10-hydroxycamptothecin (CID 97226) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(126)
 
 
Inactive(104)
 
 
Inconclusive(15)
 
 
Unspecified(41)
 
 
Top Targets:
Menin(4)
 
 
 
NR LBD ROR li..(4)
 
 
NR LBD TR(4)
 
 
Tubulin-bindi..(4)
 
 
Peptidase C1A(4)
 
 
BioAssay Types:
Confirmatory(169)
 
 
 
 
Literature(82)
 
 
 
Screening(13)
 
 
BioActivity Types:
Potency(91)
 
 
 
 
IC50(38)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 250    Data Row: 286   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170545]
IC50 0.0054Cytotoxicity against human HepG2 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326456, Type: Literature]
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2
[SID103170545]
IC50 0.0069Cytotoxicity against human H298 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326459, Type: Literature]
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3
[SID103170545]
IC50 0.0088Cytotoxicity against human HT29 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326458, Type: Literature]
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4
[SID103170545]
IC50 0.0091Cytotoxicity against human Colo 205 cells assessed as inhibition of [3H]thymidine after 48 hrs [AID326457, Type: Literature]
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5
[SID103170545]
IC50 0.012Inhibitory activity against P388 Leukemia cells [AID150662, Type: Literature]
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6
[SID103170545]
IC50 0.018Inhibitory activity in mice bearing L1210 leukemia [AID100463, Type: Literature]
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7
[SID50107786]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID50107786]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID50107786]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID26750003]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID26750003]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID26750003]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID103170545]
IC50 0.03Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay [AID481528, Type: Literature]
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14
[SID103170545]
IC50 0.0312Cytotoxicity against human HCT116 after 72 hrs by SRB assay [AID666763, Type: Literature]
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15
[SID103170545]
IC50 0.0336Cytotoxicity against human A549 after 72 hrs by SRB assay [AID666764, Type: Literature]
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16
[SID103170545]
GI50 0.036Mean GI50 against variety of human tumor cell lines [AID222948, Type: other]
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17
[SID103170545]
IC50 0.04Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID481527, Type: Literature]
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18
[SID50107786]
Potency 0.0517qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID50107786]
Potency 0.0517qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID50107786]
Potency 0.0517qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID26750003]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID26750003]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID26750003]
Potency 0.058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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24
[SID103170545]
IC50 0.11Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells [AID210946, Type: Literature]
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25
[SID103170545]
IC50 0.11Cytotoxicity against human U937 cells after 48 hrs by MTT assay [AID481529, Type: Literature]
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26
[SID103170545]
IC50 0.11Antitumor activity against human A549/ATCC cells by SRB method [AID426062, Type: Literature]
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27
[SID103170545]
IC50 0.14Growth inhibition of human SMMC7721 cells after 48 hrs by MTT assay [AID468115, Type: Literature]
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28
[SID103170545]
IC50 0.148Inhibitory concentration against human HCT116 colon cancer cell line [AID247623, Type: Literature]
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29
[SID103170545]
IC50 0.16Cytotoxicity against human K562 cells after 72 hrs by MTT assay [AID477404, Type: Literature]
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30
[SID103170545]
IC50 0.2Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay [AID431814, Type: Literature]
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31
[SID103170545]
IC50 0.21Antitumor activity against human HT-29 cells by SRB method [AID426063, Type: Literature]
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32
[SID103170545]
IC50 0.23Antitumor against human GLC82 cells assessed as cell survival after 48 hrs by MTT assay [AID611122, Type: Literature]
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33
[SID103170545]
IC50 0.28Cytotoxicity against human Bel-7402 cells after 72 hrs by sulforhodamine B assay [AID379166, Type: Literature]
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34
[SID103170545]
IC50 0.36Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay [AID477406, Type: Literature]
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35
[SID103170545]
IC50 0.37Cytotoxicity against human CNE2 cells after 48 hrs by MTT assay [AID436375, Type: Literature]
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36
[SID103170545]
IC50 0.4Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay [AID421696, Type: Literature]
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37
[SID103170545]
IC50 0.41Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay [AID379165, Type: Literature]
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38
[SID103170545]
IC50 0.496Antitumor activity against mouse C26 cells by WST-1 assay [AID591019, Type: Literature]
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39
[SID103170545]
IC50 0.6Cytotoxicity against human KB cells after 48 hrs by MTT assay [AID431812, Type: Literature]
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40
[SID103170545]
IC50 0.7Cytotoxicity against human A2780 cells after 48 hrs by MTT assay [AID431813, Type: Literature]
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41
[SID103170545]
IC50 0.829Antitumor activity against human KB cells by WST-1 assay [AID591017, Type: Literature]
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42
[SID103170545]
IC50 0.981Antitumor activity against human HepG2 cells by WST-1 assay [AID591018, Type: Literature]
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43
[SID103170545]
CC50 1Cytotoxicity against DNA topoisomerase I purified from calf thymus [AID56562, Type: Literature]
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44
[SID103170545]
IC50 1.04Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay [AID611121, Type: Literature]
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45
[SID103170545]
IC50 1.09Cytotoxicity against human GLC82 cells after 48 hrs by MTT assay [AID436376, Type: Literature]
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46
[SID103170545]
IC50 2.47Inhibitory concentration against human Bel-7402 liver cancer cell line [AID247637, Type: Literature]
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47
[SID103170545]
IC50 3.7Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay [AID481526, Type: Literature]
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48
[SID103170545]
IC50 4.1Cytotoxicity against human K562 cells after 72 hrs by MTT assay [AID421695, Type: Literature]
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49
[SID103170545]
IC50 6.49Cytotoxicity against human Hep G2 after 48 hrs by MTT assay [AID378061, Type: Literature]
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50
[SID26750003]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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