SMR000218007 (CID 9620030) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(580)
 
 
Inconclusive(13)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
7TM GPCR Srsx(11)
 
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
 
BioAssay Types:
Screening(419)
 
 
 
 
 
Confirmatory(173)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(33)
 
 
EC50(7)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 607    Data Row: 607   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17513472]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID17513472]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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3
[SID17513472]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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4
[SID17513472]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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5
[SID17513472]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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6
[SID17513472]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID17513472]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID17513472]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID17513472]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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10
[SID17513472]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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11
[SID17513472]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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12
[SID17513472]
 Counterscreen for antagonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective antagonists [AID651780, Type: screening]GNA15 gene product [Homo sapiens] [gi:156104883]
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13
[SID17513472]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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14
[SID17513472]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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15
[SID17513472]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID651785, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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16
[SID17513472]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID651785, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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17
[SID17513472]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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18
[SID17513472]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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19
[SID17513472]
 Single concentration confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2764, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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20
[SID17513472]
 Single concentration confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2764, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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21
[SID17513472]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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22
[SID17513472]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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23
[SID17513472]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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24
[SID17513472]
 Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]DRD2 gene product [Homo sapiens] [gi:4503385]
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25
[SID17513472]
 Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]DRD2 gene product [Homo sapiens] [gi:4503385]
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26
[SID17513472]
 Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]DRD2 gene product [Homo sapiens] [gi:4503385]
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27
[SID17513472]
 Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]DRD2 gene product [Homo sapiens] [gi:4503385]
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28
[SID17513472]
 Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]DRD2 gene product [Homo sapiens] [gi:4503385]
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29
[SID17513472]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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30
[SID17513472]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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31
[SID17513472]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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32
[SID17513472]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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33
[SID17513472]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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34
[SID17513472]
Potency 1.0418Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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35
[SID17513472]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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36
[SID17513472]
 Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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37
[SID17513472]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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38
[SID17513472]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2 [Saccharomyces cerevisiae] [gi:171229]
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39
[SID17513472]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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40
[SID17513472]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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41
[SID17513472]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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42
[SID17513472]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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43
[SID17513472]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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44
[SID17513472]
 HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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45
[SID17513472]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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46
[SID17513472]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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47
[SID17513472]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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48
[SID17513472]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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49
[SID17513472]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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50
[SID17513472]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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