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4-nitrophenol (CID 980) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(132)
 
 
Inconclusive(37)
 
 
Unspecified(70)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
NR LBD AR(14)
 
 
 
 
GT1 Gtf like(14)
 
 
NR LBD ER(14)
 
 
 
NR LBD Fxr(8)
 
 
 
BioAssay Types:
Confirmatory(124)
 
 
 
 
Literature(63)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(160)
 
 
 
 
IC50(5)
 
 
 
Kd(4)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 169    Data Row: 255   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144209642]
Ratio Potency (uM) 0.001qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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2
[SID103176149]
Kd 3Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102H double mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728450, Type: Literature]
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3
[SID103176149]
IC50 10.994Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay [AID303043, Type: Literature]
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4
[SID103176149]
IC50 12.994Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay [AID303044, Type: Literature]
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5
[SID144210437]
Potency-Replicate_1 27.306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144210437]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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7
[SID144210437]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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8
[SID144209642]
Potency-Replicate_1 56.5948qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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9
[SID144210437]
Ratio Potency (uM) 57.711qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144210437]
Potency-Replicate_1 61.1306qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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11
[SID144210437]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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12
[SID144209642]
Potency-Replicate_1 63.5004qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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13
[SID144209642]
Potency-Replicate_1 63.5004qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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14
[SID144209642]
Potency-Replicate_1 71.2487qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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15
[SID144209642]
Potency-Replicate_1 71.2487qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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16
[SID48415026]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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17
[SID103176149]
Kd 123Binding affinity to Enterobacteria phage T4 lysozyme L99A/M102Q double mutant expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry [AID728448, Type: Literature]
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18
[SID103176149]
IC50 6830Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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19
[SID103176149]
Km 11600Binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4) [AID214939, Type: Literature]
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20
[SID103176149]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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21
[SID103176149]
Permeability coefficient in silicon membrane using diffusion cells [AID266760, Type: Literature]
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22
[SID103176149]
Effective permeability coefficient in 100% silicon membrane [AID266761, Type: Literature]
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23
[SID103176149]
Effective permeability coefficient in 100% IPM membrane [AID266762, Type: Literature]
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24
[SID103176149]
Membrane retention in 70% silicon-30% IPM membrane [AID266763, Type: Literature]
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25
[SID103176149]
Membrane permeability, CA(t)/CD(0) in 70% silicon-30% IPM membrane [AID266764, Type: Literature]
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26
[SID103176149]
Effective permeability coefficient in 70% silicon-30% IPM membrane [AID266765, Type: Literature]
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27
[SID103176149]
Dissociation constant, pKa of the compound [AID266766, Type: Literature]
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28
[SID103176149]
Membrane retention in 100% silicon membrane [AID266767, Type: Literature]
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29
[SID103176149]
Membrane permeability, CA(t)/CD(0) in 100% silicon membrane [AID266768, Type: Literature]
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30
[SID103176149]
Membrane retention in 100% IPM membrane [AID266769, Type: Literature]
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31
[SID103176149]
Membrane permeability, CA(t)/CD(0) in 100% IPM membrane [AID266770, Type: Literature]
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32
[SID103176149]
Permeability in human skin [AID266771, Type: Literature]
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33
[SID103176149]
Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM [AID282833, Type: Literature]
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34
[SID103176149]
Activity against caspase-mediated apoptosis in mouse L1210 cells [AID282834, Type: Literature]
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35
[SID103176149]
IC50 Cytotoxicity against mouse L1210 cells [AID282835, Type: Literature]
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36
[SID103176149]
Cytotoxicity against human CCRF-CEM cells [AID282838, Type: Literature]
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37
[SID103176149]
Cytotoxicity against human CEM/VLB cells [AID282839, Type: Literature]
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38
[SID103176149]
Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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39
[SID103176149]
Compound was tested for the inhibitory activity against cobra venom PLA2 (Naja naja atra) by using the Dole assay [AID158632, Type: Literature]
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40
[SID103176149]
Apparent rate constant against phospholipase A2 enzyme inactivation by using pseudo first-order kinetics was evaluated [AID158633, Type: Literature]
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41
[SID103176149]
Toxicity determined using Microtox Test [AID159270, Type: Literature]
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42
[SID103176149]
Partition coefficient (logP) [AID15680, Type: Literature]
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43
[SID103176149]
Partition coefficient of compound was measured in haptane/water system [AID19254, Type: Literature]
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44
[SID103176149]
Partition coefficient (logP) [AID19255, Type: Literature]
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45
[SID103176149]
Partition coefficient (logP) [AID23251, Type: Literature]
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46
[SID103176149]
Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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47
[SID103176149]
Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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48
[SID103176149]
Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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49
[SID103176149]
Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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50
[SID103176149]
Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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