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BioActivity Data for Compound Galantamine (CID 9651)

BioActivity Outcomes:
Active(163)
 
 
Inactive(206)
 
 
Inconclusive(17)
 
 
Unspecified(451)
 
 
Top Targets:
Esterase lipa..(144)
 
 
 
 
7tm 4(33)
 
 
 
p450(11)
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(8)
 
 
 
BioAssay Types:
Literature(384)
 
 
 
 
 
Confirmatory(226)
 
 
 
 
 
Screening(17)
 
 
Summary(15)
 
 
 
BioAssay Categories:
In vitro(138)
 
 
 
In vivo(179)
 
 
 
Biochemical(377)
 
 
 
 
 
Toxicity(197)
 
 
 
 
ADME(26)
 
 
 
Cell-based(102)
 
 
 
 
BioActivity Types:
IC50(285)
 
 
 
 
 
Potency(106)
 
 
 
 
Ki(7)
 
 
 
 
AC50(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 760    Data Row: 837   Total Pages: 42   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189275]
Ki 0.06196Inhibition of human recombinant AChE using acetylthiocholine as substrate [AID694073, Type: Literature]Acetylcholinesterase [gi:113037]
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2
[SID103189275]
IC50 0.1Inhibitory activity against acetylcholinesterase in human RBC [AID31026, Type: confirmatory]
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3
[SID103189275]
IC50 0.17Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine chloride as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis [AID1085841, Type: confirmatory]Cholinesterase [gi:116353]
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4
[SID103189275]
Ki 0.19247Inhibition of human recombinant BChE using acetylthiocholine as substrate [AID694074, Type: Literature]Cholinesterase [gi:116353]
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5
[SID103189275]
IC50 0.3Inhibition of human AChE by Ellman's method [AID656684, Type: Literature]Acetylcholinesterase [gi:113037]
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6
[SID103189275]
IC50 0.3Inhibition of acetylcholinesterase (unknown origin) [AID724168, Type: Literature]Acetylcholinesterase [gi:113037]
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7
[SID103189275]
Ki 0.3Inhibition of AChE by Ellman's assay [AID501440, Type: Literature]
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8
[SID103189275]
IC50 0.35Inhibition of human AChE [AID407780, Type: Literature]Acetylcholinesterase [gi:113037]
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9
[SID103189275]
IC50 0.35Inhibition of AChE-induced amyloid beta aggregation [AID594820, Type: Literature]
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10
[SID103189275]
IC50 0.36Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition) [AID30666, Type: Literature]Acetylcholinesterase [gi:543754]
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11
[SID46393027]
IC50 0.36Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Acetylcholinesterase (E.C.3.1.1.7) [gi:6730559]
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12
[SID46393027]
IC50 0.36Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Acetylcholinesterase (E.C.3.1.1.7) [gi:6730559]
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13
[SID103189275]
IC50 0.36Inhibition of Electrophorus electricus AChE by Ellman's method [AID302143, Type: Literature]Acetylcholinesterase [gi:14916521]
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14
[SID103189275]
IC50 0.36Compound was assessed for in vitro inhibition of Acetylcholinesterase isolated from Electrophorus electricus [AID30543, Type: Literature]Acetylcholinesterase [gi:14916521]
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15
[SID103189275]
Ki 0.428Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burke plot analysis [AID499448, Type: Literature]Acetylcholinesterase [gi:14916521]
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16
[SID103189275]
IC50 0.5Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) using acetylthiocholine iodide as substrate preincubated for 15 min [AID1085535, Type: confirmatory]Acetylcholinesterase [gi:14916521]
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17
[SID103189275]
IC50 0.5Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis [AID1085842, Type: confirmatory]Acetylcholinesterase [gi:113037]
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18
[SID103189275]
IC50 0.5Inhibition of acetylcholinesterase [AID362527, Type: Literature]
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19
[SID103189275]
IC50 0.5Inhibition of AchE [AID365698, Type: Literature]
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20
[SID103189275]
IC50 0.53Inhibition of AChE by Ellman's method [AID566361, Type: Literature]
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