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SMR000147643 (CID 9620303) - Compound BioActivity Data
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BioActivity Outcomes:
Active(41)
 
 
Inactive(708)
 
 
Inconclusive(20)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(25)
 
 
7TM GPCR Srsx(20)
 
 
 
Bcl-2 like(15)
 
 
 
alkPPc(12)
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(530)
 
 
 
 
 
Confirmatory(224)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(48)
 
 
 
 
EC50(14)
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 701    Data Row: 772   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14740808]
Potency 6.3096qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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2
[SID14740808]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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3
[SID14740808]
Potency 11.2202qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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4
[SID14740808]
Potency 11.2202qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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5
[SID14740808]
Potency 12.5893qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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6
[SID14740808]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID14740808]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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8
[SID14740808]
Potency 20.5962Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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9
[SID14740808]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID14740808]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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11
[SID14740808]
EC50_uM 27.96Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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12
[SID14740808]
EC50_uM 27.96Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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13
[SID14740808]
AC50_uM 40.3Luminescence Cell-Based Counterscreen to Identify Inhibitors of A1 Apoptosis (HMC 1-8 low) [AID449755, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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14
[SID14740808]
AC50_uM 40.71Luminescence Cell-Based Counterscreen to Identify Inhibitors of A1 Apoptosis (non-primed) [AID449761, Type: confirmatory]
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15
[SID14740808]
AC50_uM 45Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Bcl-2-like protein 11 [gi:18202042]
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16
[SID14740808]
AC50_uM 45Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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17
[SID14740808]
AC50_uM 46.63Luminescence Cell-Based Counterscreen to Identify Inhibitors of A1 Apoptosis (Bax-Bak knockout) [AID449754, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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18
[SID14740808]
IC50 79.98AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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19
[SID14740808]
IC50 79.98AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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20
[SID14740808]
IC50 79.98AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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21
[SID56422678]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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22
[SID14740808]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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23
[SID14740808]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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24
[SID14740808]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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25
[SID14740808]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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26
[SID14740808]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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27
[SID14740808]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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28
[SID14740808]
Single concentration confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID485299, Type: screening]
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29
[SID14740808]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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30
[SID14740808]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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31
[SID14740808]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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32
[SID14740808]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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33
[SID14740808]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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34
[SID14740808]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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35
[SID14740808]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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36
[SID14740808]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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37
[SID56422678]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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38
[SID14740808]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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39
[SID56422678]
Luminescence-based cell-based high throughput confirmation assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602192, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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40
[SID14740808]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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41
[SID14740808]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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42
[SID14740808]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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43
[SID14740808]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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44
[SID14740808]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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45
[SID14740808]
EC50_Mean 80Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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46
[SID14740808]
EC50_Mean 80Dose response confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489032, Type: confirmatory]
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47
[SID14740808]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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48
[SID14740808]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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49
[SID14740808]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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50
[SID14740808]
Factor XIa 1536 HTS [AID798, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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