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8-aminoadenosine (CID 96851) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(5)
 
 
Unspecified(6)
 
 
Top Targets:
ADA(1)
 
 
BioAssay Types:
Literature(20)
 
 
 
 
BioActivity Types:
Kd(4)
 
 
IC50(4)
 
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103594953]
GI50 0.05Cytotoxicity against human HCT116 cells by SRB assay [AID393508, Type: Literature]
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2
[SID103594953]
GI50 0.05Antiproliferative activity against human HCT116 cells [AID600789, Type: Literature]
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3
[SID103594953]
Ki 4.46Inhibition of HSP70 by fluorescence polarization assay [AID600787, Type: Literature]
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4
[SID103594953]
Kd 6.8Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis [AID600785, Type: Literature]
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5
[SID103594953]
IC50 9.4Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay [AID393506, Type: Literature]
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6
[SID103594953]
Kd 11Binding affinity to HSP70 by Biocore direct binding assay [AID393507, Type: Literature]
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7
[SID103594953]
Kd 11Binding affinity to HSP70 by surface plasmon resonance analysis [AID600786, Type: Literature]
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8
[SID103594953]
Kd 14.14Binding affinity to Grp78 by isothermal titration calorimetric analysis [AID600788, Type: Literature]
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9
[SID103594953]
Ki 24.1Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand [AID33792, Type: Literature]
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10
[SID103594953]
Ki 89.5Inhibition of calf placental adenosine deaminase by Lineweaver-Burk plot analysis [AID554262, Type: Literature]Adenosine deaminase [gi:20141178]
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11
[SID103594953]
IC50 400Binding affinity to HSP90 by fluorescence polarization assay [AID393511, Type: Literature]
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12
[SID103594953]
Ionization state of the molecule at physiological pH was evaluated by potentiometry . [AID25809, Type: Literature]
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13
[SID103594953]
Binding affinity determined on Adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. [AID31247, Type: Literature]
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14
[SID103594953]
Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat Adenosine A3 receptor [AID33205, Type: Literature]
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15
[SID103594953]
Cytotoxicity against mouse J774A1 cells [AID584550, Type: Literature]
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16
[SID103594953]
Inhibition of HSP70 in human HCT116 cells assessed as reduction of He2 protein levels after 24 hrs by western blot [AID393509, Type: Literature]
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17
[SID103594953]
Inhibition of HSP70 in human HCT116 cells assessed as reduction of Raf1 protein levels after 24 hrs by western blot [AID393510, Type: Literature]
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18
[SID103594953]
IC50 Inhibition of inosine/L-alanine-induced Bacillus anthracis Sterne 34F2 spore germination pretreated for 15 mins before inosine/L-alanine challenge [AID584546, Type: Literature]
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19
[SID103594953]
IC50 Antibacterial activity against Bacillus anthracis Sterne 34F2 infected in mouse J774A.1 cells assessed as protection against bacteria-induced cytotoxicity using propidium iodide staining after 3 hrs measured every hours for up to 7 hrs [AID584547, Type: Literature]
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20
[SID103594953]
Activation of Bacillus anthracis Sterne 34F2 spore germination after 1 hr [AID584549, Type: Literature]
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