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TCMDC-125846 (CID 972880) - Compound BioActivity Data
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BioActivity Outcomes:
Active(130)
 
 
Inactive(658)
 
 
Inconclusive(47)
 
 
Unspecified(23)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
 
7TM GPCR Srsx(21)
 
 
 
 
alkPPc(12)
 
 
Death TRAILR..(12)
 
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(552)
 
 
 
 
 
Confirmatory(277)
 
 
 
 
 
Literature(14)
 
 
 
BioActivity Types:
Potency(154)
 
 
 
 
 
IC50(62)
 
 
 
 
 
EC50(37)
 
 
 
 
 
AC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 767    Data Row: 858   Total Pages: 43   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14726352]
Potency 0.0224qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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2
[SID14726352]
Potency 0.13qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID14726352]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID14726352]
EC50 0.16Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response [AID1241, Type: confirmatory]transcription factor p65 isoform 1 [Homo sapiens] [gi:223468676]
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5
[SID14726352]
EC50 0.16Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response [AID1241, Type: confirmatory]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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6
[SID14726352]
SAMPLE2_EC50_uM 0.194Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJeLR Fibroblast [AID2610, Type: confirmatory]
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7
[SID14726352]
AC50_uM 0.29Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID14726352]
EC50_uM 0.428Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to Non-Viral Oncogenic DRD Fibroblast [AID2633, Type: confirmatory]
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9
[SID14726352]
AC50_uM 0.503Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 2144-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID720697, Type: confirmatory]
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10
[SID14726352]
EC50_Mean 0.64Dose response confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489024, Type: confirmatory]
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11
[SID14726352]
EC50_uM 0.661Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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12
[SID14726352]
EC50 0.705Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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13
[SID14726352]
AC50_uM 0.756ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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14
[SID14726352]
AC50_uM 0.756ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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15
[SID14726352]
Potency 0.7943qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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16
[SID14726352]
Potency 0.7943qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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17
[SID14726352]
EC50_uM 0.985Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT Fibroblast [AID2635, Type: confirmatory]
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18
[SID14726352]
Potency 1.0323qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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19
[SID14726352]
EC50 1.097Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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20
[SID14726352]
Potency 1.2995qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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