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10-hydroxycamptothecin (CID 97226) - Compound BioActivity Data
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BioActivity Outcomes:
Active(152)
 
 
Inactive(114)
 
 
Inconclusive(21)
 
 
Unspecified(72)
 
 
Top Targets:
PLDc mTdp1 2(6)
 
 
 
Peptidase C1A(4)
 
 
NR LBD TR(4)
 
 
Tubulin-bindi..(4)
 
 
Menin(4)
 
 
 
BioAssay Types:
Confirmatory(186)
 
 
 
 
Literature(123)
 
 
 
 
Screening(13)
 
 
BioActivity Types:
Potency(106)
 
 
 
 
IC50(52)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 314    Data Row: 359   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170545]
IC50 0.004Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay [AID690722, Type: Literature]
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2
[SID103170545]
IC50 0.0054Cytotoxicity against human HepG2 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326456, Type: Literature]
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3
[SID103170545]
IC50 0.0069Cytotoxicity against human H298 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326459, Type: Literature]
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4
[SID103170545]
IC50 0.0088Cytotoxicity against human HT29 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326458, Type: Literature]
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5
[SID103170545]
IC50 0.0091Cytotoxicity against human Colo 205 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326457, Type: Literature]
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6
[SID103170545]
IC50 0.012Inhibitory activity against P388 Leukemia cells [AID150662, Type: Literature]
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7
[SID103170545]
IC50 0.018Inhibitory activity in mice bearing L1210 leukemia [AID100463, Type: Literature]
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8
[SID50107786]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID26750003]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID103170545]
IC50 0.03Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay [AID481528, Type: Literature]
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11
[SID103170545]
IC50 0.0312Cytotoxicity against human HCT116 after 72 hrs by SRB assay [AID666763, Type: Literature]
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12
[SID103170545]
IC50 0.0336Cytotoxicity against human A549 after 72 hrs by SRB assay [AID666764, Type: Literature]
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13
[SID103170545]
GI50 0.036Mean GI50 against variety of human tumor cell lines [AID222948, Type: Literature]
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14
[SID103170545]
IC50 0.04Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID481527, Type: Literature]
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15
[SID50107786]
Potency 0.0517qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID26750003]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID103170545]
IC50 0.06Cytotoxicity against human MDA-MB-231 cells by MTT assay [AID746651, Type: Literature]
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18
[SID103170545]
IC50 0.07Cytotoxicity against human A549 cells by MTT assay [AID746652, Type: Literature]
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19
[SID103170545]
IC50 0.078Cytotoxicity against human PC3 cells expressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay [AID690587, Type: Literature]
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20
[SID103170545]
IC50 0.11Cytotoxicity against human U937 cells after 48 hrs by MTT assay [AID481529, Type: Literature]
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