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Galantamine (CID 9651) - Compound BioActivity Data
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BioActivity Outcomes:
Active(116)
 
 
Inactive(198)
 
 
Inconclusive(16)
 
 
Unspecified(252)
 
 
Top Targets:
Esterase lipa..(96)
 
 
 
 
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(17)
 
 
 
p450(11)
 
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Literature(309)
 
 
 
 
 
Confirmatory(97)
 
 
 
 
Screening(17)
 
 
Summary(15)
 
 
 
BioActivity Types:
IC50(241)
 
 
 
 
 
Potency(105)
 
 
 
 
Ki(7)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 508    Data Row: 582   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189275]
MIC 3e-06Inhibition of AChE assessed as minimum drug level causing white zone of enzyme inhibition by TLC bioautography [AID482723, Type: Literature]
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2
[SID103189275]
Ki 0.06196Inhibition of human recombinant AChE using acetylthiocholine as substrate [AID694073, Type: Literature]Acetylcholinesterase [gi:113037]
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3
[SID103189275]
IC50 0.1Inhibitory activity against acetylcholinesterase in human RBC [AID31026, Type: other]
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4
[SID103189275]
Ki 0.19247Inhibition of human recombinant BChE using acetylthiocholine as substrate [AID694074, Type: Literature]Cholinesterase [gi:116353]
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5
[SID103189275]
IC50 0.3Inhibition of acetylcholinesterase (unknown origin) [AID724168, Type: Literature]Acetylcholinesterase [gi:113037]
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6
[SID103189275]
IC50 0.3Inhibition of human AChE by Ellman's method [AID656684, Type: Literature]Acetylcholinesterase [gi:113037]
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7
[SID103189275]
Ki 0.3Inhibition of AChE by Ellman's assay [AID501440, Type: Literature]
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8
[SID103189275]
IC50 0.35Inhibition of human AChE [AID407780, Type: Literature]Acetylcholinesterase [gi:113037]
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9
[SID103189275]
IC50 0.35Inhibition of AChE-induced amyloid beta aggregation [AID594820, Type: Literature]
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10
[SID103189275]
IC50 0.36Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition) [AID30666, Type: Literature]Acetylcholinesterase [gi:543754]
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11
[SID103189275]
IC50 0.36Compound was assessed for in vitro inhibition of Acetylcholinesterase isolated from Electrophorus electricus [AID30543, Type: Literature]Acetylcholinesterase [gi:14916521]
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12
[SID103189275]
IC50 0.36Inhibition of Electrophorus electricus AChE by Ellman's method [AID302143, Type: Literature]Acetylcholinesterase [gi:14916521]
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13
[SID103189275]
Ki 0.428Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burke plot analysis [AID499448, Type: Literature]Acetylcholinesterase [gi:14916521]
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14
[SID103189275]
IC50 0.5Inhibitory activity against AChE from electric eel [AID260079, Type: Literature]Acetylcholinesterase [gi:14916521]
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15
[SID103189275]
IC50 0.5Inhibition of acetylcholinesterase [AID362527, Type: Literature]
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16
[SID103189275]
IC50 0.5Inhibition of AchE [AID365698, Type: Literature]
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17
[SID103189275]
IC50 0.53Inhibition of AChE by Ellman's method [AID566361, Type: Literature]
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18
[SID103189275]
IC50 0.538In vitro inhibitory effect on rat Acetylcholinesterase [AID31964, Type: Literature]
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19
[SID103189275]
IC50 0.55Inhibition of AChE [AID294501, Type: Literature]
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20
[SID103189275]
IC50 0.55Inhibition of electric eel AChE [AID307545, Type: Literature]Acetylcholinesterase [gi:14916521]
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21
[SID103189275]
IC50 0.55Inhibition of electric eel AChE by Ellman's method [AID421514, Type: Literature]Acetylcholinesterase [gi:14916521]
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22
[SID103189275]
IC50 0.56Inhibition of electric eel AChE by Ellman's method [AID482856, Type: Literature]Acetylcholinesterase [gi:14916521]
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23
[SID103189275]
IC50 0.59Inhibition of Torpedo californica AchE activity by Ellman's assay [AID343772, Type: Literature]Acetylcholinesterase [gi:543754]
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24
[SID103189275]
IC50 0.59Inhibition of AChE activity [AID263610, Type: Literature]Acetylcholinesterase [gi:113037]
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25
[SID103189275]
IC50 0.6Inhibition of AChE [AID276345, Type: Literature]Acetylcholinesterase [gi:113037]
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26
[SID103189275]
IC50 0.6Inhibition of AChE in human erythrocytes by Ellman's method [AID482855, Type: Literature]Acetylcholinesterase [gi:113037]
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27
[SID103189275]
IC50 0.6Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's method [AID656680, Type: Literature]Acetylcholinesterase [gi:14916521]
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28
[SID103189275]
IC50 0.623Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay [AID666573, Type: Literature]Acetylcholinesterase [gi:14916521]
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29
[SID103189275]
IC50 0.623Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method [AID635414, Type: Literature]Acetylcholinesterase [gi:14916521]
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30
[SID103189275]
IC50 0.623Inhibition of electric eel AChE by modified Ellman method [AID456905, Type: Literature]Acetylcholinesterase [gi:14916521]
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31
[SID103189275]
IC50 0.623Inhibition of electric eel AChE by Ellman's assay [AID486994, Type: Literature]Acetylcholinesterase [gi:14916521]
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32
[SID103189275]
IC50 0.623Inhibition of electric eel Acetylcholinesterase [AID593738, Type: Literature]Acetylcholinesterase [gi:14916521]
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33
[SID103189275]
IC50 0.63Acetylcholinesterase inhibitory activity in rat striatal homogenates [AID32105, Type: Literature]
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34
[SID103189275]
IC50 0.63533Inhibition of electric eel AChE by modified Ellman's method [AID480448, Type: Literature]Acetylcholinesterase [gi:14916521]
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35
[SID103189275]
IC50 0.64Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay [AID479753, Type: Literature]Acetylcholinesterase [gi:14916521]
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36
[SID103189275]
IC50 0.64Inhibition of electric eel AChE by Ellman's method [AID569581, Type: Literature]Acetylcholinesterase [gi:14916521]
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37
[SID103189275]
IC50 0.64Inhibition of electric eel AChE by colorimetric Ellman's assay [AID603787, Type: Literature]Acetylcholinesterase [gi:14916521]
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38
[SID103189275]
IC50 0.64Inhibition of electric eel AChE [AID271048, Type: Literature]Acetylcholinesterase [gi:14916521]
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39
[SID103189275]
IC50 0.64Inhibition of electric eel AChE type 6S by Ellman's assay [AID383197, Type: Literature]Acetylcholinesterase [gi:14916521]
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40
[SID103189275]
IC50 0.652Inhibition of Torpedo californica AChE [AID404434, Type: Literature]Acetylcholinesterase [gi:543754]
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41
[SID103189275]
IC50 0.747Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay [AID707048, Type: Literature]
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42
[SID103189275]
IC50 0.75Inhibition against acetylcholinesterase (AChE) [AID31968, Type: Literature]
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43
[SID103189275]
IC50 0.8Ex vivo inhibition of human erythrocyte Acetylcholinesterase. [AID31163, Type: Literature]
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44
[SID103189275]
IC50 0.8Inhibition of human erythrocytes AChE [AID600978, Type: Literature]Acetylcholinesterase [gi:113037]
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45
[SID103189275]
IC50 0.8Inhibition of human plasma AChE [AID600979, Type: Literature]Acetylcholinesterase [gi:113037]
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46
[SID103189275]
IC50 0.8Inhibitory concentration against human erythrocyte Acetylcholinesterase [AID241692, Type: Literature]Acetylcholinesterase [gi:113037]
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47
[SID103189275]
IC50 0.8Anticholinesterase activity against human erythrocyte AChE [AID262754, Type: Literature]Acetylcholinesterase [gi:113037]
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48
[SID103189275]
IC50 0.92Inhibition of rat brain acetylcholinesterase by colorimetric method [AID333566, Type: Literature]Acetylcholinesterase [gi:584716]
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49
[SID103189275]
IC50 0.98Inhibition of AChE by microplate assay [AID381366, Type: Literature]
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50
[SID103189275]
IC50 1Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate addition [AID676724, Type: Literature]Acetylcholinesterase [gi:113037]
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