: Literature]Muscarinic acetylcholine receptor M [gi:113125]
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43
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM [AID391302, Type: Literature]Muscarinic acetylcholine receptor M [gi:113125]
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44
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM [AID391302, Type: Literature]Muscarinic acetylcholine receptor M [gi:113125]
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45
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM [AID391302, Type: Literature]Muscarinic acetylcholine receptor M [gi:113125]
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46
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M3 receptor at 10 uM [AID391302, Type: Literature]Muscarinic acetylcholine receptor M [gi:113125]
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47
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M4 receptor at 10 uM [AID391303, Type: Literature]Muscarinic acetylcholine receptor M [gi:23503039]
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48
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M4 receptor at 10 uM [AID391303, Type: Literature]Muscarinic acetylcholine receptor M [gi:23503039]
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49
[SID103606134]
 Displacement of [3H]QNB from human muscarinic M4 receptor at 10 uM [AID391303, Type: Literature]Muscarinic acetylcholine receptor M [gi:23503039]
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50
[SID103606134]
 Displacement of [3H]SCH23390 from human dopamine D1 receptor at 10 uM [AID391297, Type: Literature]D(1A) dopamine receptor [gi:118228]
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