Bookmark and Share
GW 501516 (CID 9803963) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(71)
 
 
Inactive(25)
 
 
Inconclusive(11)
 
 
Unspecified(71)
 
 
Top Targets:
NR LBD PPAR(101)
 
 
 
 
PTKc Yes(1)
 
 
BioAssay Types:
Literature(150)
 
 
 
 
 
Confirmatory(27)
 
 
 
 
BioActivity Types:
EC50(56)
 
 
 
Potency(29)
 
 
 
 
IC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 174    Data Row: 178   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103215364]
EC50 3e-05Induction of [14C]oleic acid oxidation in a human myotubes after 4 days by beta liquid scintillation counting [AID635193, Type: Literature]
View
2
[SID103215364]
EC50 7e-05Induction of [14C]-oleic acid oxidation in human differentiated skeletal muscle cells assessed as accumulation of oxidized [14C]-oleic acid after 4 hrs by by liquid scintillation counting [AID490433, Type: Literature]
View
3
[SID103215364]
EC50 0.001Maximum transcriptional activation of human PPAR delta receptor [AID156617, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
4
[SID103215364]
IC50 0.001Binding affinity for human PPAR delta receptor [AID156625, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
5
[SID103215364]
EC50 0.001Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells [AID270378, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
6
[SID103215364]
EC50 0.0012Transactivation of human PPARdelta expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID662545, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
7
[SID103215364]
EC50 0.0012Agonist activity at human PPARdelta expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552401, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
8
[SID103215364]
EC50 0.0017Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID551967, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
9
[SID103215364]
EC50 0.0017Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay [AID597762, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
10
[SID103215364]
EC50 0.0018Effect on PPARdelta transactivation activity in HEK293 cells [AID288974, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
11
[SID103215364]
EC50 0.002Agonist activity at Gal4-fused human PPARdelta DNA binding domain expressed in HEK293 cells by luciferase reporter gene assay [AID551019, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
12
[SID103215364]
EC50 0.0025Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay [AID663629, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
13
[SID103215364]
IC50 0.0026Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA [AID299417, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
14
[SID103215364]
EC50 0.0029Agonist activity at human PPARdelta ligand binding domain expressed in COS-1 cells after 24 hrs by luciferase reporter gene-based luminometric analysis [AID635240, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
15
[SID103215364]
EC50 0.003Agonist activity at PPARdelta by transactivation assay [AID268884, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
16
[SID103215364]
EC50 0.00316Agonist activity at human PPARdelta by Gal4 chimera cell-based reporter assay [AID348376, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
17
[SID103215364]
EC50 0.00316Partial agonist activity at human PPARdelta expressed in african green monkey CV1 cells transfected with Gal4 assessed as beta-galactosidase activity by transactivation assay [AID591223, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
18
[SID103215364]
EC50 0.004Agonist activity at human PPARdelta in HepG2 cells by GAL4-luciferase reporter gene assay [AID299420, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
19
[SID103215364]
IC50 0.005Agonist activity at PPARdelta [AID665204, Type: Literature]
View
20
[SID103215364]
EC50 0.005Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells co-transfected with Gal4-DBD by luciferase transactivation assay [AID469785, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View