Methysergide (CID 9681) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(59)
 
 
Inactive(166)
 
 
Inconclusive(38)
 
 
Unspecified(152)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
 
 
7TM GPCR Srsx(14)
 
 
 
 
p450(8)
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
 
BioAssay Types:
Literature(139)
 
 
 
 
 
Confirmatory(109)
 
 
 
 
Screening(20)
 
 
 
BioActivity Types:
IC50(139)
 
 
 
 
Potency(108)
 
 
 
 
Ki(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 345    Data Row: 415   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103292415]
IC50 0.000563DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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2
[SID103292415]
IC50 0.000563DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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3
[SID103292415]
IC50 0.000563DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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4
[SID103292415]
Ki 0.0016Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand. [AID5581, Type: Literature]
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5
[SID103292415]
Ki 0.00192Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196754, Type: Literature]
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6
[SID103292415]
IC50 0.00209DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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7
[SID103292415]
IC50 0.00209DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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8
[SID103292415]
IC50 0.00209DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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9
[SID103292415]
Ki 0.0025Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells [AID378828, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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10
[SID103292415]
Ki 0.0025Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells [AID378828, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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11
[SID103292415]
Ki 0.0025Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells [AID378828, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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12
[SID103292415]
IC50 0.00501Tested for 5-hydroxytryptamine 2 receptor binding ability by displacement of [3H]spiperone from rat brain frontal cortex synaptosomes [AID5072, Type: Literature]
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13
[SID103292415]
Ki 0.0053Binding affinity which represents concentration giving half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor from rat tissue homogenate [AID5249, Type: Literature]
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14
[SID103292415]
Ki 0.0057Displacement of [3H]ketanserin from 5HT2A receptor in rabbit cerebral cortex membrane [AID402828, Type: Literature]
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15
[SID103292415]
Ki 0.00674Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196755, Type: Literature]
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16
[SID103292415]
Ki 0.0068Displacement of [3H]ketanserin from 5HT2 receptor [AID337898, Type: other]
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17
[SID103292415]
Ki 0.01Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells [AID378827, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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18
[SID103292415]
Ki 0.01Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells [AID378827, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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19
[SID103292415]
Ki 0.01Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells [AID378827, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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20
[SID103292415]
IC50 0.013DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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21
[SID103292415]
IC50 0.013DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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22
[SID103292415]
IC50 0.013DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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23
[SID103292415]
Ki 0.0148Displacement of [3H]5HT from 5HT1 receptor [AID337897, Type: other]
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24
[SID103292415]
IC50 0.02Antagonist activity at serotonin receptor in guinea pig ileum assessed as inhibition of serotonin-induced contraction [AID398675, Type: other]
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25
[SID103292415]
IC50 0.03162Tested for 5-hydroxytryptamine 1 receptor binding ability by displacement of [3H]5-HT from rat brain synaptosomes [AID3701, Type: Literature]
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26
[SID103292415]
IC50 0.054DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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27
[SID103292415]
IC50 0.162DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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28
[SID103292415]
IC50 0.162DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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29
[SID103292415]
IC50 0.162DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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30
[SID103292415]
IC50 0.172DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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31
[SID103292415]
IC50 0.172DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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32
[SID103292415]
IC50 0.172DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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33
[SID103292415]
IC50 0.172DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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34
[SID103292415]
IC50 0.177DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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35
[SID103292415]
IC50 0.177DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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36
[SID103292415]
IC50 0.356HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells [AID685501, Type: other]
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37
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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38
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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39
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
40
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
41
[SID103292415]
IC50 0.807DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
42
[SID103292415]
IC50 0.943DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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43
[SID103292415]
IC50 0.943DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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44
[SID103292415]
IC50 0.943DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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45
[SID103292415]
IC50 0.943DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
View
46
[SID90340563]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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47
[SID90340563]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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48
[SID90340563]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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49
[SID90340563]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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50
[SID103292415]
IC50 1.631DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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