Bookmark and Share
GW 501516 (CID 9803963) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(67)
 
 
Inactive(22)
 
 
Inconclusive(11)
 
 
Unspecified(71)
 
 
Top Targets:
NR LBD PPAR(98)
 
 
 
 
PTKc Src like(1)
 
 
BioAssay Types:
Literature(147)
 
 
 
 
 
Confirmatory(24)
 
 
 
BioActivity Types:
EC50(56)
 
 
 
Potency(25)
 
 
 
IC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 167    Data Row: 171   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103215364]
EC50 3e-05Induction of [14C]oleic acid oxidation in a human myotubes after 4 days by beta liquid scintillation counting [AID635193, Type: Literature]
View
2
[SID103215364]
EC50 7e-05Induction of [14C]-oleic acid oxidation in human differentiated skeletal muscle cells assessed as accumulation of oxidized [14C]-oleic acid after 4 hrs by by liquid scintillation counting [AID490433, Type: Literature]
View
3
[SID103215364]
EC50 0.001Maximum transcriptional activation of human PPAR delta receptor [AID156617, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
4
[SID103215364]
IC50 0.001Binding affinity for human PPAR delta receptor [AID156625, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
5
[SID103215364]
EC50 0.001Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells [AID270378, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
6
[SID103215364]
EC50 0.0012Agonist activity at human PPARdelta expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552401, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
7
[SID103215364]
EC50 0.0012Transactivation of human PPARdelta expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID662545, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
8
[SID103215364]
EC50 0.0017Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay [AID597762, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
9
[SID103215364]
EC50 0.0017Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID551967, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
10
[SID103215364]
EC50 0.0018Effect on PPARdelta transactivation activity in HEK293 cells [AID288974, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
11
[SID103215364]
EC50 0.002Agonist activity at Gal4-fused human PPARdelta DNA binding domain expressed in HEK293 cells by luciferase reporter gene assay [AID551019, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
12
[SID103215364]
EC50 0.0025Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay [AID663629, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
13
[SID103215364]
IC50 0.0026Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA [AID299417, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
14
[SID103215364]
EC50 0.0029Agonist activity at human PPARdelta ligand binding domain expressed in COS-1 cells after 24 hrs by luciferase reporter gene-based luminometeric analysis [AID635240, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
15
[SID103215364]
EC50 0.003Agonist activity at PPARdelta by transactivation assay [AID268884, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
16
[SID103215364]
EC50 0.00316Agonist activity at human PPARdelta by Gal4 chimera cell-based reporter assay [AID348376, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
17
[SID103215364]
EC50 0.00316Partial agonist activity at human PPARdelta expressed in african green monkey CV1 cells transfected with Gal4 assessed as beta-galactosidase activity by transactivation assay [AID591223, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
18
[SID103215364]
EC50 0.004Agonist activity at human PPARdelta in HepG2 cells by GAL4-luciferase reporter gene assay [AID299420, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
19
[SID103215364]
EC50 0.005Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells co-transfected with Gal4-DBD by luciferase transactivation assay [AID469785, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
20
[SID103215364]
IC50 0.005Agonist activity at PPARdelta [AID665204, Type: Literature]
View
21
[SID103215364]
IC50 0.00501Displacement of [3H]GW 2433 from human PPARdelta by competition-binding assay [AID348375, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
22
[SID103215364]
IC50 0.00501Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assay [AID591220, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
23
[SID103215364]
EC50 0.006Agonist activity at human PPARdelta ligand binding domain by FRET assay [AID469789, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
24
[SID103215364]
EC50 0.006Effect on fatty acid oxidation in rat L6 cells [AID280963, Type: Literature]
View
25
[SID103215364]
EC50 0.0079Activity at human placenta PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assay [AID280960, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
26
[SID103215364]
EC50 0.008Agonist activity at human PPARdelta by transactivation assay [AID308433, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
27
[SID103215364]
EC50 0.008Agonist activity at human PPARdelta by transactivation assay [AID299625, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
28
[SID103215364]
EC50 0.008Agonist activity at PPARdelta ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay [AID417011, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
29
[SID103215364]
EC50 0.02Activity against murine PPAR delta receptor [AID156784, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
30
[SID103215364]
EC50 0.024Binding affinity at human GST-tagged PPARdelta ligand binding domain after 1 hr by time-resolved FRET analysis [AID663659, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
31
[SID103215364]
EC50 0.054Agonist activity at mouse PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assay [AID280994, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
32
[SID103215364]
EC50 0.077Agonist activity at mouse PPARdelta by FRET assay [AID469797, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
33
[SID103215364]
EC50 0.085Agonist activity at human PPARdelta receptor expressed in HEK293 cells by GAL4 transactivation assay [AID308146, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
34
[SID103215364]
IC50 0.12589Antagonist activity at human PPARdelta ligand binding domain-mediated transcriptional activity in CV1 cells by Gal4 chimera reporter assay [AID459604, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
35
[SID103215364]
EC50 0.229Transactivation activity at human PPARalpha expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay [AID663627, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
36
[SID103215364]
IC50 0.463Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA [AID299418, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
37
[SID103215364]
EC50 0.8Agonist activity at human PPARgamma expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552196, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
38
[SID103215364]
EC50 0.85Maximum transcriptional activation of human PPAR gamma receptor [AID156945, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
39
[SID103215364]
EC50 0.912Agonist activity at human PPARgamma ligand binding domain expressed in COS-1 cells after 24 hrs by luciferase reporter gene-based luminometeric analysis [AID635239, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
40
[SID103215364]
EC50 0.99Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID551965, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
41
[SID103215364]
EC50 0.99Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay [AID597760, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
42
[SID103215364]
EC50 1Effect on PPARalpha transactivation activity in HEK293 cells [AID288973, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
43
[SID103215364]
EC50 1Activity against murine PPAR gamma receptor [AID157278, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
44
[SID103215364]
EC50 1.1Maximum transcriptional activation of human PPAR alpha receptor [AID156147, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
45
[SID103215364]
EC50 1.1Agonist activity at human PPARalpha expressed in HepG2 cells co-transfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 hrs by luciferase based transactivation assay [AID552193, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
46
[SID103215364]
EC50 1.23Agonist activity at PPARalpha by transactivation assay [AID268883, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
47
[SID103215364]
IC50 1.99526Displacement of radiolabeled ligand from human PPARalpha by competition-binding assay [AID348373, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
48
[SID103215364]
IC50 1.99526Displacement of [3H]GW 2433 from human PPARalpha by scintillation proximity assay [AID591221, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
49
[SID103215364]
IC50 1.99526Agonist activity at PPARalpha [AID665203, Type: Literature]
View
50
[SID103215364]
EC50 2.5Activity against murine PPAR alpha receptor [AID156452, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View