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Methysergide (CID 9681) - Compound BioActivity Data
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BioActivity Outcomes:
Active(86)
 
 
Inactive(255)
 
 
Inconclusive(55)
 
 
Unspecified(170)
 
 
Top Targets:
7TM GPCR Srx(35)
 
 
 
 
 
7TM GPCR Srsx(30)
 
 
 
 
p450(10)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD PPAR(8)
 
 
 
BioAssay Types:
Confirmatory(307)
 
 
 
 
 
Literature(192)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(20)
 
 
 
BioActivity Types:
Potency(207)
 
 
 
 
IC50(142)
 
 
 
 
Ki(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 467    Data Row: 566   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103292415]
IC50 0.000563DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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2
[SID103292415]
Ki 0.00158Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells [AID707294, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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3
[SID103292415]
Ki 0.0016Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand. [AID5581, Type: Literature]
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4
[SID103292415]
Ki 0.00192Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196754, Type: Literature]
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5
[SID103292415]
IC50 0.00209DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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6
[SID103292415]
Ki 0.0025Displacement of [N-methyl-3H]LSD from human 5HT2C receptor expressed in HEK293 cells [AID378828, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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7
[SID103292415]
IC50 0.00501Tested for 5-hydroxytryptamine 2 receptor binding ability by displacement of [3H]spiperone from rat brain frontal cortex synaptosomes [AID5072, Type: Literature]
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8
[SID103292415]
Ki 0.0053Binding affinity which represents concentration giving half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor from rat tissue homogenate [AID5249, Type: Literature]
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9
[SID103292415]
Ki 0.0057Displacement of [3H]ketanserin from 5HT2A receptor in rabbit cerebral cortex membrane [AID402828, Type: Literature]
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10
[SID103292415]
Ki 0.00674Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196755, Type: Literature]
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11
[SID103292415]
Ki 0.0068Displacement of [3H]ketanserin from 5HT2 receptor [AID337898, Type: Literature]
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12
[SID103292415]
IC50 0.00741Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196752, Type: Literature]
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13
[SID103292415]
Ki 0.00759Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) [AID1063805, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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14
[SID103292415]
Ki 0.01Displacement of [N-methyl-3H]LSD from human 5HT2A receptor expressed in HEK293 cells [AID378827, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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15
[SID103292415]
Ki 0.01259Binding affinity towards 5-hydroxytryptamine 7 receptor [AID6670, Type: Literature]
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16
[SID103292415]
IC50 0.013DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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17
[SID103292415]
IC50 0.01349Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196753, Type: Literature]
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18
[SID103292415]
Ki 0.0148Displacement of [3H]5HT from 5HT1 receptor [AID337897, Type: Literature]
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19
[SID103292415]
IC50 0.02Antagonist activity at serotonin receptor in guinea pig ileum assessed as inhibition of serotonin-induced contraction [AID398675, Type: Literature]
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20
[SID103292415]
IC50 0.03162Tested for 5-hydroxytryptamine 1 receptor binding ability by displacement of [3H]5-HT from rat brain synaptosomes [AID3701, Type: Literature]
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