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Methysergide (CID 9681) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(67)
 
 
Inactive(249)
 
 
Inconclusive(57)
 
 
Unspecified(152)
 
 
Top Targets:
7TM GPCR Srx(29)
 
 
 
 
 
7TM GPCR Srsx(27)
 
 
 
 
p450(10)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Confirmatory(189)
 
 
 
 
Literature(149)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(20)
 
 
 
BioActivity Types:
Potency(205)
 
 
 
 
IC50(142)
 
 
 
 
Ki(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 446    Data Row: 525   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103292415]
IC50 0.000563DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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2
[SID103292415]
Ki 0.00158Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells [AID707294, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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3
[SID103292415]
Ki 0.0016Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand. [AID5581, Type: Literature]
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4
[SID103292415]
Ki 0.00192Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196754, Type: Literature]
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5
[SID103292415]
IC50 0.00209DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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6
[SID103292415]
Ki 0.0025Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells [AID378828, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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7
[SID103292415]
IC50 0.00501Tested for 5-hydroxytryptamine 2 receptor binding ability by displacement of [3H]spiperone from rat brain frontal cortex synaptosomes [AID5072, Type: Literature]
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8
[SID103292415]
Ki 0.0053Binding affinity which represents concentration giving half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor from rat tissue homogenate [AID5249, Type: Literature]
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9
[SID103292415]
Ki 0.0057Displacement of [3H]ketanserin from 5HT2A receptor in rabbit cerebral cortex membrane [AID402828, Type: Literature]
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10
[SID103292415]
Ki 0.00674Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196755, Type: Literature]
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11
[SID103292415]
Ki 0.0068Displacement of [3H]ketanserin from 5HT2 receptor [AID337898, Type: Literature]
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12
[SID103292415]
IC50 0.00741Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196752, Type: Literature]
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13
[SID103292415]
Ki 0.01Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells [AID378827, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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14
[SID103292415]
Ki 0.01259Binding affinity towards 5-hydroxytryptamine 7 receptor [AID6670, Type: Literature]
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15
[SID103292415]
IC50 0.013DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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16
[SID103292415]
IC50 0.01349Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196753, Type: Literature]
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17
[SID103292415]
Ki 0.0148Displacement of [3H]5HT from 5HT1 receptor [AID337897, Type: Literature]
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18
[SID103292415]
IC50 0.02Antagonist activity at serotonin receptor in guinea pig ileum assessed as inhibition of serotonin-induced contraction [AID398675, Type: Literature]
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19
[SID103292415]
IC50 0.03162Tested for 5-hydroxytryptamine 1 receptor binding ability by displacement of [3H]5-HT from rat brain synaptosomes [AID3701, Type: Literature]
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20
[SID103292415]
IC50 0.054DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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21
[SID103292415]
IC50 0.162DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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22
[SID103292415]
IC50 0.172DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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23
[SID103292415]
IC50 0.177DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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24
[SID103292415]
IC50 0.356HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells [AID685501, Type: other]
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25
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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26
[SID103292415]
IC50 0.943DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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27
[SID90340563]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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28
[SID103292415]
IC50 1.631DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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29
[SID103292415]
IC50 2.519DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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30
[SID26751590]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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31
[SID144204446]
AhR Potency (uM) 3.34915qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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32
[SID103292415]
IC50 3.559DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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33
[SID103292415]
IC50 4.763DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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34
[SID90340563]
Potency 6.3096qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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35
[SID90340563]
Potency 10.6213qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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36
[SID144204446]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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37
[SID144204446]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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38
[SID144204446]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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39
[SID90340563]
Potency 16.8336qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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40
[SID90340563]
Potency 18.8876Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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41
[SID90340563]
Potency 28.1838Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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42
[SID26751590]
Potency 39.8107qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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43
[SID135650596]
Agonists at Human 5-Hydroxytryptamine receptor 5-HT2B [AID624219, Type: Literature]5-hydroxytryptamine receptor 2B [Homo sapiens] [gi:222080049]
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44
[SID135650596]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2A [AID624223, Type: Literature]5-hydroxytryptamine receptor 2A isoform 2 [Homo sapiens] [gi:260099679]
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45
[SID135650596]
Antagonists at Rat 5-Hydroxytryptamine receptor 5-HT1F [AID624229, Type: Literature]5-hydroxytryptamine receptor 1F [Rattus norvegicus] [gi:281599319]
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46
[SID135650596]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2C [AID624209, Type: Literature]5-hydroxytryptamine receptor 2C isoform b precursor [Homo sapiens] [gi:377520139]
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47
[SID85787459]
SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]myc proto-oncogene protein [Homo sapiens] [gi:71774083]
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48
[SID135650596]
Antagonists at Mouse 5-Hydroxytryptamine receptor 5-HT7 [AID624183, Type: Literature]5-hydroxytryptamine receptor 7 [Mus musculus] [gi:113865998]
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49
[SID135650596]
Antagonists at Mouse 5-Hydroxytryptamine receptor 5-ht5a [AID624186, Type: Literature]5-hydroxytryptamine receptor 5A [Mus musculus] [gi:84370345]
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50
[SID135650596]
Antagonists at Rat 5-Hydroxytryptamine receptor 5-HT7 [AID624180, Type: Literature]5-hydroxytryptamine receptor 7 [Rattus norvegicus] [gi:12621102]
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