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Ergotamine (CID 9787) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(37)
 
 
Inactive(128)
 
 
Inconclusive(91)
 
 
Unspecified(1)
 
 
Top Targets:
NR LBD AR(21)
 
 
 
 
NR LBD ER(21)
 
 
 
 
NR LBD PPAR(19)
 
 
 
 
NR LBD GR(12)
 
 
 
NR LBD TR(9)
 
 
 
 
BioAssay Types:
Confirmatory(183)
 
 
 
 
Summary(63)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(232)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 104    Data Row: 257   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204734]
Ratio Potency (uM) 2.98493qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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2
[SID144204734]
Potency-Replicate_1 4.2163qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID144208903]
Potency-Replicate_1 4.9194qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
4
[SID144208903]
Ratio Potency (uM) 5.95998qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
5
[SID144213499]
Potency-Replicate_1 8.0346qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
6
[SID144204734]
Potency-Replicate_1 9.4392qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
7
[SID144208903]
Potency-Replicate_1 9.728qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
8
[SID144213499]
Ratio Potency (uM) 9.8192qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
9
[SID144213499]
AhR Potency (uM) 11.3491qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
10
[SID144208903]
Potency-Replicate_1 13.7411qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
11
[SID144208903]
Potency-Replicate_1 13.7411qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
12
[SID144208903]
Ratio Potency (uM) 14.2787qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
13
[SID144213499]
Potency-Replicate_1 14.4126qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
14
[SID144204734]
Potency-Replicate_1 16.7855qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
View
15
[SID144213499]
Potency-Replicate_1 17.9872qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
16
[SID144213499]
Potency-Replicate_1 17.9872qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
17
[SID144204734]
Potency-Replicate_1 21.1317qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
18
[SID144204734]
Potency 21.136qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
19
[SID144208903]
Potency-Replicate_1 21.7782qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
View
20
[SID144204734]
Ratio Potency (uM) 22.1476qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
21
[SID144213499]
Potency-Replicate_1 22.6445qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
View
22
[SID144213499]
Potency-Replicate_1 22.6445qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
23
[SID144204734]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
24
[SID144204734]
Potency 23.715qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
25
[SID144208903]
Potency-Replicate_1 24.4355qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
26
[SID144208903]
Potency-Replicate_1 27.4171qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
View
27
[SID144208903]
Potency-Replicate_1 27.4171qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
28
[SID144208903]
Potency-Replicate_1 34.8267qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
View
29
[SID144208903]
Ratio Potency (uM) 40.6049qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
30
[SID144208903]
Potency-Replicate_1 49.194qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway [AID743223, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
31
[SID144208903]
AhR Potency (uM) 54.7044qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
32
[SID144208903]
Potency-Replicate_1 54.7044qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
33
[SID144208903]
Potency-Replicate_1 55.1965qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743217, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
View
34
[SID144208903]
Potency-Replicate_1 61.9315qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
35
[SID144208903]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
36
[SID144204734]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
View
37
[SID144204734]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
View
38
[SID144204734]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
39
[SID144213499]
Potency-Replicate_1 22.8425qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
40
[SID144204734]
Potency-Replicate_1 23.7101qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
View
41
[SID144204734]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
42
[SID144204734]
Potency-Replicate_1 26.8325qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
43
[SID144208903]
Potency-Replicate_1 30.7625qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
View
44
[SID144208903]
Potency-Replicate_1 39.0762qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
45
[SID144208903]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
46
[SID144213499]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
47
[SID144213499]
ER Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
48
[SID144213499]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
49
[SID144213499]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
50
[SID144213499]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View