2-methyl-1,2,3,4-tetrahydroquinoline (CID 96289) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(9)
 
 
Unspecified(7)
 
 
Top Targets:
23DHB-AMP lg(1)
 
 
Chorismate bi..(1)
 
 
DUF3346(1)
 
 
DnaB C(1)
 
 
Ggt(1)
 
 
BioAssay Types:
Literature(9)
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103724293]
IC50 33.96Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells [AID456262, Type: Literature]
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2
[SID103724293]
IC50 87.25Antitrypanosomal activity against Trypanosoma brucei rhodesiense infected in rat L6 cells [AID456259, Type: Literature]
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3
[SID103724293]
IC50 188.73Antitrypanosomal activity against Trypanosoma cruzi infected in rat L6 cells [AID456260, Type: Literature]
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4
[SID103724293]
IC50 248.61Cytotoxicity against rat L6 cells [AID456263, Type: Literature]
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5
[SID103724293]
IC50 611.33Antileishmanial activity against Leishmania donovani infected in rat L6 cells [AID456261, Type: Literature]
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6
[SID103724293]
 Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma cruzi infected in rat L6 cells [AID456264, Type: Literature]
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7
[SID103724293]
 Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells [AID456265, Type: Literature]
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8
[SID92165440]
 A screen for compounds that inhibit nucleocapsid/RNA interactions in Rift Valley Fever Virus [AID651828, Type: other]Nucleoprotein [gi:127925]
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9
[SID92165440]
 A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
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10
[SID92165440]
 A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI [AID493033, Type: other]Isochorismate synthase/isochorismate-pyruvate lyase mbtI [gi:81706979]
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11
[SID92165440]
 A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis [AID540299, Type: Literature]naphthoate synthase [Mycobacterium tuberculosis H37Rv] [gi:15607688]
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12
[SID92165440]
 A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
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13
[SID92165440]
 A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis [AID492967, Type: other]gamma-glutamyltranspeptidase [Bacillus anthracis str. 'Ames Ancestor'] [gi:47566732]
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14
[SID92165440]
 A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme BasE [AID485350, Type: screening]enterobactin synthase subunit E [Acinetobacter baumannii ATCC 17978] [gi:126642418]
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15
[SID92165440]
 A screen for compounds that inhibit the activity of Staphylococcus aureus DNA helicase [AID485395, Type: other]replicative DNA helicase [Staphylococcus aureus subsp. aureus JH1] [gi:150392496]
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16
[SID92165440]
 A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein [AID602314, Type: other]MarR family regulatory protein [Staphylococcus aureus subsp. aureus str. Newman] [gi:151220867]
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